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| TissGeneSummary for FAM186B |
 Gene summary |
| Basic gene information | Gene symbol | FAM186B |
| Gene name | family with sequence similarity 186, member B | |
| Synonyms | C12orf25 | |
| Cytomap | UCSC genome browser: 12q13.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_032130.2, NR_027450.1, | |
| Description | protein FAM186B | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000135436 | ||
| HPRD : 08535 | ||
| Vega : OTTHUMG00000167427 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FAM186B | |
| BioGPS: 84070 | ||
| Pathway | NCI Pathway Interaction Database: FAM186B | |
| KEGG: FAM186B | ||
| REACTOME: FAM186B | ||
| Pathway Commons: FAM186B | ||
| Context | iHOP: FAM186B | |
| ligand binding site mutation search in PubMed: FAM186B | ||
| UCL Cancer Institute: FAM186B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of FAM186B | ||
| Description by TissGene annotations | Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FAM186B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 1.593960048 | 0.375952048 | 1.218008 | 7.19E-07 | 2.76E-06 |
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| TissGene-miRNA for FAM186B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FAM186B |
| TissGeneSNV for FAM186B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I663T | LGG | 1 |
| p.E542D | PAAD | 1 |
| p.G639E | STAD | 1 |
| p.V150A | LUAD | 1 |
| p.A209V | COAD | 1 |
| p.T646A | LIHC | 1 |
| p.W410R | LUAD | 1 |
| p.I753T | LGG | 1 |
| p.E477D | COAD | 1 |
| p.G90E | SKCM | 1 |
| p.M205I | ESCA | 1 |
| p.Q8P | LGG | 1 |
| p.S399L | UCEC | 1 |
| p.A579V | STAD | 1 |
| p.V240A | LUAD | 1 |
| p.E356Q | BRCA | 1 |
| p.E452D | PAAD | 1 |
| p.T737M | SKCM | 1 |
| p.L751M | LGG | 1 |
| p.M354V | COAD | 1 |
| p.A237V | STAD | 1 |
| p.E321Q | LUAD | 1 |
| p.R876Q | STAD | 1 |
| p.E549D | UCEC | 1 |
| p.R308H | LGG | 1 |
| p.I115T | BLCA | 1 |
| p.R82H | UCS | 1 |
| p.P361Q | COAD | 1 |
| p.E345D | UCEC | 1 |
| p.R531W | HNSC | 1 |
| p.F368L | BRCA | 1 |
| p.R621Q | COAD | 1 |
| p.A437V | SARC | 1 |
| p.P830T | THYM | 1 |
| p.V230D | OV | 1 |
| p.M220I | BLCA | 1 |
| p.V535I | BRCA | 1 |
| p.M205T | STAD | 1 |
| p.A655V | UCEC | 1 |
| p.R51H | LUAD | 1 |
| p.G848R | LUAD | 1 |
| p.R689C | READ | 1 |
| p.I289M | SKCM | 1 |
| p.L308F | LUSC | 1 |
| p.R643Q | READ | 1 |
| p.K769N | UCEC | 1 |
| p.P361L | STAD | 1 |
| p.R755S | STAD | 1 |
| p.S186Y | READ | 1 |
| p.R255S | DLBC | 1 |
| p.A64V | PRAD | 1 |
| p.R731C | SKCM | 1 |
| p.P139A | STAD | 1 |
| p.K788N | UCEC | 1 |
| p.R166K | STAD | 1 |
| p.P502S | HNSC | 1 |
| p.E324D | LIHC | 1 |
| p.I25T | BLCA | 1 |
| p.A489V | STAD | 1 |
| p.G881R | SKCM | 1 |
| p.I385M | KIRP | 1 |
| p.E253Q | HNSC | 1 |
| p.E391Q | LUAD | 1 |
| p.R76K | STAD | 1 |
| p.E163K | SKCM | 1 |
| p.E71K | BLCA | 1 |
| p.E498D | STAD | 1 |
| p.T114S | LUAD | 1 |
| p.A126T | LUAD | 1 |
| p.I233T | UCEC | 1 |
| p.S677N | STAD | 1 |
| p.P697L | SARC | 1 |
| p.M205I | BRCA | 1 |
| p.E315D | UCEC | 1 |
| p.L598M | PRAD | 1 |
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| TissGeneCNV for FAM186B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FAM186B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-HT-A617-01A | PARK7-FAM186B | Out-of-Frame | chr1:8030998 | chr12:49989231 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7736-01A | PARK7-FAM186B | In-Frame | chr1:8025447 | chr12:49988964 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-B6-A0IC-01A | PARK7-FAM186B | In-Frame | chr1:8025447 | chr12:49988964 |
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| TissGeneNet for FAM186B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FAM186B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FAM186B |
| TissGeneDrug for FAM186B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FAM186B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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