TissGeneSummary for A1BG |
Gene summary |
Basic gene information | Gene symbol | A1BG |
Gene name | alpha-1-B glycoprotein | |
Synonyms | A1B|ABG|GAB|HYST2477 | |
Cytomap | UCSC genome browser: 19q13.4 | |
Type of gene | protein-coding | |
RefGenes | NM_130786.3, | |
Description | HEL-S-163pAalpha-1B-glycoproteinepididymis secretory sperm binding protein Li 163pA | |
Modification date | 20141207 | |
dbXrefs | MIM : 138670 | |
HGNC : HGNC | ||
Ensembl : ENSG00000121410 | ||
HPRD : 00726 | ||
Vega : OTTHUMG00000183507 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_A1BG | |
BioGPS: 1 | ||
Pathway | NCI Pathway Interaction Database: A1BG | |
KEGG: A1BG | ||
REACTOME: A1BG | ||
Pathway Commons: A1BG | ||
Context | iHOP: A1BG | |
ligand binding site mutation search in PubMed: A1BG | ||
UCL Cancer Institute: A1BG | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of A1BG | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for A1BG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | -1.664039893 | -0.428436047 | -1.235603846 | 7.76E-09 | 9.94E-08 |
LIHC | 7.137020492 | 9.649960492 | -2.51294 | 7.18E-08 | 5.25E-07 |
KICH | -2.547003508 | -1.113267508 | -1.433736 | 1.63E-05 | 4.91E-05 |
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TissGene-miRNA for A1BG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for A1BG |
TissGeneSNV for A1BG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A191T | COAD | 2 |
p.K106* | HNSC | 1 |
p.L31Q | LIHC | 1 |
p.G225D | UCEC | 1 |
p.C182Y | COAD | 1 |
p.V138A | LIHC | 1 |
p.R90C | BRCA | 1 |
p.Q50* | HNSC | 1 |
p.R94H | THYM | 1 |
p.R254K | HNSC | 1 |
p.P113T | SARC | 1 |
p.H52Y | HNSC | 1 |
p.R245C | PRAD | 1 |
p.F264S | STAD | 1 |
p.E437D | SKCM | 1 |
p.F81L | LUAD | 1 |
p.P69L | LGG | 1 |
p.P296L | LIHC | 1 |
p.A268V | UCEC | 1 |
p.V6I | PAAD | 1 |
p.G466D | GBM | 1 |
p.G274R | HNSC | 1 |
p.L31M | LUAD | 1 |
p.G246R | BLCA | 1 |
p.S37* | BLCA | 1 |
p.R94H | ACC | 1 |
p.R261C | PAAD | 1 |
p.P162L | LUAD | 1 |
p.S193F | LIHC | 1 |
p.D260G | UCEC | 1 |
p.E481K | STAD | 1 |
p.D273N | STAD | 1 |
p.D187N | SKCM | 1 |
p.A295T | BRCA | 1 |
p.F241L | HNSC | 1 |
p.C182F | ESCA | 1 |
p.R94H | CESC | 1 |
p.E203Q | BLCA | 1 |
p.V297I | SKCM | 1 |
p.R185W | LUAD | 1 |
p.R261C | COAD | 1 |
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TissGeneCNV for A1BG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for A1BG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB162062 | A1BG-A1BG | chr19:58863007 | chr19:58858971 |
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TissGeneNet for A1BG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for A1BG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for A1BG |
TissGeneDrug for A1BG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for A1BG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0013080 | Down Syndrome | 1 | BeFree |
umls:C0015230 | Exanthema | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0848332 | Spots on skin | 1 | BeFree |