 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CCDC74B |
 Gene summary |
| Basic gene information | Gene symbol | CCDC74B |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCDC74B | |
| BioGPS: 90557 | ||
| Pathway | NCI Pathway Interaction Database: CCDC74B | |
| KEGG: CCDC74B | ||
| REACTOME: CCDC74B | ||
| Pathway Commons: CCDC74B | ||
| Context | iHOP: CCDC74B | |
| ligand binding site mutation search in PubMed: CCDC74B | ||
| UCL Cancer Institute: CCDC74B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CCDC74B | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for CCDC74B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.311568415 | 0.406043585 | -3.717612 | 1.69E-10 | 1.23E-09 |
| LUAD | -2.000355863 | -0.649335174 | -1.35102069 | 0.000139 | 0.000342612 |
| Top |
| TissGene-miRNA for CCDC74B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for CCDC74B |
| TissGeneSNV for CCDC74B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E383K | SKCM | 1 |
| p.Q350* | LUAD | 1 |
| p.G170E | UCEC | 1 |
| p.S298L | SKCM | 1 |
| p.V327A | STAD | 1 |
| p.R280C | COAD | 1 |
| p.R267* | STAD | 1 |
| p.A69S | COAD | 1 |
| p.S171R | KIRP | 1 |
| p.G49R | LIHC | 1 |
| p.E208D | ACC | 1 |
| p.P312L | SKCM | 1 |
| p.R369Q | SKCM | 1 |
| p.S225Y | UCEC | 1 |
| p.Q326E | LUAD | 1 |
| p.N121D | ESCA | 1 |
| p.Q202H | STAD | 1 |
| p.Q393* | SKCM | 1 |
| p.P214S | SKCM | 1 |
| p.T120A | LUAD | 1 |
| p.E276K | COAD | 1 |
| p.G122R | HNSC | 1 |
| p.S317N | BLCA | 1 |
| p.P169L | ACC | 1 |
| p.S38R | PRAD | 1 |
| p.Q246X | SKCM | 1 |
| p.L118F | LUAD | 1 |
| p.P323S | SKCM | 1 |
| p.S331N | LIHC | 1 |
| p.Q119H | UCEC | 1 |
| p.L131F | CESC | 1 |
| p.V123A | ACC | 1 |
| p.A147T | PRAD | 1 |
| p.Q396L | HNSC | 1 |
| p.E310D | ACC | 1 |
| p.R228K | UCEC | 1 |
| p.P265S | SKCM | 1 |
| p.R267X | STAD | 1 |
| p.R369P | LUAD | 1 |
| p.R377H | UCEC | 1 |
| p.R374H | STAD | 1 |
| p.M252I | LUAD | 1 |
| p.G177R | SARC | 1 |
| p.T322M | BLCA | 1 |
| p.Q348* | SKCM | 1 |
| p.R138S | LUAD | 1 |
| p.Q88R | SARC | 1 |
| p.S204L | CESC | 1 |
| p.S273R | KIRP | 1 |
| p.R468S | LUAD | 1 |
| p.D260N | UCEC | 1 |
| p.E233D | STAD | 1 |
| p.A147T | BLCA | 1 |
| p.Q296K | ACC | 1 |
| p.S279F | SKCM | 1 |
| p.R232K | BRCA | 1 |
| p.T424M | BLCA | 1 |
| p.G224R | HNSC | 1 |
| p.E100K | CESC | 1 |
| p.G136E | SKCM | 1 |
| p.P418L | SKCM | 1 |
| p.Q291X | SKCM | 1 |
| p.M354I | LUAD | 1 |
| p.A334T | LGG | 1 |
| p.S192N | UCEC | 1 |
| p.Q194K | ACC | 1 |
| p.A175S | HNSC | 1 |
| p.G205E | SKCM | 1 |
| p.P418S | SKCM | 1 |
| p.G182C | UCEC | 1 |
| p.P114T | ACC | 1 |
| p.S177F | SKCM | 1 |
| p.G257D | BLCA | 1 |
| p.T94I | BRCA | 1 |
| p.A471P | LUSC | 1 |
| p.Q466* | LUAD | 1 |
| p.P201S | BRCA | 1 |
| p.R218H | CESC | 1 |
| p.P134L | ESCA | 1 |
| p.R179W | LUAD | 1 |
| p.P316L | SKCM | 1 |
| Top |
| TissGeneCNV for CCDC74B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CCDC74B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | CESC | TCGA-EA-A3QD-01A | CCDC74B-CCDC74A | In-Frame | chr2:130897595 | chr2:132290296 |
| Top |
| TissGeneNet for CCDC74B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for CCDC74B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CCDC74B |
| TissGeneDrug for CCDC74B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for CCDC74B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |