TissGeneSummary for DCDC1 |
Gene summary |
Basic gene information | Gene symbol | DCDC1 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCDC1 | |
BioGPS: 100506627 | ||
Pathway | NCI Pathway Interaction Database: DCDC1 | |
KEGG: DCDC1 | ||
REACTOME: DCDC1 | ||
Pathway Commons: DCDC1 | ||
Context | iHOP: DCDC1 | |
ligand binding site mutation search in PubMed: DCDC1 | ||
UCL Cancer Institute: DCDC1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of DCDC1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DCDC1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.630935417 | 0.912979837 | -1.543915254 | 7.59E-13 | 6.94E-12 |
BRCA | 0.390705603 | -0.659525976 | 1.050231579 | 8.34E-09 | 2.77E-08 |
KIRC | -0.317347541 | 1.017688571 | -1.335036111 | 2.71E-18 | 1.82E-17 |
KICH | -1.948303485 | 1.170968515 | -3.119272 | 9.13E-23 | 1.18E-20 |
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TissGene-miRNA for DCDC1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DCDC1 |
TissGeneSNV for DCDC1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P634S | SKCM | 2 |
p.S568L | SKCM | 2 |
p.E1121K | SKCM | 2 |
p.P246S | SKCM | 2 |
p.G985R | SKCM | 2 |
p.R1424C | SKCM | 2 |
p.R1107* | SKCM | 2 |
p.R296Q | UCEC | 2 |
p.D784N | SKCM | 2 |
p.E987K | SKCM | 2 |
p.S818C | LUAD | 2 |
p.K67T | COAD | 1 |
p.N1502S | PRAD | 1 |
p.E225K | SKCM | 1 |
p.M304I | LIHC | 1 |
p.T1739A | SKCM | 1 |
p.W888* | SKCM | 1 |
p.S1153* | LUAD | 1 |
p.G749R | SKCM | 1 |
p.S578F | SKCM | 1 |
p.H794N | BLCA | 1 |
p.N207Y | BLCA | 1 |
p.S14Y | UCEC | 1 |
p.L776V | HNSC | 1 |
p.R996G | LIHC | 1 |
p.E1201Q | HNSC | 1 |
p.P858S | SKCM | 1 |
p.V952F | LUAD | 1 |
p.K1656R | ESCA | 1 |
p.G675E | SKCM | 1 |
p.H1633Y | PAAD | 1 |
p.E316* | SKCM | 1 |
p.H724Y | HNSC | 1 |
p.P925H | LUAD | 1 |
p.S686N | SKCM | 1 |
p.R276Q | LUAD | 1 |
p.L289R | PAAD | 1 |
p.E1301* | ACC | 1 |
p.D115N | SKCM | 1 |
p.V1232L | LUAD | 1 |
p.L1338F | LUAD | 1 |
p.S1157I | TGCT | 1 |
p.G308E | SKCM | 1 |
p.R963Q | SKCM | 1 |
p.L282I | UCEC | 1 |
p.L593F | HNSC | 1 |
p.A730T | LUAD | 1 |
p.A731S | ESCA | 1 |
p.K1351N | BLCA | 1 |
p.N982K | LUAD | 1 |
p.V27L | LUAD | 1 |
p.M1392I | SKCM | 1 |
p.R1757L | LUAD | 1 |
p.E789K | SKCM | 1 |
p.M1195I | SKCM | 1 |
p.R1025S | LUAD | 1 |
p.G375* | ESCA | 1 |
p.T965M | ESCA | 1 |
p.R996K | SKCM | 1 |
p.P1065L | PAAD | 1 |
p.E1283K | SKCM | 1 |
p.L224F | COAD | 1 |
p.E1215Q | BLCA | 1 |
p.V577F | ESCA | 1 |
p.S861C | PCPG | 1 |
p.K729E | ESCA | 1 |
p.G220S | STAD | 1 |
p.P54T | KIRC | 1 |
p.S1014F | SKCM | 1 |
p.R1699C | SKCM | 1 |
p.P280H | LUAD | 1 |
p.M1727I | SKCM | 1 |
p.H1276N | LUAD | 1 |
p.S1642Y | LUAD | 1 |
p.Q1718* | SKCM | 1 |
p.E1096Q | LUAD | 1 |
p.R996G | LUAD | 1 |
p.K1687* | HNSC | 1 |
p.R214X | COAD | 1 |
p.Q814K | HNSC | 1 |
p.K1203* | STAD | 1 |
p.P193Q | KIRC | 1 |
p.T191A | LUSC | 1 |
p.L653F | SKCM | 1 |
p.M709I | SKCM | 1 |
p.G303S | BLCA | 1 |
p.S75Y | ESCA | 1 |
p.S151F | SKCM | 1 |
p.E558K | HNSC | 1 |
p.L1371F | PAAD | 1 |
p.E1028Q | BLCA | 1 |
p.P1115H | LUAD | 1 |
p.G821C | LUAD | 1 |
p.A602S | HNSC | 1 |
p.A1591S | ESCA | 1 |
p.A212T | STAD | 1 |
p.K1203N | SKCM | 1 |
p.P136T | LUAD | 1 |
p.D252G | LGG | 1 |
p.C325F | LUAD | 1 |
p.P1657L | LGG | 1 |
p.A212T | COAD | 1 |
p.D1053H | LUAD | 1 |
p.E1332K | SKCM | 1 |
p.Q170K | STAD | 1 |
p.W797* | SKCM | 1 |
p.K1393N | LUAD | 1 |
p.D307V | LUAD | 1 |
p.Y893* | LUAD | 1 |
p.E628K | SKCM | 1 |
p.K315I | SKCM | 1 |
p.T239M | COAD | 1 |
p.Y179X | THYM | 1 |
p.G1426E | SKCM | 1 |
p.G314L | LUAD | 1 |
p.V1607L | BLCA | 1 |
p.L282V | PRAD | 1 |
p.E854K | SKCM | 1 |
p.K533* | SARC | 1 |
p.C1309R | HNSC | 1 |
p.S294L | SKCM | 1 |
p.K924N | LUAD | 1 |
p.P1461T | LUAD | 1 |
p.D96H | LUAD | 1 |
p.E931* | KIRC | 1 |
p.R1510K | SKCM | 1 |
p.G182* | ESCA | 1 |
p.D1421V | LUAD | 1 |
p.K1282N | PRAD | 1 |
p.G240V | HNSC | 1 |
p.R1652L | LUAD | 1 |
p.F679I | SKCM | 1 |
p.A1754G | LIHC | 1 |
p.A147S | STAD | 1 |
p.H669R | PAAD | 1 |
p.T705S | LUAD | 1 |
p.I327V | BLCA | 1 |
p.M264I | LIHC | 1 |
p.I1653M | BLCA | 1 |
p.H1780D | LUAD | 1 |
p.L567F | SKCM | 1 |
p.T41N | UCEC | 1 |
p.P1503L | SKCM | 1 |
p.R276Q | SKCM | 1 |
p.A800P | LUAD | 1 |
p.A1556G | LUAD | 1 |
p.P270S | SKCM | 1 |
p.L1371S | STAD | 1 |
p.E1639Q | BLCA | 1 |
p.T239M | STAD | 1 |
p.P1647S | ESCA | 1 |
p.R1466S | LUAD | 1 |
p.R1725Q | SARC | 1 |
p.S816N | SKCM | 1 |
p.T185I | LUAD | 1 |
p.H309Q | LUAD | 1 |
p.P242H | LUAD | 1 |
p.P886S | SKCM | 1 |
p.Q15H | STAD | 1 |
p.G314* | LUAD | 1 |
p.E969* | ESCA | 1 |
p.Q1021K | LUAD | 1 |
p.V847I | LUAD | 1 |
p.P1343L | HNSC | 1 |
p.S542F | SKCM | 1 |
p.Q465E | MESO | 1 |
p.N1143H | LUAD | 1 |
p.E1625* | SARC | 1 |
p.Q1397H | ESCA | 1 |
p.N245D | SKCM | 1 |
p.D1099A | PAAD | 1 |
p.L1438F | SKCM | 1 |
p.Q155H | HNSC | 1 |
p.E1085* | LUAD | 1 |
p.P725S | SKCM | 1 |
p.Y583* | LUAD | 1 |
p.Q30H | COAD | 1 |
p.N1225S | SKCM | 1 |
p.H167N | KIRC | 1 |
p.L169R | STAD | 1 |
p.E1300D | ESCA | 1 |
p.Q787P | SARC | 1 |
p.E983K | SKCM | 1 |
p.H804N | HNSC | 1 |
p.R1699P | ESCA | 1 |
p.P917T | HNSC | 1 |
p.G314V | LUAD | 1 |
p.R851K | SKCM | 1 |
p.R1588* | LGG | 1 |
p.E316X | SKCM | 1 |
p.S1518F | LUAD | 1 |
p.P44S | READ | 1 |
p.R1391W | LGG | 1 |
p.R1757Q | SKCM | 1 |
p.L391R | ESCA | 1 |
p.A817S | STAD | 1 |
p.L199M | STAD | 1 |
p.W755* | SKCM | 1 |
p.E1137K | SKCM | 1 |
p.K249E | LUAD | 1 |
p.L1335Q | LUAD | 1 |
p.E884K | SARC | 1 |
p.P140L | BLCA | 1 |
p.E316K | UCEC | 1 |
p.S673F | SKCM | 1 |
p.R950T | LUAD | 1 |
p.T1630K | LIHC | 1 |
p.Q170E | BLCA | 1 |
p.K320R | STAD | 1 |
p.E1168Q | LUAD | 1 |
p.Y337H | UCEC | 1 |
p.S170Y | STAD | 1 |
p.Q1745K | MESO | 1 |
p.E998* | LUAD | 1 |
p.R1466G | LUAD | 1 |
p.G78V | LUAD | 1 |
p.P697L | SKCM | 1 |
p.E316* | HNSC | 1 |
p.G182X | ESCA | 1 |
p.L1132I | LUAD | 1 |
p.P1550Q | LUAD | 1 |
p.Q1718H | PRAD | 1 |
p.A1448V | PAAD | 1 |
p.T872S | LUAD | 1 |
p.L1106H | LUAD | 1 |
p.P1716Q | SKCM | 1 |
p.E310G | LUAD | 1 |
p.K1601M | ESCA | 1 |
p.W1211* | BLCA | 1 |
p.L114V | ESCA | 1 |
p.H84D | HNSC | 1 |
p.G1432R | SKCM | 1 |
p.L254M | LUAD | 1 |
p.R1210C | HNSC | 1 |
p.R276L | LUSC | 1 |
p.A1591T | THYM | 1 |
p.G1422W | LUAD | 1 |
p.W1263C | LUAD | 1 |
p.M286I | SKCM | 1 |
p.N1509K | LUAD | 1 |
p.S735* | LUAD | 1 |
p.W1211C | BLCA | 1 |
p.S125F | LUSC | 1 |
p.M264I | SKCM | 1 |
p.Q468K | ESCA | 1 |
p.R1170* | LUAD | 1 |
p.K153R | UCEC | 1 |
p.G795S | SKCM | 1 |
p.K1282N | KIRC | 1 |
p.F300V | UCEC | 1 |
p.D307N | SKCM | 1 |
p.A212T | UCEC | 1 |
p.K1701Q | BLCA | 1 |
p.A24P | OV | 1 |
p.Q573P | SKCM | 1 |
p.G1734E | SKCM | 1 |
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TissGeneCNV for DCDC1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DCDC1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for DCDC1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DCDC1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DCDC1 |
TissGeneDrug for DCDC1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DCDC1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |