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| TissGeneSummary for TDO2 |
 Gene summary |
| Basic gene information | Gene symbol | TDO2 |
| Gene name | tryptophan 2,3-dioxygenase | |
| Synonyms | TDO|TO|TPH2|TRPO | |
| Cytomap | UCSC genome browser: 4q31-q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005651.3, | |
| Description | TDOTOTRPOtryptamin 2,3-dioxygenasetryptophan oxygenasetryptophan pyrrolasetryptophanase | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 191070 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000151790 | ||
| HPRD : 01847 | ||
| Vega : OTTHUMG00000161838 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TDO2 | |
| BioGPS: 6999 | ||
| Pathway | NCI Pathway Interaction Database: TDO2 | |
| KEGG: TDO2 | ||
| REACTOME: TDO2 | ||
| Pathway Commons: TDO2 | ||
| Context | iHOP: TDO2 | |
| ligand binding site mutation search in PubMed: TDO2 | ||
| UCL Cancer Institute: TDO2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of TDO2 | Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage. Eur Rev Med Pharmacol Sci. 2009 Mar;13 Suppl 1:71-8. (pmid:19530515) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TDO2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.277452004 | -1.798434203 | 2.075886207 | 1.27E-11 | 8.66E-11 |
| BRCA | -0.803412183 | -4.333314814 | 3.529902632 | 1.83E-44 | 7.78E-43 |
| THCA | -2.628017342 | -4.209371579 | 1.581354237 | 1.36E-05 | 4.32E-05 |
| HNSC | -0.182374259 | -2.704948678 | 2.522574419 | 3.99E-08 | 4.23E-07 |
| LIHC | 4.728298624 | 8.027482624 | -3.299184 | 1.25E-10 | 1.61E-09 |
| STAD | -0.936126876 | -2.595683126 | 1.65955625 | 0.00121 | 0.006156765 |
| ESCA | 0.367124261 | -4.248248467 | 4.615372727 | 2.51E-05 | 0.001388764 |
| BLCA | -0.375402534 | -3.146270955 | 2.770868421 | 0.000123 | 0.001296455 |
| LUSC | 0.585703762 | -0.548523689 | 1.134227451 | 0.000654 | 0.001243926 |
| COAD | -0.08053553 | -1.522908606 | 1.442373077 | 0.000337 | 0.00108265 |
| KIRC | -2.097844931 | -3.291124098 | 1.193279167 | 0.000102 | 0.000214229 |
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| TissGene-miRNA for TDO2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TDO2 |
| TissGeneSNV for TDO2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q197H | LUAD | 2 |
| p.E69G | UCEC | 1 |
| p.K16X | STAD | 1 |
| p.T384S | LUAD | 1 |
| p.L90M | LGG | 1 |
| p.L204* | LUAD | 1 |
| p.D139H | ACC | 1 |
| p.R178I | STAD | 1 |
| p.M331R | COAD | 1 |
| p.H179L | LGG | 1 |
| p.R334K | HNSC | 1 |
| p.S345F | SKCM | 1 |
| p.Y359C | PAAD | 1 |
| p.K164N | READ | 1 |
| p.T30A | BRCA | 1 |
| p.V167A | COAD | 1 |
| p.R272G | LUAD | 1 |
| p.G337V | ESCA | 1 |
| p.G219R | SKCM | 1 |
| p.K16T | STAD | 1 |
| p.K27N | COAD | 1 |
| p.E404* | LUAD | 1 |
| p.E89D | LUAD | 1 |
| p.G38R | SKCM | 1 |
| p.N382K | STAD | 1 |
| p.Y399* | LUAD | 1 |
| p.E236K | SKCM | 1 |
| p.R117Q | DLBC | 1 |
| p.G31A | HNSC | 1 |
| p.G22C | THCA | 1 |
| p.G337D | UCEC | 1 |
| p.L202M | READ | 1 |
| p.E270K | SKCM | 1 |
| p.M294L | BLCA | 1 |
| p.G337D | STAD | 1 |
| p.R172T | LUSC | 1 |
| p.L71I | COAD | 1 |
| p.G43E | SKCM | 1 |
| p.S319L | SKCM | 1 |
| p.L365V | COAD | 1 |
| p.D142Y | UCEC | 1 |
| p.M171I | COAD | 1 |
| p.H386Q | SKCM | 1 |
| p.A35T | READ | 1 |
| p.R211I | READ | 1 |
| p.E187D | STAD | 1 |
| p.Q197K | HNSC | 1 |
| p.T134M | THYM | 1 |
| p.R272C | PRAD | 1 |
| p.L202M | ESCA | 1 |
| p.L192V | KIRP | 1 |
| p.I317T | BLCA | 1 |
| p.K16* | STAD | 1 |
| p.G8E | LUSC | 1 |
| p.R181C | SKCM | 1 |
| p.R181L | BLCA | 1 |
| p.S401G | STAD | 1 |
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| TissGeneCNV for TDO2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TDO2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG314637 | TDO2-GZMB | chr4:156830093 | chr14:25101153 |
