TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TFF1
check button Gene summary
Basic gene informationGene symbolTFF1
Gene nametrefoil factor 1
SynonymsBCEI|D21S21|HP1.A|HPS2|pNR-2|pS2
CytomapUCSC genome browser: 21q22.3
Type of geneprotein-coding
RefGenesNM_003225.2,
Descriptionbreast cancer estrogen-inducible proteinbreast cancer estrogen-inducible sequencegastrointestinal trefoil protein pS2polypeptide P1.Aprotein pS2
Modification date20141222
dbXrefs MIM : 113710
HGNC : HGNC
Ensembl : ENSG00000160182
HPRD : 00219
Vega : OTTHUMG00000086799
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TFF1
BioGPS: 7031
PathwayNCI Pathway Interaction Database: TFF1
KEGG: TFF1
REACTOME: TFF1
Pathway Commons: TFF1
ContextiHOP: TFF1
ligand binding site mutation search in PubMed: TFF1
UCL Cancer Institute: TFF1
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Stomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STAD
Reference showing the relevant tissue of TFF1DNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers. J Korean Med Sci. 2010 Mar;25(3):405-17. doi: 10.3346/jkms.2010.25.3.405. Epub 2010 Feb 17. (pmid:20191040)
go to article
Description by TissGene annotationsFused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0032355response to estradiol15831516
GO:0032355response to estradiol15831516


Top
TissGeneExp for TFF1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-2.689288539-0.944978816-1.7443097225.09E-101.71E-09
LUAD1.114915101-2.0603917953.1753068972.81E-081.19E-07
KICH-2.8107987610.184657239-2.9954562.58E-071.08E-06
HNSC-1.8308130860.165726448-1.9965395350.0007470.002630282
BRCA5.6866506433.9282585371.7583921050.0005660.001141113
KIRP-2.655148261-1.052167011-1.602981255.68E-050.000205728


Top
TissGene-miRNA for TFF1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for TFF1
TissGeneSNV for TFF1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A26TSKCM1
p.G55SSKCM1
p.M17VBLCA1
p.G21SSKCM1
p.Q50*SKCM1
p.S16FSKCM1
p.V62ISKCM1
p.R36CSKCM1


Top
TissGeneCNV for TFF1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for TFF1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABM786342TFF1-RALBchr21:43786638chr2:121036327
Chimerdb3.0FusionScanESCATCGA-L5-A891-01AZNF295-TFF15'UTR-CDSchr21:43430360chr21:43783516
Chimerdb3.0FusionScanESCATCGA-L5-A891-01AZNF295-TFF15'UTR-CDSchr21:43423005chr21:43783516
TCGAfusionPortalPRADALUADTCGA-97-7552-01ATFF1-RABEP1NAChr21:43782391Chr17:5283828


Top
TissGeneNet for TFF1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (tumor)TFF1, SP1, ESR1, POLR2A, HNRNPA1, TCEB3, UBQLN1, SP3, PSMB9, UBQLN4, PRKCZ, TAB2, AHR, ESR2, GKN2, PTRF, BTNL8, SIGLEC8, FCRL4, CD300LD, BTN3A1 (normal)
bullet pointbullet point


Top
TissGeneProg for TFF1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for TFF1
TissGeneDrug for TFF1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for TFF1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast58BeFree
umls:C0678222Breast Carcinoma54BeFree
umls:C0699791Stomach Carcinoma29BeFree,MGD
umls:C0024623Malignant neoplasm of stomach26BeFree
umls:C0596263Carcinogenesis18BeFree
umls:C0038356Stomach Neoplasms10BeFree,LHGDN
umls:C0079504Hermanski-Pudlak Syndrome7BeFree
umls:C0001418Adenocarcinoma5BeFree,LHGDN
umls:C0001430Adenoma5BeFree,LHGDN
umls:C0027627Neoplasm Metastasis5BeFree
umls:C0242994Hantavirus Infections5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0038358Gastric ulcer4BeFree,RGD
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C1458155Mammary Neoplasms4BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0032927Precancerous Conditions3BeFree,LHGDN
umls:C0206698Cholangiocarcinoma3BeFree,LHGDN
umls:C0009324Ulcerative Colitis2BeFree
umls:C0009404Colorectal Neoplasms2BeFree,LHGDN
umls:C0010346Crohn Disease2BeFree
umls:C0023530Leukopenia2BeFree
umls:C0027947Neutropenia2BeFree
umls:C0032584polyps2BeFree,LHGDN
umls:C0035335Retinoblastoma2BeFree
umls:C0078918Albinism, Oculocutaneous2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0206062Lung Diseases, Interstitial2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree,GAD
umls:C0333983Hyperplastic Polyp2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C0001075Achlorhydria1RGD
umls:C0001916Albinism1BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0002622Amnesia1BeFree
umls:C0005684Malignant neoplasm of urinary bladder1GAD
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007130Mucinous Adenocarcinoma1LHGDN
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0007965Chediak-Higashi Syndrome1BeFree
umls:C0009319Colitis1RGD
umls:C0010633Cystadenoma1BeFree
umls:C0017152Gastritis1BeFree
umls:C0017178Gastrointestinal Diseases1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0021390Inflammatory Bowel Diseases1LHGDN
umls:C0022650Kidney Calculi1GAD
umls:C0022658Kidney Diseases1GAD
umls:C0024115Lung diseases1BeFree
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0024291Lymphohistiocytosis, Hemophagocytic1BeFree
umls:C0024668Mammary Neoplasms, Experimental1CTD_human
umls:C0027430Nasal Polyps1BeFree
umls:C0030920Peptic Ulcer1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0038454Cerebrovascular accident1GAD
umls:C0038525Subarachnoid Hemorrhage1GAD
umls:C0079487Helicobacter Infections1BeFree
umls:C0085695Chronic gastritis1BeFree
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0149826Gastric adenoma1BeFree
umls:C0151699Intracranial Hemorrhages1GAD
umls:C0152018Esophageal carcinoma1BeFree
umls:C0221023Cyclic neutropenia1BeFree
umls:C0236053Mucosal ulcer1BeFree
umls:C0238033Carcinoma of Male Breast1BeFree
umls:C0238462Medullary carcinoma of thyroid1BeFree
umls:C0242488Acute Lung Injury1CTD_human
umls:C0267111Gastric dysplasia1BeFree
umls:C0267952Fibrosis of pancreas1BeFree
umls:C0276496Familial Alzheimer Disease (FAD)1BeFree
umls:C0278601Inflammatory Breast Carcinoma1BeFree
umls:C0279628Adenocarcinoma Of Esophagus1BeFree
umls:C0279680Transitional cell carcinoma of bladder1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0598935Tumor Initiation1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0751295Memory Loss1BeFree
umls:C0751778Myoclonic Epilepsies, Progressive1BeFree
umls:C0751785Unverricht-Lundborg Syndrome1BeFree
umls:C0858252Breast adenocarcinoma1BeFree
umls:C0878500Intraepithelial Neoplasia1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C1297882Partial Trisomy1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2936349Plaque, Amyloid1BeFree
umls:C2937358Cerebral Hemorrhage1GAD
umls:C3669246Mammary adenocarcinoma1BeFree