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| TissGeneSummary for XKR3 |
 Gene summary |
| Basic gene information | Gene symbol | XKR3 |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_XKR3 | |
| BioGPS: 100996296 | ||
| Pathway | NCI Pathway Interaction Database: XKR3 | |
| KEGG: XKR3 | ||
| REACTOME: XKR3 | ||
| Pathway Commons: XKR3 | ||
| Context | iHOP: XKR3 | |
| ligand binding site mutation search in PubMed: XKR3 | ||
| UCL Cancer Institute: XKR3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of XKR3 | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for XKR3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 0.31236817 | -1.74294433 | 2.0553125 | 3.17E-07 | 1.77E-06 |
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| TissGene-miRNA for XKR3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for XKR3 |
| TissGeneSNV for XKR3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R190Q | SKCM | 2 |
| p.R59Q | COAD | 2 |
| p.L114F | STAD | 1 |
| p.R94K | SKCM | 1 |
| p.E295X | PAAD | 1 |
| p.S167L | BLCA | 1 |
| p.I84T | PAAD | 1 |
| p.W322* | SKCM | 1 |
| p.W192* | PAAD | 1 |
| p.W192* | SKCM | 1 |
| p.E21K | SKCM | 1 |
| p.M183T | OV | 1 |
| p.S349N | UCEC | 1 |
| p.M1I | SKCM | 1 |
| p.W102X | SKCM | 1 |
| p.G15E | SKCM | 1 |
| p.L25F | SKCM | 1 |
| p.S19L | SKCM | 1 |
| p.T13K | HNSC | 1 |
| p.R154L | LGG | 1 |
| p.E191* | UCEC | 1 |
| p.E2* | LUSC | 1 |
| p.E56K | SKCM | 1 |
| p.N126S | SKCM | 1 |
| p.I219T | OV | 1 |
| p.S175F | SKCM | 1 |
| p.R59Q | SKCM | 1 |
| p.A324E | STAD | 1 |
| p.A78V | PRAD | 1 |
| p.R438S | HNSC | 1 |
| p.E10K | SKCM | 1 |
| p.I185M | BLCA | 1 |
| p.F39L | DLBC | 1 |
| p.E295* | PAAD | 1 |
| p.R94T | CESC | 1 |
| p.E7K | SKCM | 1 |
| p.W322X | SKCM | 1 |
| p.M358I | SKCM | 1 |
| p.F243S | HNSC | 1 |
| p.D332N | LUSC | 1 |
| p.G14E | SKCM | 1 |
| p.L43F | SKCM | 1 |
| p.E295* | UCEC | 1 |
| p.W102* | SKCM | 1 |
| p.S40* | HNSC | 1 |
| p.P34H | BRCA | 1 |
| p.K229R | SKCM | 1 |
| p.C321F | LUAD | 1 |
| p.D155N | SKCM | 1 |
| p.Q135E | LUAD | 1 |
| p.F73V | SKCM | 1 |
| p.I75V | PRAD | 1 |
| p.S32R | LUAD | 1 |
| p.R147K | SKCM | 1 |
| p.A254S | BLCA | 1 |
| p.I189T | LUAD | 1 |
| p.P34S | LUSC | 1 |
| p.W192X | PAAD | 1 |
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| TissGeneCNV for XKR3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for XKR3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF211581 | NUP214-XKR3 | chr9:134074402 | chr22:17288733 | |
| TCGAfusionPortal | PRADA | OV | TCGA-36-1571-01A | EXOC1-XKR3 | CDS-5UTR | Chr4:56737399 | Chr22:17288973 |
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| TissGeneNet for XKR3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| COAD (tumor) | COAD (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| KICH (tumor) | KICH (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| STAD (tumor) | STAD (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| THCA (tumor) | THCA (normal) |
| XKR3, CSNK2A1 (tumor) | XKR3, CSNK2A1 (normal) |
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| TissGeneProg for XKR3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for XKR3 |
| TissGeneDrug for XKR3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for XKR3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0153594 | Malignant neoplasm of testis | 4 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0008780 | Ciliary Motility Disorders | 1 | BeFree |
| umls:C0022521 | Kartagener Syndrome | 1 | BeFree |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C1274282 | Acral pseudolymphomatous angiokeratoma of children (APACHE) | 1 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1864873 | Testicular Microlithiasis | 1 | BeFree |
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