TissGeneSummary for SLC17A4 |
Gene summary |
Basic gene information | Gene symbol | SLC17A4 |
Gene name | solute carrier family 17, member 4 | |
Synonyms | KAIA2138 | |
Cytomap | UCSC genome browser: 6p22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001286121.1, NM_005495.2, | |
Description | Na/PO4 cotransporterprobable small intestine urate exporterputative small intestine sodium-dependent phosphate transport proteinsolute carrier family 17 (sodium phosphate), member 4 | |
Modification date | 20141211 | |
dbXrefs | MIM : 604216 | |
HGNC : HGNC | ||
Ensembl : ENSG00000146039 | ||
HPRD : 05022 | ||
Vega : OTTHUMG00000014410 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC17A4 | |
BioGPS: 10050 | ||
Pathway | NCI Pathway Interaction Database: SLC17A4 | |
KEGG: SLC17A4 | ||
REACTOME: SLC17A4 | ||
Pathway Commons: SLC17A4 | ||
Context | iHOP: SLC17A4 | |
ligand binding site mutation search in PubMed: SLC17A4 | ||
UCL Cancer Institute: SLC17A4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADLIHC | |
Reference showing the relevant tissue of SLC17A4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC17A4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.288039828 | 1.057700172 | -3.34574 | 1.69E-07 | 7.45E-07 |
COAD | 3.115667864 | 6.862837095 | -3.747169231 | 1.92E-11 | 3.51E-10 |
KIRC | 6.253576838 | 2.423407394 | 3.830169444 | 3.42E-16 | 1.89E-15 |
ESCA | 1.964123808 | -2.091221647 | 4.055345455 | 0.00415 | 0.035093536 |
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TissGene-miRNA for SLC17A4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC17A4 |
TissGeneSNV for SLC17A4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K290N | STAD | 1 |
p.W488X | ESCA | 1 |
p.G280S | SKCM | 1 |
p.V388I | UCEC | 1 |
p.S391C | LUAD | 1 |
p.G448R | LUSC | 1 |
p.A204T | UCEC | 1 |
p.G4* | LUAD | 1 |
p.M64V | LGG | 1 |
p.P293Q | LUAD | 1 |
p.S206L | SKCM | 1 |
p.S472L | SKCM | 1 |
p.V22M | ESCA | 1 |
p.A483E | STAD | 1 |
p.P378S | SKCM | 1 |
p.S390Y | LUSC | 1 |
p.V11L | LUAD | 1 |
p.I214N | LGG | 1 |
p.G133* | ESCA | 1 |
p.V415A | LGG | 1 |
p.C223F | THYM | 1 |
p.G172E | SKCM | 1 |
p.I405V | LUAD | 1 |
p.G236R | DLBC | 1 |
p.H257Y | SKCM | 1 |
p.F338L | THYM | 1 |
p.A404V | UCEC | 1 |
p.P107S | SKCM | 1 |
p.S49L | SKCM | 1 |
p.P284L | SKCM | 1 |
p.S300C | BLCA | 1 |
p.Y185S | LGG | 1 |
p.P194S | SKCM | 1 |
p.G448V | LUSC | 1 |
p.A421D | COAD | 1 |
p.R389G | STAD | 1 |
p.D253N | SKCM | 1 |
p.G237R | SKCM | 1 |
p.M55I | SKCM | 1 |
p.D13N | SKCM | 1 |
p.P444L | SKCM | 1 |
p.A413G | LUAD | 1 |
p.A313G | ESCA | 1 |
p.R389K | SKCM | 1 |
p.M55L | SKCM | 1 |
p.L350V | BLCA | 1 |
p.C344F | LIHC | 1 |
p.S402F | LUAD | 1 |
p.E95X | ESCA | 1 |
p.W89* | STAD | 1 |
p.I343M | LUAD | 1 |
p.R460I | READ | 1 |
p.G144V | SARC | 1 |
p.G149R | SKCM | 1 |
p.G4R | STAD | 1 |
p.W105* | SKCM | 1 |
p.V380M | UCEC | 1 |
p.L294F | LUAD | 1 |
p.G111E | SKCM | 1 |
p.A164P | STAD | 1 |
p.G374E | SKCM | 1 |
p.C27Y | UCEC | 1 |
p.M288I | UCEC | 1 |
p.L361I | LUAD | 1 |
p.A176V | UCEC | 1 |
p.L363H | LIHC | 1 |
p.C46F | STAD | 1 |
p.L114V | LUSC | 1 |
p.Q184E | KIRC | 1 |
p.P337L | ESCA | 1 |
p.P284S | THYM | 1 |
p.M55I | UCEC | 1 |
p.N326H | COAD | 1 |
p.F408L | READ | 1 |
p.P193H | SKCM | 1 |
p.C167Y | STAD | 1 |
p.S403F | CESC | 1 |
p.S321L | LUAD | 1 |
p.G172R | TGCT | 1 |
p.E304K | KIRP | 1 |
p.F494L | LUAD | 1 |
p.F96Y | SKCM | 1 |
p.S379F | ESCA | 1 |
p.F308C | COAD | 1 |
p.E91K | SKCM | 1 |
p.P193S | SKCM | 1 |
p.P284S | SKCM | 1 |
p.T365N | LUAD | 1 |
p.G18D | HNSC | 1 |
p.P229S | PAAD | 1 |
p.A40S | STAD | 1 |
p.M209I | LUAD | 1 |
p.R170G | LUAD | 1 |
p.A60T | ESCA | 1 |
p.G211W | LUAD | 1 |
p.R197K | SKCM | 1 |
p.C46S | STAD | 1 |
p.I226K | SARC | 1 |
p.V400E | LUAD | 1 |
p.T365I | SKCM | 1 |
p.C344S | LGG | 1 |
p.A124S | LUAD | 1 |
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TissGeneCNV for SLC17A4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC17A4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A09N-01A | HIST1H2AC-SLC17A4 | 3UTR-CDS | Chr6:26124977 | Chr6:25778154 |
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TissGeneNet for SLC17A4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC17A4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC17A4 |
TissGeneDrug for SLC17A4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC17A4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004153 | Atherosclerosis | 2 | BeFree,GAD |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | GWASCAT |