TissGeneSummary for MAGEA12 |
Gene summary |
Basic gene information | Gene symbol | MAGEA12 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEA12 | |
BioGPS: 101060230 | ||
Pathway | NCI Pathway Interaction Database: MAGEA12 | |
KEGG: MAGEA12 | ||
REACTOME: MAGEA12 | ||
Pathway Commons: MAGEA12 | ||
Context | iHOP: MAGEA12 | |
ligand binding site mutation search in PubMed: MAGEA12 | ||
UCL Cancer Institute: MAGEA12 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
Reference showing the relevant tissue of MAGEA12 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for MAGEA12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.131105327 | -2.053114281 | 2.184219608 | 3.34E-05 | 7.23E-05 |
LIHC | 0.587070699 | -2.235947301 | 2.823018 | 3.97E-06 | 1.87E-05 |
STAD | -0.978041426 | -2.525678926 | 1.5476375 | 0.00487 | 0.018851343 |
LUAD | -0.459978818 | -2.305965025 | 1.845986207 | 0.000155 | 0.000379962 |
HNSC | 0.605192513 | -2.041105161 | 2.646297674 | 8.02E-05 | 0.000367515 |
Top |
TissGene-miRNA for MAGEA12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for MAGEA12 |
TissGeneSNV for MAGEA12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F130V | CESC | 3 |
p.E90Q | CESC | 3 |
p.L109I | CESC | 3 |
p.V107A | CESC | 3 |
p.A114V | CESC | 3 |
p.G20R | SKCM | 3 |
p.S300F | SKCM | 2 |
p.R125* | SKCM | 2 |
p.R125Q | SKCM | 2 |
p.R125X | SKCM | 2 |
p.T247I | CESC | 2 |
p.I140L | CESC | 2 |
p.G296E | CESC | 2 |
p.S81R | CESC | 2 |
p.Q19R | CESC | 2 |
p.A108P | LUAD | 1 |
p.P65T | COAD | 1 |
p.P242H | UCEC | 1 |
p.N76K | UCEC | 1 |
p.R171S | LIHC | 1 |
p.L120V | HNSC | 1 |
p.K123T | ESCA | 1 |
p.E52D | LUSC | 1 |
p.F143C | ACC | 1 |
p.V166A | STAD | 1 |
p.S87P | LUAD | 1 |
p.P303H | LUAD | 1 |
p.H9Q | UCEC | 1 |
p.S43A | LUAD | 1 |
p.P62L | SKCM | 1 |
p.P31S | SKCM | 1 |
p.D192E | LGG | 1 |
p.D265N | SKCM | 1 |
p.E235K | UCEC | 1 |
p.L291V | LUAD | 1 |
p.E37Q | CESC | 1 |
p.R51Q | BLCA | 1 |
p.S294G | CESC | 1 |
p.D214N | CESC | 1 |
p.P275S | SKCM | 1 |
p.S69F | BLCA | 1 |
p.P59L | LUSC | 1 |
p.I209V | STAD | 1 |
p.E235K | SKCM | 1 |
p.P217S | SKCM | 1 |
p.E91Q | BRCA | 1 |
p.T247M | LUAD | 1 |
p.P266S | STAD | 1 |
p.G94V | GBM | 1 |
p.Q248H | COAD | 1 |
p.R171H | COAD | 1 |
p.F130I | HNSC | 1 |
p.Q19R | HNSC | 1 |
p.E314Q | HNSC | 1 |
p.Y269* | LUAD | 1 |
p.D214N | SKCM | 1 |
p.V139I | LUAD | 1 |
p.D84N | SKCM | 1 |
p.G137E | CESC | 1 |
p.F239I | STAD | 1 |
p.V117I | SKCM | 1 |
p.K292R | BLCA | 1 |
p.P217H | BRCA | 1 |
p.E313K | SKCM | 1 |
p.G263C | LUAD | 1 |
p.T247I | LUAD | 1 |
p.P129Q | LUAD | 1 |
p.D187N | SKCM | 1 |
p.K198* | BRCA | 1 |
p.P61S | SKCM | 1 |
p.G183V | LUSC | 1 |
p.G67V | LUAD | 1 |
p.E253K | SKCM | 1 |
p.E128K | BRCA | 1 |
p.K198N | GBM | 1 |
p.Q92E | CESC | 1 |
p.I221M | BRCA | 1 |
p.L250F | BLCA | 1 |
p.K123N | LUAD | 1 |
p.F143C | CESC | 1 |
p.G20V | SKCM | 1 |
p.E90K | SKCM | 1 |
p.R259Q | COAD | 1 |
Top |
TissGeneCNV for MAGEA12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for MAGEA12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for MAGEA12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for MAGEA12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for MAGEA12 |
TissGeneDrug for MAGEA12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for MAGEA12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | LHGDN |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |