TissGeneSummary for ASIC3 |
Gene summary |
Basic gene information | Gene symbol | ASIC3 |
Gene name | acid-sensing (proton-gated) ion channel 3 | |
Synonyms | ACCN3|DRASIC|SLNAC1|TNaC1 | |
Cytomap | UCSC genome browser: 7q35 | |
Type of gene | protein-coding | |
RefGenes | NM_004769.3, NM_020321.3,NM_020322.3,NR_046401.1, | |
Description | acid-sensing ion channel 3amiloride-sensitive cation channel 3, testismodulatory subunit of ASIC2aneuronal amiloride-sensitive cation channel 3proton-gated cation channel subunittestis sodium channel 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611741 | |
HGNC : HGNC | ||
Ensembl : ENSG00000213199 | ||
HPRD : 10626 | ||
Vega : OTTHUMG00000158685 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ASIC3 | |
BioGPS: 9311 | ||
Pathway | NCI Pathway Interaction Database: ASIC3 | |
KEGG: ASIC3 | ||
REACTOME: ASIC3 | ||
Pathway Commons: ASIC3 | ||
Context | iHOP: ASIC3 | |
ligand binding site mutation search in PubMed: ASIC3 | ||
UCL Cancer Institute: ASIC3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ASIC3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ASIC3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ASIC3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ASIC3 |
TissGeneSNV for ASIC3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E219K | SKCM | 2 |
p.C543S | SKCM | 1 |
p.F144C | PAAD | 1 |
p.E421K | HNSC | 1 |
p.G195V | LUAD | 1 |
p.M528V | UCEC | 1 |
p.D281N | CESC | 1 |
p.V423M | COAD | 1 |
p.P293A | LIHC | 1 |
p.D77E | DLBC | 1 |
p.R165C | STAD | 1 |
p.R165C | COAD | 1 |
p.E430K | SKCM | 1 |
p.R494C | SKCM | 1 |
p.T103M | CESC | 1 |
p.P520L | SKCM | 1 |
p.N290S | LUAD | 1 |
p.G209R | HNSC | 1 |
p.S432L | LUSC | 1 |
p.G439E | SKCM | 1 |
p.P520L | STAD | 1 |
p.S112F | LUAD | 1 |
p.E320K | UCEC | 1 |
p.A417T | SKCM | 1 |
p.G195R | LUAD | 1 |
p.P520S | LGG | 1 |
p.P510H | LUAD | 1 |
p.R127H | ESCA | 1 |
p.A113V | STAD | 1 |
p.T4A | COAD | 1 |
p.D118N | SKCM | 1 |
p.M1T | LIHC | 1 |
p.G207S | LUSC | 1 |
p.R12Q | STAD | 1 |
p.S37R | LUAD | 1 |
p.A428V | KIRC | 1 |
p.E78K | HNSC | 1 |
p.R127C | KIRP | 1 |
p.P87L | PAAD | 1 |
p.P499S | CESC | 1 |
p.G546X | THYM | 1 |
p.E220K | BLCA | 1 |
p.V517L | SKCM | 1 |
p.A513V | LGG | 1 |
p.R480K | SKCM | 1 |
p.S519L | COAD | 1 |
p.N190T | SKCM | 1 |
p.P259S | OV | 1 |
p.L508V | CESC | 1 |
p.M213L | UCEC | 1 |
p.N349S | UCEC | 1 |
p.P277L | STAD | 1 |
p.S305R | LGG | 1 |
p.T55N | KIRC | 1 |
p.P520S | GBM | 1 |
p.V49M | PAAD | 1 |
p.R494C | HNSC | 1 |
p.H504Q | BLCA | 1 |
p.R522H | UCEC | 1 |
p.T422A | LIHC | 1 |
p.T177I | SKCM | 1 |
p.V49M | COAD | 1 |
p.F274V | COAD | 1 |
p.T358M | UCEC | 1 |
p.F70L | LGG | 1 |
p.R167H | HNSC | 1 |
p.E512K | COAD | 1 |
p.H72Q | LUSC | 1 |
p.P248S | UCEC | 1 |
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TissGeneCNV for ASIC3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ASIC3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA429417 | ASIC3-ASIC3 | chr7:150747842 | chr7:150745979 |
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TissGeneNet for ASIC3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ASIC3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ASIC3 |
TissGeneDrug for ASIC3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ASIC3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
umls:C0015672 | Fatigue | 2 | BeFree |
umls:C0151744 | Myocardial Ischemia | 2 | BeFree |
umls:C0003864 | Arthritis | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0011127 | Pressure Ulcer | 1 | BeFree |
umls:C0016053 | Fibromyalgia | 1 | BeFree |
umls:C0020429 | Hyperalgesia | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0021368 | Inflammation | 1 | CTD_human |
umls:C0021655 | Insulin Resistance | 1 | GAD |
umls:C0231528 | Myalgia | 1 | BeFree |
umls:C0234251 | Inflammatory pain | 1 | BeFree |
umls:C0262385 | Autonomic nervous system imbalance | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0751211 | Hyperalgesia, Primary | 1 | BeFree |