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| TissGeneSummary for RIMBP3 |
 Gene summary |
| Basic gene information | Gene symbol | RIMBP3 |
| Gene name | RIMS binding protein 3 | |
| Synonyms | RIM-BP3|RIM-BP3.1|RIM-BP3.A|RIMBP3.1|RIMBP3A | |
| Cytomap | UCSC genome browser: 22q11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015672.1, | |
| Description | RIMS binding protein 3.1RIMS-binding protein 3A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612699 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000275793 | ||
| Vega : OTTHUMG00000188355 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RIMBP3 | |
| BioGPS: 85376 | ||
| Pathway | NCI Pathway Interaction Database: RIMBP3 | |
| KEGG: RIMBP3 | ||
| REACTOME: RIMBP3 | ||
| Pathway Commons: RIMBP3 | ||
| Context | iHOP: RIMBP3 | |
| ligand binding site mutation search in PubMed: RIMBP3 | ||
| UCL Cancer Institute: RIMBP3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of RIMBP3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RIMBP3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -1.490510584 | -2.682040584 | 1.19153 | 1.06E-06 | 5.63E-06 |
| HNSC | -0.070251374 | -1.433216491 | 1.362965116 | 2.23E-06 | 1.54E-05 |
| KIRC | 0.305693361 | -1.366834417 | 1.672527778 | 1.21E-25 | 1.51E-24 |
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| TissGene-miRNA for RIMBP3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RIMBP3 |
| TissGeneSNV for RIMBP3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T1071N | LIHC | 1 |
| p.Q998K | UCEC | 1 |
| p.A1036V | UCEC | 1 |
| p.R1019C | SKCM | 1 |
| p.D1079Y | SKCM | 1 |
| p.R1399K | PRAD | 1 |
| p.P1109S | SKCM | 1 |
| p.E1333K | SKCM | 1 |
| p.P890S | SKCM | 1 |
| p.A1345S | LUSC | 1 |
| p.L1379F | PRAD | 1 |
| p.H1376L | SKCM | 1 |
| p.I1011V | SARC | 1 |
| p.G943R | PRAD | 1 |
| p.E1263A | PAAD | 1 |
| p.E1381V | HNSC | 1 |
| p.R1059W | COAD | 1 |
| p.Y1041F | HNSC | 1 |
| p.G980C | PAAD | 1 |
| p.G1070E | SKCM | 1 |
| p.R403P | HNSC | 1 |
| p.F876L | BLCA | 1 |
| p.R1528M | UCEC | 1 |
| p.A1130V | HNSC | 1 |
| p.G879R | SKCM | 1 |
| p.R885W | HNSC | 1 |
| p.V991L | GBM | 1 |
| p.P996H | UCEC | 1 |
| p.P1307L | SKCM | 1 |
| p.H1189Y | CESC | 1 |
| p.E1333Q | KIRP | 1 |
| p.T1050M | GBM | 1 |
| p.K1473N | UCEC | 1 |
| p.G654R | ESCA | 1 |
| p.N1297S | UCEC | 1 |
| p.H1022N | THYM | 1 |
| p.R389S | HNSC | 1 |
| p.A591V | PAAD | 1 |
| p.Q1408K | LUAD | 1 |
| p.G1070R | CHOL | 1 |
| p.E1057K | BLCA | 1 |
| p.A1139S | LIHC | 1 |
| p.Q922* | HNSC | 1 |
| p.R1055W | LIHC | 1 |
| p.P890S | STAD | 1 |
| p.D1389N | SKCM | 1 |
| p.A1533V | ESCA | 1 |
| p.F1150L | UCEC | 1 |
| p.R1190* | UCEC | 1 |
| p.K1321N | SKCM | 1 |
| p.G1125S | BLCA | 1 |
| p.G862R | SKCM | 1 |
| p.G1442S | BRCA | 1 |
| p.G1413E | PAAD | 1 |
| p.P1307T | BRCA | 1 |
| p.P1086L | UCEC | 1 |
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| TissGeneCNV for RIMBP3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RIMBP3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for RIMBP3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for RIMBP3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RIMBP3 |
| TissGeneDrug for RIMBP3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RIMBP3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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