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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TPMT
check button Gene summary
Basic gene informationGene symbolTPMT
Gene namethiopurine S-methyltransferase
Synonyms-
CytomapUCSC genome browser: 6p22.3
Type of geneprotein-coding
RefGenesNM_000367.3,
DescriptionS-adenosyl-L-methionine:thiopurine S-methyltransferase
Modification date20141222
dbXrefs MIM : 187680
HGNC : HGNC
Ensembl : ENSG00000137364
HPRD : 01760
Vega : OTTHUMG00000014317
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TPMT
BioGPS: 7172
PathwayNCI Pathway Interaction Database: TPMT
KEGG: TPMT
REACTOME: TPMT
Pathway Commons: TPMT
ContextiHOP: TPMT
ligand binding site mutation search in PubMed: TPMT
UCL Cancer Institute: TPMT
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLTHCA
Reference showing the relevant tissue of TPMT
Description by TissGene annotationsTissgsLTS
Fused withTSGene
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for TPMT

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH1.2005505422.704142542-1.5035921.34E-111.25E-10


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TissGene-miRNA for TPMT

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for TPMT
TissGeneSNV for TPMT

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.L138IREAD1
p.S129LSKCM1
p.K176NUCEC1
p.E98*UCEC1
p.E114KBLCA1
p.L138IESCA1
p.D54YLUAD1
p.Q30RREAD1
p.K119TUCEC1
p.R226QLUAD1
p.G209SSKCM1
p.S124FSKCM1
p.E225QESCA1
p.H227RSARC1
p.E28QSTAD1
p.R215CCOAD1


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TissGeneCNV for TPMT

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for TPMT

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABU608204TPMT-PHACTR2chr6:18130276chr6:144148681
Chimerdb3.0FusionScanESCATCGA-L5-A4OW-01ATPMT-BTBD9In-Framechr6:18149218chr6:38312869
TCGAfusionPortalPRADABRCATCGA-A2-A0CX-01AKIF13A-TPMTIn-frameChr6:17987285Chr6:18134120
TCGAfusionPortalPRADABRCATCGA-C8-A12U-01ARANBP9-TPMTCDS-5UTRChr6:13711167Chr6:18149402
TCGAfusionPortalPRADAOVTCGA-13-0714-01ANF1-TPMTCDS-5UTRChr17:29422387Chr6:18149402


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TissGeneNet for TPMT

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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COAD (tumor)COAD (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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HNSC (tumor)HNSC (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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KICH (tumor)KICH (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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KIRC (tumor)KIRC (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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KIRP (tumor)KIRP (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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LIHC (tumor)LIHC (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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LUAD (tumor)LUAD (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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LUSC (tumor)LUSC (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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PRAD (tumor)PRAD (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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STAD (tumor)STAD (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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THCA (tumor)THCA (normal)
TPMT, RELA, TLN1 (tumor)TPMT, RELA, TLN1 (normal)
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TissGeneProg for TPMT

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for TPMT
TissGeneDrug for TPMT

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB01250OlsalazineInhibitorSmall moleculeApproved


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TissGeneDisease for TPMT

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0021390Inflammatory Bowel Diseases50BeFree,GAD,LHGDN
umls:C0023449Acute lymphocytic leukemia44BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma39BeFree,GAD,LHGDN
umls:C0023530Leukopenia34BeFree,CTD_human,GAD
umls:C0854467Myelosuppression30BeFree
umls:C0023418leukemia15BeFree,GAD
umls:C0342801Thiopurine S methyltranferase deficiency14BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT
umls:C0023452Leukemia, Lymphocytic, Acute, L113BeFree
umls:C0010346Crohn Disease11BeFree,GAD
umls:C0027947Neutropenia6BeFree,CTD_human,GAD
umls:C0085669Acute leukemia6BeFree
umls:C0004364Autoimmune Diseases5BeFree,GAD
umls:C0009324Ulcerative Colitis5BeFree,GAD
umls:C0023467Leukemia, Myelocytic, Acute5BeFree,GAD
umls:C0024141Lupus Erythematosus, Systemic5BeFree
umls:C0241910Hepatitis, Autoimmune4BeFree
umls:C0948168Bone marrow toxicity4BeFree
umls:C0023895Liver diseases3BeFree,GAD,LHGDN
umls:C0035435Rheumatism3BeFree,GAD
umls:C0242596Neoplasm, Residual3BeFree,LHGDN
umls:C0001824Agranulocytosis2BeFree
umls:C0003873Rheumatoid Arthritis2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2GAD
umls:C0013182Drug Allergy2GAD
umls:C0013221Drug toxicity2GAD
umls:C0018939Hematological Disease2GAD
umls:C0027498Nausea and vomiting2BeFree
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0037274Dermatologic disorders2BeFree,GAD
umls:C0085183Neoplasms, Second Primary2GAD
umls:C0155552Hearing Loss, Mixed Conductive-Sensorineural2BeFree
umls:C0206157Myopathies, Nemaline2GAD
umls:C0746883Febrile Neutropenia2BeFree
umls:C0003864Arthritis1GAD
umls:C0005956Bone Marrow Diseases1GAD
umls:C0006118Brain Neoplasms1BeFree,GAD
umls:C0006142Malignant neoplasm of breast1GAD
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0012860DNA Damage1GAD
umls:C0017181Gastrointestinal Hemorrhage1GAD
umls:C0019156Hepatic Veno-Occlusive Disease1BeFree
umls:C0019693HIV Infections1GAD
umls:C0020507Hyperplasia1LHGDN
umls:C0023448Lymphoid leukemia1BeFree
umls:C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1GAD
umls:C0024314Lymphoproliferative Disorders1GAD
umls:C0026769Multiple Sclerosis1BeFree,LHGDN
umls:C0030805Bullous pemphigoid1BeFree
umls:C0033027Preleukemia1BeFree
umls:C0037275Skin Diseases, Vesiculobullous1GAD
umls:C0042721Viral hepatitis1BeFree
umls:C0278704Malignant Childhood Neoplasm1BeFree
umls:C0280745secondary myelodysplastic syndromes1BeFree
umls:C0376545Hematologic Neoplasms1BeFree,GAD
umls:C0409974Lupus Erythematosus1GAD
umls:C0568062Methotrexate poisoning1GAD
umls:C0598766Leukemogenesis1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C0920028Leukaemia recurrent1BeFree
umls:C0948441Venoocclusive disease1BeFree
umls:C0949690Spondylarthritis1BeFree
umls:C1527249Colorectal Cancer1GAD
umls:C1840451MULTICYSTIC RENAL DYSPLASIA, BILATERAL1BeFree
umls:C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1GAD
umls:C2697368Gastrointestinal irritation1BeFree
umls:C2750088HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO1CTD_human,ORPHANET
umls:C2919828Chronic ulcerative colitis1GAD
umls:C3463824MYELODYSPLASTIC SYNDROME1BeFree