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| TissGeneSummary for SERPINA7 |
 Gene summary |
| Basic gene information | Gene symbol | SERPINA7 |
| Gene name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | |
| Synonyms | TBG | |
| Cytomap | UCSC genome browser: Xq22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000354.5, | |
| Description | T4-binding globulinserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7serpin A7thyroxin-binding globulinthyroxine-binding globulin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 314200 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123561 | ||
| HPRD : 02438 | ||
| Vega : OTTHUMG00000022144 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SERPINA7 | |
| BioGPS: 6906 | ||
| Pathway | NCI Pathway Interaction Database: SERPINA7 | |
| KEGG: SERPINA7 | ||
| REACTOME: SERPINA7 | ||
| Pathway Commons: SERPINA7 | ||
| Context | iHOP: SERPINA7 | |
| ligand binding site mutation search in PubMed: SERPINA7 | ||
| UCL Cancer Institute: SERPINA7 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SERPINA7 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SERPINA7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 8.165141465 | 10.80435947 | -2.639218 | 1.17E-05 | 4.88E-05 |
| KICH | -2.091998535 | -0.708678535 | -1.38332 | 7.51E-06 | 2.43E-05 |
| COAD | -0.079672842 | -1.277392073 | 1.197719231 | 0.0109 | 0.02355217 |
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| TissGene-miRNA for SERPINA7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SERPINA7 |
| TissGeneSNV for SERPINA7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G131E | SKCM | 3 |
| p.S81F | SKCM | 3 |
| p.L153F | SKCM | 2 |
| p.L14R | STAD | 2 |
| p.W292X | SKCM | 2 |
| p.W292* | SKCM | 2 |
| p.L289Q | LUSC | 1 |
| p.R401K | SKCM | 1 |
| p.K170N | UCEC | 1 |
| p.P70L | SKCM | 1 |
| p.E125K | SKCM | 1 |
| p.V71L | LUAD | 1 |
| p.T339R | LUAD | 1 |
| p.L372R | COAD | 1 |
| p.F51L | LUSC | 1 |
| p.V106I | GBM | 1 |
| p.I92T | KIRP | 1 |
| p.Q297E | LUAD | 1 |
| p.F159L | ESCA | 1 |
| p.H31R | STAD | 1 |
| p.D388E | ACC | 1 |
| p.V158D | LUSC | 1 |
| p.A47S | UCEC | 1 |
| p.V185D | SKCM | 1 |
| p.P194T | LUAD | 1 |
| p.D102Y | UCEC | 1 |
| p.Q190H | HNSC | 1 |
| p.R401M | HNSC | 1 |
| p.L188R | LGG | 1 |
| p.L344M | LUAD | 1 |
| p.M241I | HNSC | 1 |
| p.T379I | SKCM | 1 |
| p.G317E | SKCM | 1 |
| p.G407W | CESC | 1 |
| p.V158A | LGG | 1 |
| p.S223Y | UCEC | 1 |
| p.V106L | LUSC | 1 |
| p.T230I | UCEC | 1 |
| p.Q234X | LIHC | 1 |
| p.S222N | SARC | 1 |
| p.E274V | SKCM | 1 |
| p.Q190E | BLCA | 1 |
| p.L321W | SKCM | 1 |
| p.P213L | ACC | 1 |
| p.E155G | READ | 1 |
| p.P213S | SKCM | 1 |
| p.S69F | SKCM | 1 |
| p.S262N | PAAD | 1 |
| p.Q326* | BRCA | 1 |
| p.D149H | LUAD | 1 |
| p.D334N | LUAD | 1 |
| p.A312D | COAD | 1 |
| p.V370F | SKCM | 1 |
| p.Q190* | SKCM | 1 |
| p.L346H | BRCA | 1 |
| p.E251K | SKCM | 1 |
| p.R294H | CESC | 1 |
| p.S160C | SKCM | 1 |
| p.A21S | LUSC | 1 |
| p.P70H | LUAD | 1 |
| p.D149N | HNSC | 1 |
| p.P236L | STAD | 1 |
| p.S373L | UCEC | 1 |
| p.K138N | UCEC | 1 |
| p.G183W | PAAD | 1 |
| p.G324D | UCEC | 1 |
| p.L153H | LUAD | 1 |
| p.P383T | LUAD | 1 |
| p.A318G | LUAD | 1 |
| p.P213S | COAD | 1 |
| p.E414G | SKCM | 1 |
| p.P383S | PAAD | 1 |
| p.H139N | LUAD | 1 |
| p.D149N | SKCM | 1 |
| p.R294C | ESCA | 1 |
| p.L80F | SKCM | 1 |
| p.P272S | SKCM | 1 |
| p.H31Q | LUAD | 1 |
| p.S347F | SKCM | 1 |
| p.K263N | UCEC | 1 |
| p.D102N | SKCM | 1 |
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| TissGeneCNV for SERPINA7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SERPINA7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SERPINA7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| COAD (tumor) | COAD (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| KICH (tumor) | KICH (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| STAD (tumor) | STAD (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| THCA (tumor) | THCA (normal) |
| SERPINA7, SLC16A2 (tumor) | SERPINA7, SLC16A2 (normal) |
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| TissGeneProg for SERPINA7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SERPINA7 |
| TissGeneDrug for SERPINA7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SERPINA7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C3711378 | Inherited Thyroxine-Binding Globulin Deficiency | 8 | BeFree |
| umls:C0342185 | Hyperthyroxinemia, Familial Dysalbuminemic | 6 | BeFree |
| umls:C0020550 | Hyperthyroidism | 4 | BeFree,RGD |
| umls:C1839141 | Thyroxine-Binding Globulin Deficiency | 3 | BeFree |
| umls:C0020551 | Hyperthyroxinemia | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0040156 | Thyrotoxicosis | 2 | BeFree |
| umls:C0206624 | Hepatoblastoma | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0013336 | Dwarfism | 1 | BeFree |
| umls:C0015190 | Euthyroid Sick Syndromes | 1 | BeFree |
| umls:C0018023 | Nodular Goiter | 1 | BeFree |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0020676 | Hypothyroidism | 1 | BeFree,RGD |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0086438 | Hypogammaglobulinemia | 1 | BeFree |
| umls:C0152025 | Polyneuropathy | 1 | BeFree |
| umls:C0520463 | Chronic active hepatitis | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1318500 | Non-toxic nodular goiter | 1 | BeFree |
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