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TissGeneSummary for TSPAN1 |
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Basic gene information | Gene symbol | TSPAN1 |
Gene name | tetraspanin 1 | |
Synonyms | NET1|TM4C|TM4SF | |
Cytomap | UCSC genome browser: 1p34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_005727.3, | |
Description | tetraspan 1tetraspanin-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 613170 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117472 | ||
HPRD : 18232 | ||
Vega : OTTHUMG00000007602 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TSPAN1 | |
BioGPS: 10103 | ||
Pathway | NCI Pathway Interaction Database: TSPAN1 | |
KEGG: TSPAN1 | ||
REACTOME: TSPAN1 | ||
Pathway Commons: TSPAN1 | ||
Context | iHOP: TSPAN1 | |
ligand binding site mutation search in PubMed: TSPAN1 | ||
UCL Cancer Institute: TSPAN1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
Reference showing the relevant tissue of TSPAN1 | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0008283 | cell proliferation | 22378020 | GO:0050821 | protein stabilization | 21836059 | GO:0071934 | thiamine transmembrane transport | 21836059 | GO:0008283 | cell proliferation | 22378020 | GO:0050821 | protein stabilization | 21836059 | GO:0071934 | thiamine transmembrane transport | 21836059 |
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TissGeneExp for TSPAN1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 3.559515967 | 6.027758275 | -2.468242308 | 4.45E-11 | 7.07E-10 |
PRAD | 5.669960198 | 4.249594813 | 1.420365385 | 2.53E-11 | 7.00E-10 |
KIRC | 2.445034984 | 4.018025262 | -1.572990278 | 1.18E-08 | 3.56E-08 |
BRCA | 1.002414078 | -0.685373642 | 1.687787719 | 3.02E-10 | 1.14E-09 |
KICH | 1.391334428 | 3.932562428 | -2.541228 | 1.91E-09 | 1.14E-08 |
LUSC | 0.571921095 | 1.597142664 | -1.025221569 | 0.00425 | 0.007190834 |
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TissGene-miRNA for TSPAN1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TSPAN1 |
TissGeneSNV for TSPAN1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G74R | ESCA | 1 |
p.I126M | BRCA | 1 |
p.L240V | BLCA | 1 |
p.M11V | KIRC | 1 |
p.G146W | UCEC | 1 |
p.V218A | SKCM | 1 |
p.V66A | LUSC | 1 |
p.T119A | BLCA | 1 |
p.T119M | COAD | 1 |
p.D35N | LUAD | 1 |
p.E226K | SKCM | 1 |
p.P171L | LGG | 1 |
p.Y130H | STAD | 1 |
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TissGeneCNV for TSPAN1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TSPAN1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | PRAD | TCGA-G9-6371-01A | TSPAN1-USP20 | 3UTR-CDS | Chr1:46651630 | Chr9:132620746 |
TCGAfusionPortal | PRADA | PRAD | TCGA-HC-7738-01A | TSPAN1-TFF3 | 3UTR-5UTR | Chr1:46651630 | Chr21:43735706 |
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TissGeneNet for TSPAN1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TSPAN1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TSPAN1 |
TissGeneDrug for TSPAN1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TSPAN1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
umls:C0699791 | Stomach Carcinoma | 5 | BeFree |
umls:C2239176 | Liver carcinoma | 5 | BeFree,LHGDN |
umls:C0001418 | Adenocarcinoma | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
umls:C0278701 | Gastric Adenocarcinoma | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 4 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,LHGDN |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0011436 | Dentinogenesis Imperfecta | 2 | BeFree |
umls:C0553723 | Squamous cell carcinoma of skin | 2 | BeFree |
umls:C1261473 | Sarcoma | 2 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0007873 | Uterine Cervical Neoplasm | 1 | LHGDN |
umls:C0011311 | Dengue Fever | 1 | BeFree |
umls:C0011430 | Dentin Dysplasia | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0029121 | Oppositional Defiant Disorder | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |