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| TissGeneSummary for GSG1 |
 Gene summary |
| Basic gene information | Gene symbol | GSG1 |
| Gene name | germ cell associated 1 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12p13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080554.2, NM_001080555.2,NM_001206842.1,NM_001206843.1,NM_001206845.1, NM_031289.3,NM_153823.3, | |
| Description | germ cell-specific gene 1 protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000111305 | ||
| HPRD : 11015 | ||
| Vega : OTTHUMG00000150148 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSG1 | |
| BioGPS: 83445 | ||
| Pathway | NCI Pathway Interaction Database: GSG1 | |
| KEGG: GSG1 | ||
| REACTOME: GSG1 | ||
| Pathway Commons: GSG1 | ||
| Context | iHOP: GSG1 | |
| ligand binding site mutation search in PubMed: GSG1 | ||
| UCL Cancer Institute: GSG1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
| Reference showing the relevant tissue of GSG1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GSG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.021542613 | 2.898257387 | -2.9198 | 7.71E-10 | 4.97E-09 |
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| TissGene-miRNA for GSG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GSG1 |
| TissGeneSNV for GSG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E103K | SKCM | 2 |
| p.Q318K | STAD | 1 |
| p.E64K | BLCA | 1 |
| p.Q78K | LUAD | 1 |
| p.F240L | BLCA | 1 |
| p.F276L | STAD | 1 |
| p.L232V | STAD | 1 |
| p.P187S | SKCM | 1 |
| p.R160K | STAD | 1 |
| p.D3H | BLCA | 1 |
| p.H184Y | BLCA | 1 |
| p.R264W | SKCM | 1 |
| p.P286H | LUAD | 1 |
| p.R100W | KIRP | 1 |
| p.L17I | HNSC | 1 |
| p.D331N | STAD | 1 |
| p.G303S | COAD | 1 |
| p.D270N | PAAD | 1 |
| p.P288L | UCEC | 1 |
| p.Q306K | SARC | 1 |
| p.L148Q | COAD | 1 |
| p.R243C | THYM | 1 |
| p.H184Y | LUAD | 1 |
| p.S7L | BLCA | 1 |
| p.A260V | UCEC | 1 |
| p.D234N | PAAD | 1 |
| p.E51K | BLCA | 1 |
| p.V274L | LUAD | 1 |
| p.P61S | CESC | 1 |
| p.D151N | SKCM | 1 |
| p.Q172X | COAD | 1 |
| p.E110K | SKCM | 1 |
| p.A211T | PRAD | 1 |
| p.S5Y | THYM | 1 |
| p.E102K | HNSC | 1 |
| p.R87W | KIRP | 1 |
| p.W252L | HNSC | 1 |
| p.E115K | HNSC | 1 |
| p.F341L | UCEC | 1 |
| p.R180X | STAD | 1 |
| p.T265I | LIHC | 1 |
| p.V11A | UCEC | 1 |
| p.C101F | SKCM | 1 |
| p.F23V | UCEC | 1 |
| p.E131K | SKCM | 1 |
| p.Q172K | ESCA | 1 |
| p.S89P | MESO | 1 |
| p.S172F | SKCM | 1 |
| p.K249T | LGG | 1 |
| p.G183R | SKCM | 1 |
| p.D3N | STAD | 1 |
| p.D3Y | UCEC | 1 |
| p.G147R | SKCM | 1 |
| p.S105R | STAD | 1 |
| p.R91W | COAD | 1 |
| p.L6I | LUAD | 1 |
| p.M184I | SKCM | 1 |
| p.F276L | BLCA | 1 |
| p.W216L | HNSC | 1 |
| p.G201V | COAD | 1 |
| p.E167K | SKCM | 1 |
| p.S7P | BLCA | 1 |
| p.V63L | HNSC | 1 |
| p.E275* | UCEC | 1 |
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| TissGeneCNV for GSG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GSG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI016246 | LOC440934-GSG1 | chr2:223186375 | chr12:13241798 |
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| TissGeneNet for GSG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for GSG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GSG1 |
| TissGeneDrug for GSG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GSG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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