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| TissGeneNet for TDO2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| COAD (tumor) | COAD (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| KICH (tumor) | KICH (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| STAD (tumor) | STAD (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| THCA (tumor) | THCA (normal) |
| TDO2, SIRT3, ASMTL (tumor) | TDO2, SIRT3, ASMTL (normal) |
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| TissGeneProg for TDO2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TDO2 |
| TissGeneDrug for TDO2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TDO2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0041696 | Unipolar Depression | 13 | BeFree |
| umls:C1269683 | Major Depressive Disorder | 13 | BeFree |
| umls:C0003469 | Anxiety Disorders | 9 | BeFree |
| umls:C0011570 | Mental Depression | 9 | BeFree |
| umls:C0011581 | Depressive disorder | 9 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 9 | BeFree |
| umls:C0036341 | Schizophrenia | 8 | BeFree,GAD |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 7 | BeFree |
| umls:C0005586 | Bipolar Disorder | 7 | BeFree,GAD |
| umls:C0004352 | Autistic Disorder | 5 | BeFree,CTD_human,LHGDN |
| umls:C0852733 | Completed Suicide | 5 | BeFree |
| umls:C0004930 | Behavior Disorders | 4 | BeFree |
| umls:C0004936 | Mental disorders | 4 | BeFree |
| umls:C0086132 | Depressive Symptoms | 4 | BeFree |
| umls:C0028768 | Obsessive-Compulsive Disorder | 3 | BeFree |
| umls:C0033975 | Psychotic Disorders | 3 | BeFree |
| umls:C0040517 | Gilles de la Tourette syndrome | 3 | BeFree,GAD |
| umls:C0006012 | Borderline Personality Disorder | 2 | BeFree |
| umls:C0013473 | Eating Disorders | 2 | BeFree |
| umls:C0018817 | Atrial Septal Defects | 2 | BeFree |
| umls:C0036349 | Paranoid Schizophrenia | 2 | BeFree |
| umls:C0038436 | Post-Traumatic Stress Disorder | 2 | BeFree |
| umls:C0232600 | Self-induced vomiting | 2 | BeFree |
| umls:C0525045 | Mood Disorders | 2 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 2 | BeFree |
| umls:C0001956 | alcohol use disorder | 1 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0003125 | Anorexia Nervosa | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0011351 | Dental Enamel Hypoplasia | 1 | BeFree |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0015672 | Fatigue | 1 | BeFree |
| umls:C0019337 | Heroin Dependence | 1 | BeFree |
| umls:C0020505 | Hyperphagia | 1 | BeFree |
| umls:C0022104 | Irritable Bowel Syndrome | 1 | BeFree |
| umls:C0024523 | Malabsorption Syndrome | 1 | BeFree |
| umls:C0026850 | Muscular Dystrophy | 1 | BeFree |
| umls:C0031212 | Personality Disorders | 1 | BeFree |
| umls:C0032897 | Prader-Willi Syndrome | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | LHGDN |
| umls:C0038187 | Starvation | 1 | CTD_human |
| umls:C0038441 | Stress Disorders, Traumatic | 1 | BeFree |
| umls:C0038443 | Stress, Psychological | 1 | BeFree |
| umls:C0085400 | Neurofibrillary degeneration (morphologic abnormality) | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0220702 | SCHIZOPHRENIA 1 (disorder) | 1 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0338480 | Common Migraine | 1 | BeFree |
| umls:C0338908 | Mixed anxiety and depressive disorder | 1 | BeFree |
| umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
| umls:C0432306 | Ichthyosis Bullosa of Siemens | 1 | BeFree |
| umls:C0525041 | Neurobehavioral Manifestations | 1 | BeFree |
| umls:C0600104 | Obsessive compulsive behavior | 1 | BeFree |
| umls:C0865424 | Adult attention deficit hyperactivity disorder | 1 | BeFree |
| umls:C1519680 | Tumor Immunity | 1 | BeFree |
| umls:C1848140 | COGNITIVE FUNCTION 1, SOCIAL | 1 | BeFree |
| umls:C2129214 | Loose stool | 1 | BeFree |
| umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
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