 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SLC7A5 |
 Gene summary |
| Basic gene information | Gene symbol | SLC7A5 |
| Gene name | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | |
| Synonyms | 4F2LC|CD98|D16S469E|E16|LAT1|MPE16|hLAT1 | |
| Cytomap | UCSC genome browser: 16q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003486.5, | |
| Description | 4F2 LC4F2 light chainCD98 light chainL-type amino acid transporter 1integral membrane protein E16large neutral amino acids transporter 1large neutral amino acids transporter small subunit 1sodium-independent neutral amino acid transporter LAT1solu | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 600182 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000103257 | ||
| HPRD : 02552 | ||
| Vega : OTTHUMG00000137658 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC7A5 | |
| BioGPS: 8140 | ||
| Pathway | NCI Pathway Interaction Database: SLC7A5 | |
| KEGG: SLC7A5 | ||
| REACTOME: SLC7A5 | ||
| Pathway Commons: SLC7A5 | ||
| Context | iHOP: SLC7A5 | |
| ligand binding site mutation search in PubMed: SLC7A5 | ||
| UCL Cancer Institute: SLC7A5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
| Reference showing the relevant tissue of SLC7A5 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SLC7A5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 4.875596156 | 3.426821737 | 1.448774419 | 1.27E-06 | 9.34E-06 |
| LUSC | 3.227604045 | 0.08944326 | 3.138160784 | 2.34E-24 | 4.62E-23 |
| BRCA | 1.537263333 | -0.447624387 | 1.984887719 | 4.29E-20 | 3.06E-19 |
| LUAD | 1.974007222 | -0.277546226 | 2.251553448 | 1.60E-19 | 2.99E-18 |
| COAD | 2.972274331 | -0.025537207 | 2.997811538 | 4.22E-19 | 1.16E-16 |
| KICH | -0.725997053 | 1.205094947 | -1.931092 | 0.000107 | 0.000277445 |
| Top |
| TissGene-miRNA for SLC7A5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SLC7A5 |
| TissGeneSNV for SLC7A5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S307L | SARC | 1 |
| p.F231L | COAD | 1 |
| p.P428S | STAD | 1 |
| p.V148L | KIRP | 1 |
| p.T194N | THYM | 1 |
| p.L101F | STAD | 1 |
| p.S126W | BLCA | 1 |
| p.R427W | LGG | 1 |
| p.L227V | BRCA | 1 |
| p.A448T | KIRP | 1 |
| p.L251I | PAAD | 1 |
| p.V123A | UCEC | 1 |
| p.A448T | COAD | 1 |
| p.E265K | HNSC | 1 |
| p.E136Q | BLCA | 1 |
| p.S308C | UCEC | 1 |
| p.V56L | LUSC | 1 |
| p.V311M | UCEC | 1 |
| p.L251I | PRAD | 1 |
| p.P360L | LGG | 1 |
| p.V494I | COAD | 1 |
| p.I68M | BLCA | 1 |
| p.E309X | KIRC | 1 |
| p.A209T | DLBC | 1 |
| p.G65S | UCEC | 1 |
| p.L182I | ESCA | 1 |
| p.V396I | STAD | 1 |
| p.F490L | LUAD | 1 |
| p.A312S | GBM | 1 |
| p.Y124F | BLCA | 1 |
| p.T345I | PRAD | 1 |
| p.F462L | UCEC | 1 |
| p.G235D | LGG | 1 |
| p.P373S | STAD | 1 |
| p.L133I | SARC | 1 |
| p.V313M | GBM | 1 |
| p.P270L | SKCM | 1 |
| p.E234K | BLCA | 1 |
| p.F439C | PAAD | 1 |
| p.T507A | UCEC | 1 |
| p.E506D | STAD | 1 |
| p.G316R | STAD | 1 |
| p.I64V | KIRC | 1 |
| Top |
| TissGeneCNV for SLC7A5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SLC7A5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF369111 | SLC7A5-KDM6A | chr16:87883161 | chrX:44873850 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ377733 | SLC7A5-ZNF76 | chr16:87863774 | chr6:35263501 | |
| Chimerdb3.0 | FusionScan | SARC | TCGA-FX-A2QS-01A | SLC7A5-NOS1AP | Out-of-Frame | chr16:87902490 | chr1:162124194 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A8W5-01B | SLC7A5-TMEM219 | CDS-5'UTR | chr16:87872319 | chr16:29974430 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-AA7I-01A | DIP2C-SLC7A5 | In-Frame | chr10:735433 | chr16:87885455 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-Z6-A8JD-01A | SLC7A5-SMG1 | Out-of-Frame | chr16:87902490 | chr16:18908278 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-38-4630-01A | BANP-SLC7A5 | 5'UTR-CDS | chr16:87985121 | chr16:87874761 |
| Top |
| TissGeneNet for SLC7A5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SLC7A5, ELAVL1, UBC, SLC3A2 (tumor) | SLC7A5, ELAVL1, UBC, SLC3A2 (normal) |
 |  |
| Top |
| TissGeneProg for SLC7A5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SLC7A5 |
| TissGeneDrug for SLC7A5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SLC7A5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
| umls:C1396243 | Intolerance to protein | 4 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
| umls:C0017636 | Glioblastoma | 3 | BeFree |
| umls:C0026764 | Multiple Myeloma | 3 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 3 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 3 | BeFree |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0010691 | Cystinuria | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 2 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree,LHGDN |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | LHGDN |
| umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0020507 | Hyperplasia | 1 | LHGDN |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0031485 | Phenylketonurias | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0079748 | Precursor cell lymphoblastic lymphoma | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| umls:C0178238 | Intestinal infectious disease (disorder) | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0205734 | Diabetes, Autoimmune | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | LHGDN |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0740277 | Bile duct carcinoma | 1 | BeFree |
| umls:C0751434 | Classical phenylketonuria | 1 | BeFree |
| umls:C0751435 | Hyperphenylalaninaemia | 1 | BeFree |
| umls:C0751571 | Cancer of Urinary Tract | 1 | BeFree |
| umls:C0920421 | cancer regression | 1 | BeFree |
| umls:C1370800 | Bile duct adenocarcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |