TissGeneSummary for CDH6 |
Gene summary |
Basic gene information | Gene symbol | CDH6 |
Gene name | cadherin 6, type 2, K-cadherin (fetal kidney) | |
Synonyms | CAD6|KCAD | |
Cytomap | UCSC genome browser: 5p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_004932.3, | |
Description | cadherin-6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603007 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113361 | ||
HPRD : 04305 | ||
Vega : OTTHUMG00000090673 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDH6 | |
BioGPS: 1004 | ||
Pathway | NCI Pathway Interaction Database: CDH6 | |
KEGG: CDH6 | ||
REACTOME: CDH6 | ||
Pathway Commons: CDH6 | ||
Context | iHOP: CDH6 | |
ligand binding site mutation search in PubMed: CDH6 | ||
UCL Cancer Institute: CDH6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyOvary | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHOV | |
Reference showing the relevant tissue of CDH6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CDH6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 4.74521445 | 2.274922784 | 2.470291667 | 8.38E-21 | 7.09E-20 |
LUSC | -1.122450664 | 0.26475914 | -1.387209804 | 2.61E-05 | 5.73E-05 |
THCA | 1.052331988 | -1.354591741 | 2.406923729 | 1.30E-16 | 2.25E-15 |
KICH | -1.359439605 | 1.027808395 | -2.387248 | 2.57E-07 | 1.08E-06 |
KIRP | 3.586615145 | 1.98936827 | 1.597246875 | 0.0011 | 0.003007561 |
COAD | -1.404938221 | -2.502865144 | 1.097926923 | 0.000151 | 0.000525144 |
HNSC | -1.742054768 | -2.801171047 | 1.059116279 | 2.31E-05 | 0.000120592 |
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TissGene-miRNA for CDH6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CDH6 |
TissGeneSNV for CDH6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S524L | SKCM | 8 |
p.E722K | SKCM | 6 |
p.G247E | SKCM | 3 |
p.P704S | SKCM | 2 |
p.D726N | SKCM | 2 |
p.E302K | SKCM | 2 |
p.R689Q | SKCM | 2 |
p.F60L | COAD | 2 |
p.D188N | SKCM | 2 |
p.D691N | SKCM | 2 |
p.E662K | SKCM | 2 |
p.K34N | SKCM | 1 |
p.D779V | SKCM | 1 |
p.R773Q | SKCM | 1 |
p.R226* | PCPG | 1 |
p.Q540H | HNSC | 1 |
p.L688V | UCEC | 1 |
p.D733N | STAD | 1 |
p.E230K | BLCA | 1 |
p.D759Y | LUAD | 1 |
p.L582P | STAD | 1 |
p.N545Y | SKCM | 1 |
p.S524L | UVM | 1 |
p.K467E | UCEC | 1 |
p.R448Q | SKCM | 1 |
p.T609M | BRCA | 1 |
p.V354G | ESCA | 1 |
p.D309Y | BLCA | 1 |
p.R115K | LIHC | 1 |
p.R653* | LUAD | 1 |
p.R429I | LUAD | 1 |
p.G310C | LUAD | 1 |
p.P356L | SKCM | 1 |
p.F208L | COAD | 1 |
p.E156* | LUAD | 1 |
p.S600T | LUAD | 1 |
p.K161E | LUAD | 1 |
p.V370A | SKCM | 1 |
p.P731S | HNSC | 1 |
p.P583L | SKCM | 1 |
p.T613M | PRAD | 1 |
p.T344A | COAD | 1 |
p.P772R | SKCM | 1 |
p.R229K | LUAD | 1 |
p.E326* | LUAD | 1 |
p.K339R | SKCM | 1 |
p.E375K | BLCA | 1 |
p.Y191F | LGG | 1 |
p.W770C | LUAD | 1 |
p.S443L | SKCM | 1 |
p.P704T | LUAD | 1 |
p.R137I | LUAD | 1 |
p.Y343F | STAD | 1 |
p.E105* | LUAD | 1 |
p.D434N | STAD | 1 |
p.S580T | LUAD | 1 |
p.R133K | SKCM | 1 |
p.L92F | SKCM | 1 |
p.D515N | SKCM | 1 |
p.S600Y | ACC | 1 |
p.T725K | HNSC | 1 |
p.R640Q | SKCM | 1 |
p.S44R | LUAD | 1 |
p.K341I | SKCM | 1 |
p.E119K | SKCM | 1 |
p.D409Y | LUAD | 1 |
p.S749F | SKCM | 1 |
p.E144K | SKCM | 1 |
p.F7C | BRCA | 1 |
p.D173N | HNSC | 1 |
p.R50C | STAD | 1 |
p.N351S | BRCA | 1 |
p.P583H | HNSC | 1 |
p.G243R | LUAD | 1 |
p.N351H | STAD | 1 |
p.D480Y | THYM | 1 |
p.V756L | HNSC | 1 |
p.L334F | SKCM | 1 |
p.G438D | SKCM | 1 |
p.R587Q | SKCM | 1 |
p.L697I | HNSC | 1 |
p.D70N | STAD | 1 |
p.P416S | SKCM | 1 |
p.K45T | ESCA | 1 |
p.D483N | SKCM | 1 |
p.A500T | SKCM | 1 |
p.R773* | HNSC | 1 |
p.Y353* | STAD | 1 |
p.P380A | LUAD | 1 |
p.R53K | SKCM | 1 |
p.Q507E | LUAD | 1 |
p.D314N | SKCM | 1 |
p.Q205E | LUAD | 1 |
p.Q322H | LUAD | 1 |
p.Y353X | STAD | 1 |
p.Y164* | BRCA | 1 |
p.T176A | SKCM | 1 |
p.A528T | PRAD | 1 |
p.L92I | UCEC | 1 |
p.S579C | LUSC | 1 |
p.R640Q | READ | 1 |
p.Y591C | CESC | 1 |
p.A500S | LUAD | 1 |
p.G582E | SKCM | 1 |
p.A349D | THCA | 1 |
p.R127* | SKCM | 1 |
p.P266S | SKCM | 1 |
p.D376Y | LUSC | 1 |
p.D515H | BLCA | 1 |
p.Q468R | LUAD | 1 |
p.T113P | KIRP | 1 |
p.L345F | SKCM | 1 |
p.R701Q | UCEC | 1 |
p.L636Q | LUAD | 1 |
p.S535* | BLCA | 1 |
p.V481I | LUAD | 1 |
p.E213K | HNSC | 1 |
p.T184M | PAAD | 1 |
p.V354G | STAD | 1 |
p.S526F | SKCM | 1 |
p.R689* | LGG | 1 |
p.E662G | OV | 1 |
p.E304Q | HNSC | 1 |
p.L527F | BLCA | 1 |
p.S439L | READ | 1 |
p.V139L | LUSC | 1 |
p.Y199X | STAD | 1 |
p.R423Q | STAD | 1 |
p.E741K | OV | 1 |
p.L258M | LUAD | 1 |
p.R773Q | LUAD | 1 |
p.R587W | BLCA | 1 |
p.R118K | SKCM | 1 |
p.D761Y | ESCA | 1 |
p.K52Q | SKCM | 1 |
p.Q81H | STAD | 1 |
p.K121E | LUAD | 1 |
p.G243S | OV | 1 |
p.R587Q | STAD | 1 |
p.V746M | BLCA | 1 |
p.G327E | SKCM | 1 |
p.D263N | SKCM | 1 |
p.D294N | BLCA | 1 |
p.Q391K | LUAD | 1 |
p.R638W | LIHC | 1 |
p.E490K | BLCA | 1 |
p.S439L | SKCM | 1 |
p.E741K | ESCA | 1 |
p.R689X | LGG | 1 |
p.V163D | SKCM | 1 |
p.T184M | COAD | 1 |
p.R707C | STAD | 1 |
p.D661N | SKCM | 1 |
p.A760E | LUAD | 1 |
p.T609M | CHOL | 1 |
p.G310S | COAD | 1 |
p.D263V | KIRC | 1 |
p.D574N | SKCM | 1 |
p.Q270K | LUAD | 1 |
p.A602T | COAD | 1 |
p.L445R | STAD | 1 |
p.G98E | SKCM | 1 |
p.Y199* | STAD | 1 |
p.H78R | MESO | 1 |
p.P283S | SKCM | 1 |
p.G42A | OV | 1 |
p.A602T | CESC | 1 |
p.M171I | LUAD | 1 |
p.A130D | KIRP | 1 |
p.R640Q | COAD | 1 |
p.P680S | SKCM | 1 |
p.A183V | THYM | 1 |
p.Q639K | LUAD | 1 |
p.D366N | SKCM | 1 |
p.P189S | SKCM | 1 |
p.S21L | SKCM | 1 |
p.R229S | ESCA | 1 |
p.P730S | SKCM | 1 |
p.P466S | PAAD | 1 |
p.R552P | SARC | 1 |
p.P265L | SKCM | 1 |
p.E603K | SKCM | 1 |
p.D661H | BLCA | 1 |
p.D661N | LUSC | 1 |
p.L359V | ESCA | 1 |
p.D691G | BLCA | 1 |
p.R357L | HNSC | 1 |
p.M427T | LIHC | 1 |
p.T546M | COAD | 1 |
p.Q129* | SKCM | 1 |
p.G548E | SKCM | 1 |
p.R701Q | BLCA | 1 |
p.S143F | SKCM | 1 |
p.G310D | SKCM | 1 |
p.S443L | COAD | 1 |
p.R689X | COAD | 1 |
p.P269S | SKCM | 1 |
p.P517A | BLCA | 1 |
p.V254A | STAD | 1 |
p.Q237K | LUAD | 1 |
p.S41C | PRAD | 1 |
p.R707C | SKCM | 1 |
p.S790C | LUAD | 1 |
p.D70Y | LUAD | 1 |
p.A547V | PRAD | 1 |
p.S526Y | READ | 1 |
p.D711N | LUAD | 1 |
p.R678G | LUAD | 1 |
p.L359F | SKCM | 1 |
p.K341T | PRAD | 1 |
p.R267Q | SKCM | 1 |
p.R448* | SKCM | 1 |
p.N155D | COAD | 1 |
p.I652S | UCEC | 1 |
p.P32Q | SKCM | 1 |
p.G94V | LUAD | 1 |
p.T190A | HNSC | 1 |
p.D154N | SKCM | 1 |
p.G86R | SKCM | 1 |
p.A128S | HNSC | 1 |
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TissGeneCNV for CDH6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CDH6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BLCA | TCGA-G2-A3VY-01A | NUP133-CDH6 | Out-of-frame | Chr1:229625702 | Chr5:31299571 |
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TissGeneNet for CDH6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CDH6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CDH6 |
TissGeneDrug for CDH6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CDH6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007134 | Renal Cell Carcinoma | 5 | BeFree |
umls:C1378703 | Renal carcinoma | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0006625 | Cachexia | 1 | CTD_human |
umls:C0027051 | Myocardial Infarction | 1 | BeFree,GAD |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1334603 | Malignant Mixed Mesodermal (Mullerian) Tumor | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |