TissGeneSummary for FBXW10 |
Gene summary |
Basic gene information | Gene symbol | FBXW10 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FBXW10 | |
BioGPS: 100996906 | ||
Pathway | NCI Pathway Interaction Database: FBXW10 | |
KEGG: FBXW10 | ||
REACTOME: FBXW10 | ||
Pathway Commons: FBXW10 | ||
Context | iHOP: FBXW10 | |
ligand binding site mutation search in PubMed: FBXW10 | ||
UCL Cancer Institute: FBXW10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FBXW10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FBXW10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.265215364 | 1.899647348 | -2.164862712 | 2.56E-19 | 8.21E-18 |
LIHC | 0.774059314 | -0.772538686 | 1.546598 | 0.000113 | 0.000386112 |
COAD | -0.561936224 | -1.677774686 | 1.115838462 | 9.61E-05 | 0.000352099 |
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TissGene-miRNA for FBXW10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FBXW10 |
TissGeneSNV for FBXW10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G245A | UCEC | 6 |
p.T983A | PCPG | 4 |
p.D253N | SKCM | 3 |
p.T983A | UVM | 2 |
p.G603E | SKCM | 1 |
p.A1052T | SKCM | 1 |
p.P918T | KIRC | 1 |
p.K374N | OV | 1 |
p.S286P | LIHC | 1 |
p.L303F | PAAD | 1 |
p.E423Q | CESC | 1 |
p.V1018A | UVM | 1 |
p.L716I | UCEC | 1 |
p.R91Q | LUSC | 1 |
p.N641I | SKCM | 1 |
p.R518* | LUSC | 1 |
p.N407D | TGCT | 1 |
p.R607C | COAD | 1 |
p.S186G | UCEC | 1 |
p.G798E | SKCM | 1 |
p.G359W | SKCM | 1 |
p.L170F | PRAD | 1 |
p.T695P | THYM | 1 |
p.P775S | SKCM | 1 |
p.R553* | UCEC | 1 |
p.S882I | UCEC | 1 |
p.G604E | BLCA | 1 |
p.S180F | SKCM | 1 |
p.V577A | PAAD | 1 |
p.G1038S | LUAD | 1 |
p.T381I | UCEC | 1 |
p.Q142H | LUSC | 1 |
p.Q822X | COAD | 1 |
p.W306* | LGG | 1 |
p.P726T | UCEC | 1 |
p.S6L | STAD | 1 |
p.R518Q | STAD | 1 |
p.T137I | LUSC | 1 |
p.A190V | GBM | 1 |
p.G632E | SKCM | 1 |
p.N407D | BLCA | 1 |
p.N407D | HNSC | 1 |
p.K1000N | BLCA | 1 |
p.E387K | SKCM | 1 |
p.E163K | SKCM | 1 |
p.E465D | PAAD | 1 |
p.K505E | UCEC | 1 |
p.E998K | SKCM | 1 |
p.T674I | LUAD | 1 |
p.I917V | LUSC | 1 |
p.L258S | HNSC | 1 |
p.A631T | STAD | 1 |
p.V538L | SKCM | 1 |
p.S622F | SKCM | 1 |
p.N407D | UCEC | 1 |
p.D649N | UCEC | 1 |
p.L800M | ESCA | 1 |
p.R532T | BRCA | 1 |
p.P644L | SKCM | 1 |
p.E735K | SKCM | 1 |
p.A824V | COAD | 1 |
p.N407D | LUAD | 1 |
p.P746S | SKCM | 1 |
p.P380S | SKCM | 1 |
p.N670I | SKCM | 1 |
p.L261V | COAD | 1 |
p.V1018A | STAD | 1 |
p.T724M | PAAD | 1 |
p.I23N | COAD | 1 |
p.L258* | KIRP | 1 |
p.D253N | LIHC | 1 |
p.S651F | SKCM | 1 |
p.E416K | SKCM | 1 |
p.N710D | UCEC | 1 |
p.R15C | SKCM | 1 |
p.G245A | ESCA | 1 |
p.Y288C | STAD | 1 |
p.D357H | UCEC | 1 |
p.R363C | COAD | 1 |
p.D620N | UCEC | 1 |
p.Q53H | BLCA | 1 |
p.L257V | BLCA | 1 |
p.F867L | CESC | 1 |
p.K756R | BRCA | 1 |
p.K802N | STAD | 1 |
p.Q81P | PAAD | 1 |
p.H366N | LIHC | 1 |
p.T695M | STAD | 1 |
p.G575E | BLCA | 1 |
p.D634Y | UCEC | 1 |
p.P909T | KIRC | 1 |
p.L831R | LUAD | 1 |
p.L258X | KIRP | 1 |
p.V1018A | PCPG | 1 |
p.N407S | SKCM | 1 |
p.A1043T | SKCM | 1 |
p.L497F | SKCM | 1 |
p.R776Q | HNSC | 1 |
p.I174F | PRAD | 1 |
p.Q787E | BRCA | 1 |
p.G525E | SKCM | 1 |
p.T703I | LUAD | 1 |
p.E765K | SKCM | 1 |
p.A631P | READ | 1 |
p.Q78H | CESC | 1 |
p.F757L | UCEC | 1 |
p.N343T | UCEC | 1 |
p.V1022A | LUSC | 1 |
p.L800* | TGCT | 1 |
p.E1007K | SKCM | 1 |
p.V1017A | BRCA | 1 |
p.S814Y | LGG | 1 |
p.M680T | STAD | 1 |
p.D184N | UCEC | 1 |
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TissGeneCNV for FBXW10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FBXW10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FBXW10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FBXW10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FBXW10 |
TissGeneDrug for FBXW10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FBXW10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011991 | Diarrhea | 1 | BeFree |
umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |