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| TissGeneSummary for CDH24 |
 Gene summary |
| Basic gene information | Gene symbol | CDH24 |
| Gene name | cadherin 24, type 2 | |
| Synonyms | CDH11L | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022478.3, NM_144985.3, | |
| Description | cadherin-24 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000139880 | ||
| HPRD : 13019 | ||
| Vega : OTTHUMG00000028715 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDH24 | |
| BioGPS: 64403 | ||
| Pathway | NCI Pathway Interaction Database: CDH24 | |
| KEGG: CDH24 | ||
| REACTOME: CDH24 | ||
| Pathway Commons: CDH24 | ||
| Context | iHOP: CDH24 | |
| ligand binding site mutation search in PubMed: CDH24 | ||
| UCL Cancer Institute: CDH24 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCUCEC,UCS | |
| Reference showing the relevant tissue of CDH24 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016337 | single organismal cell-cell adhesion | 12734196 | GO:0016337 | single organismal cell-cell adhesion | 12734196 |
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| TissGeneExp for CDH24 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.331682312 | -1.398256904 | 1.729939216 | 7.18E-21 | 9.51E-20 |
| THCA | -0.174324268 | -1.41709037 | 1.242766102 | 7.39E-24 | 7.11E-22 |
| LUAD | -0.352267079 | -1.619077424 | 1.266810345 | 6.32E-10 | 3.43E-09 |
| LIHC | -2.263533217 | -4.130313217 | 1.86678 | 4.52E-15 | 1.34E-13 |
| HNSC | 0.057819248 | -1.363576101 | 1.421395349 | 2.73E-13 | 1.20E-11 |
| ESCA | -0.006223036 | -1.334686672 | 1.328463636 | 0.00173 | 0.02114022 |
| BLCA | 0.275932467 | -1.243978059 | 1.519910526 | 1.14E-05 | 0.000216697 |
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| TissGene-miRNA for CDH24 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CDH24 |
| TissGeneSNV for CDH24 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G315S | HNSC | 1 |
| p.L344F | STAD | 1 |
| p.K139X | KIRP | 1 |
| p.V53I | LIHC | 1 |
| p.L152F | HNSC | 1 |
| p.F51L | THYM | 1 |
| p.R439H | LUAD | 1 |
| p.P286L | HNSC | 1 |
| p.Q50X | COAD | 1 |
| p.H175Q | ESCA | 1 |
| p.N100D | COAD | 1 |
| p.E676G | PRAD | 1 |
| p.V247A | COAD | 1 |
| p.N563D | LUSC | 1 |
| p.R74W | TGCT | 1 |
| p.E270Q | BRCA | 1 |
| p.G621D | LUAD | 1 |
| p.D568N | SKCM | 1 |
| p.L637F | SKCM | 1 |
| p.P717S | LUAD | 1 |
| p.S457I | LUAD | 1 |
| p.G166R | HNSC | 1 |
| p.E440K | BLCA | 1 |
| p.R679Q | HNSC | 1 |
| p.A434E | BRCA | 1 |
| p.G166_splice | GBM | 1 |
| p.D699Y | LUAD | 1 |
| p.R20H | SARC | 1 |
| p.S397F | SKCM | 1 |
| p.P711L | SKCM | 1 |
| p.T647I | SKCM | 1 |
| p.A709V | LUAD | 1 |
| p.I138T | UCEC | 1 |
| p.E629D | STAD | 1 |
| p.P717L | SKCM | 1 |
| p.G547R | BRCA | 1 |
| p.D544H | HNSC | 1 |
| p.E471K | BLCA | 1 |
| p.A398T | KICH | 1 |
| p.G690S | CESC | 1 |
| p.R323C | STAD | 1 |
| p.G241S | LUAD | 1 |
| p.S403F | SKCM | 1 |
| p.G708R | SKCM | 1 |
| p.G455C | ACC | 1 |
| p.I408V | KIRC | 1 |
| p.T433K | LUAD | 1 |
| p.V501M | LUSC | 1 |
| p.P711S | SKCM | 1 |
| p.D202N | LGG | 1 |
| p.Y590* | LAML | 1 |
| p.K139* | KIRP | 1 |
| p.I700M | LGG | 1 |
| p.P515L | SKCM | 1 |
| p.A630T | STAD | 1 |
| p.R664Q | STAD | 1 |
| p.E461K | LUSC | 1 |
| p.G85W | LUAD | 1 |
| p.R282Q | STAD | 1 |
| p.F51L | UCEC | 1 |
| p.E680K | SKCM | 1 |
| p.R209H | UCEC | 1 |
| p.S267F | SKCM | 1 |
| p.F136L | READ | 1 |
| p.A718T | STAD | 1 |
| p.R74W | PRAD | 1 |
| p.I138M | HNSC | 1 |
| p.R616C | STAD | 1 |
| p.F223L | UCEC | 1 |
| p.S126F | BLCA | 1 |
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| TissGeneCNV for CDH24 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDH24 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CDH24 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (tumor) | CDH24, CTNNB1, CTNND1, PPP1R16A, CTNNA1 (normal) |
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| TissGeneProg for CDH24 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CDH24 |
| TissGeneDrug for CDH24 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDH24 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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