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| TissGeneSummary for SULT1C2 |
 Gene summary |
| Basic gene information | Gene symbol | SULT1C2 |
| Gene name | sulfotransferase family, cytosolic, 1C, member 2 | |
| Synonyms | ST1C1|ST1C2|SULT1C1|humSULTC2 | |
| Cytomap | UCSC genome browser: 2q12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001056.3, NM_176825.2, | |
| Description | SULT1C#1sulfotransferase 1C1sulfotransferase 1C2sulfotransferase family, cytosolic, 1C, member 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602385 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198203 | ||
| HPRD : 03858 | ||
| Vega : OTTHUMG00000153215 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SULT1C2 | |
| BioGPS: 6819 | ||
| Pathway | NCI Pathway Interaction Database: SULT1C2 | |
| KEGG: SULT1C2 | ||
| REACTOME: SULT1C2 | ||
| Pathway Commons: SULT1C2 | ||
| Context | iHOP: SULT1C2 | |
| ligand binding site mutation search in PubMed: SULT1C2 | ||
| UCL Cancer Institute: SULT1C2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSTAD | |
| Reference showing the relevant tissue of SULT1C2 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0051923 | sulfation | 20056724 | GO:0051923 | sulfation | 20056724 |
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| TissGeneExp for SULT1C2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 3.817909882 | 5.327804327 | -1.509894444 | 1.89E-14 | 9.15E-14 |
| LUSC | -0.754652944 | 1.357641173 | -2.112294118 | 1.21E-10 | 4.51E-10 |
| COAD | 1.063049092 | -0.453054754 | 1.516103846 | 0.00322 | 0.00811855 |
| KICH | 6.414112938 | 5.267308938 | 1.146804 | 0.00394 | 0.007610657 |
| LIHC | 0.593976938 | -1.153911062 | 1.747888 | 0.00159 | 0.004149694 |
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| TissGene-miRNA for SULT1C2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SULT1C2 |
| TissGeneSNV for SULT1C2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E63Q | BLCA | 3 |
| p.E36K | LUSC | 1 |
| p.R156K | SKCM | 1 |
| p.R241C | COAD | 1 |
| p.R131Q | STAD | 1 |
| p.M194I | ESCA | 1 |
| p.D261G | UCEC | 1 |
| p.W120X | SKCM | 1 |
| p.E279K | HNSC | 1 |
| p.R252C | SARC | 1 |
| p.R217L | KIRP | 1 |
| p.R131Q | SKCM | 1 |
| p.E290K | HNSC | 1 |
| p.D60G | UCEC | 1 |
| p.R206W | COAD | 1 |
| p.E57K | SKCM | 1 |
| p.I175T | UCEC | 1 |
| p.H198Y | LGG | 1 |
| p.D6E | LUAD | 1 |
| p.R252C | SKCM | 1 |
| p.S265F | SKCM | 1 |
| p.V180G | LGG | 1 |
| p.S92T | LIHC | 1 |
| p.P153T | LUSC | 1 |
| p.D233H | BLCA | 1 |
| p.I164T | UCEC | 1 |
| p.E95K | HNSC | 1 |
| p.E169G | OV | 1 |
| p.V16E | HNSC | 1 |
| p.T108S | DLBC | 1 |
| p.K214N | LUSC | 1 |
| p.V236I | LUAD | 1 |
| p.E95K | SKCM | 1 |
| p.R142Q | SKCM | 1 |
| p.N28H | SKCM | 1 |
| p.P91H | COAD | 1 |
| p.D186N | BLCA | 1 |
| p.A144S | ESCA | 1 |
| p.G8E | SKCM | 1 |
| p.E63X | ESCA | 1 |
| p.R206L | KIRP | 1 |
| p.P101S | STAD | 1 |
| p.P128L | LAML | 1 |
| p.D261V | LUAD | 1 |
| p.R142Q | STAD | 1 |
| p.S129Y | UCEC | 1 |
| p.W131* | SKCM | 1 |
| p.K107N | READ | 1 |
| p.S102F | SKCM | 1 |
| p.G166E | LUSC | 1 |
| p.K232N | READ | 1 |
| p.P81L | SKCM | 1 |
| p.V168L | LGG | 1 |
| p.E215D | SKCM | 1 |
| p.P81S | SKCM | 1 |
| p.D196N | BRCA | 1 |
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| TissGeneCNV for SULT1C2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SULT1C2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SULT1C2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| COAD (tumor) | COAD (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| KICH (tumor) | KICH (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| STAD (tumor) | STAD (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| THCA (tumor) | THCA (normal) |
| SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (tumor) | SULT1C2, TINF2, HNF4A, S100A9, POT1, ACD, HLTF, RASGRP3 (normal) |
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| TissGeneProg for SULT1C2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SULT1C2 |
| TissGeneDrug for SULT1C2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SULT1C2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002793 | Anaplasia | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | GAD |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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