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| TissGeneSummary for KYNU |
 Gene summary |
| Basic gene information | Gene symbol | KYNU |
| Gene name | kynureninase | |
| Synonyms | KYNUU | |
| Cytomap | UCSC genome browser: 2q22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001032998.1, NM_001199241.1,NM_003937.2, | |
| Description | L-kynurenine hydrolase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605197 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115919 | ||
| HPRD : 08940 | ||
| Vega : OTTHUMG00000131829 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KYNU | |
| BioGPS: 8942 | ||
| Pathway | NCI Pathway Interaction Database: KYNU | |
| KEGG: KYNU | ||
| REACTOME: KYNU | ||
| Pathway Commons: KYNU | ||
| Context | iHOP: KYNU | |
| ligand binding site mutation search in PubMed: KYNU | ||
| UCL Cancer Institute: KYNU | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLIHC | |
| Reference showing the relevant tissue of KYNU | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019805 | quinolinate biosynthetic process | 9291104 | GO:0034341 | response to interferon-gamma | 9291104 | GO:0043420 | anthranilate metabolic process | 11985583 | GO:0019805 | quinolinate biosynthetic process | 9291104 | GO:0034341 | response to interferon-gamma | 9291104 | GO:0043420 | anthranilate metabolic process | 11985583 |
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| TissGeneExp for KYNU |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 1.729792646 | 3.302262646 | -1.57247 | 6.39E-06 | 2.83E-05 |
| ESCA | 0.301357737 | -2.505296808 | 2.806654545 | 0.00212 | 0.02334099 |
| HNSC | 1.638332367 | 0.093271902 | 1.545060465 | 6.88E-05 | 0.000323849 |
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| TissGene-miRNA for KYNU |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KYNU |
| TissGeneSNV for KYNU |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P166S | SKCM | 2 |
| p.G73E | SKCM | 2 |
| p.R155Q | SKCM | 2 |
| p.H32P | SKCM | 1 |
| p.K384N | UCEC | 1 |
| p.E197Q | LUAD | 1 |
| p.R358Q | READ | 1 |
| p.E130X | READ | 1 |
| p.L368V | LUAD | 1 |
| p.W265* | STAD | 1 |
| p.D250Y | HNSC | 1 |
| p.I110N | UCEC | 1 |
| p.G266R | SKCM | 1 |
| p.P108H | PAAD | 1 |
| p.D426Y | LUAD | 1 |
| p.K412E | COAD | 1 |
| p.E206K | SKCM | 1 |
| p.E90K | COAD | 1 |
| p.D459N | SKCM | 1 |
| p.R188W | PCPG | 1 |
| p.P234L | LIHC | 1 |
| p.S75Y | READ | 1 |
| p.K157N | UCEC | 1 |
| p.N127S | LUAD | 1 |
| p.W109X | SKCM | 1 |
| p.M120L | LUSC | 1 |
| p.H253N | SARC | 1 |
| p.G244D | SKCM | 1 |
| p.C425R | LIHC | 1 |
| p.G180E | SKCM | 1 |
| p.W265* | LUAD | 1 |
| p.N182Y | LUAD | 1 |
| p.R155* | LUAD | 1 |
| p.F305L | BRCA | 1 |
| p.V435L | ESCA | 1 |
| p.A136S | PRAD | 1 |
| p.E66Q | HNSC | 1 |
| p.M134I | READ | 1 |
| p.E89K | STAD | 1 |
| p.S75Y | STAD | 1 |
| p.A126T | SKCM | 1 |
| p.R330Q | SARC | 1 |
| p.G304E | SKCM | 1 |
| p.T406P | SKCM | 1 |
| p.A30S | LUAD | 1 |
| p.H142Q | MESO | 1 |
| p.R330X | PRAD | 1 |
| p.L199S | HNSC | 1 |
| p.V217M | STAD | 1 |
| p.H169Y | SKCM | 1 |
| p.N465K | COAD | 1 |
| p.S408F | UCS | 1 |
| p.R330* | PRAD | 1 |
| p.K150R | KICH | 1 |
| p.I204M | KIRP | 1 |
| p.L251Q | BLCA | 1 |
| p.E36K | SKCM | 1 |
| p.P166H | GBM | 1 |
| p.E35K | HNSC | 1 |
| p.D250H | OV | 1 |
| p.G287D | LUAD | 1 |
| p.V414A | UCEC | 1 |
| p.Y441H | KIRC | 1 |
| p.S221I | LUAD | 1 |
| p.R428G | CHOL | 1 |
| p.R358Q | SKCM | 1 |
| p.V223A | KICH | 1 |
| p.A352V | UCS | 1 |
| p.R434* | SKCM | 1 |
| p.W109* | SKCM | 1 |
| p.C45R | UCEC | 1 |
| p.R188W | THYM | 1 |
| p.K64E | KIRC | 1 |
| p.E128D | UCEC | 1 |
| p.G328* | LUAD | 1 |
| p.W265X | STAD | 1 |
| p.C271S | LUAD | 1 |
| p.S75C | ESCA | 1 |
| p.I208N | STAD | 1 |
| p.A126G | HNSC | 1 |
| p.E7Q | LUAD | 1 |
| p.D122E | LUAD | 1 |
| p.Q14K | LUSC | 1 |
| p.T152M | PRAD | 1 |
| p.G432V | SARC | 1 |
| p.G328E | LUAD | 1 |
| p.R399Q | HNSC | 1 |
| p.S443F | SKCM | 1 |
| p.Y448H | HNSC | 1 |
| p.C273F | LUAD | 1 |
| p.P334L | SKCM | 1 |
| p.W109C | LUAD | 1 |
| p.M316I | LUSC | 1 |
| p.L159F | SKCM | 1 |
| p.H308Y | SKCM | 1 |
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| TissGeneCNV for KYNU |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KYNU |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BP333200 | HTN1-KYNU | chr4:70924377 | chr2:143795116 | |
| Chimerdb3.0 | ChiTaRs | NA | BF997792 | TGOLN2-KYNU | chr2:85548146 | chr2:143725826 | |
| Chimerdb3.0 | ChiTaRs | NA | BF907726 | KYNU-KYNU | chr2:143743591 | chr2:143712379 | |
| Chimerdb3.0 | ChiTaRs | NA | CB851853 | KYNU-KYNU | chr2:143747106 | chr2:143746729 | |
| Chimerdb3.0 | FusionScan | LGG | TCGA-HT-7477-01B | PBRM1-KYNU | In-Frame | chr3:52692214 | chr2:143742652 |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7477-01B | PBRM1-KYNU | In-frame | Chr3:52692215 | Chr2:143742653 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-38-4630-01A | ARHGAP15-KYNU | In-frame | Chr2:144008169 | Chr2:143742653 |
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| TissGeneNet for KYNU |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| COAD (tumor) | COAD (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| KICH (tumor) | KICH (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| STAD (tumor) | STAD (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| THCA (tumor) | THCA (normal) |
| KYNU, UBC (tumor) | KYNU, UBC (normal) |
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| TissGeneProg for KYNU |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KYNU |
| TissGeneDrug for KYNU |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KYNU |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0021368 | Inflammation | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0085580 | Essential Hypertension | 1 | BeFree |
| umls:C0268474 | Hydroxykynureninuria | 1 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
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