TissGeneSummary for SGK2 |
Gene summary |
Basic gene information | Gene symbol | SGK2 |
Gene name | serum/glucocorticoid regulated kinase 2 | |
Synonyms | H-SGK2|dJ138B7.2 | |
Cytomap | UCSC genome browser: 20q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001199264.1, NM_016276.3,NM_170693.2, | |
Description | serine/threonine-protein kinase Sgk2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607589 | |
HGNC : HGNC | ||
Ensembl : ENSG00000101049 | ||
HPRD : 06348 | ||
Vega : OTTHUMG00000033054 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SGK2 | |
BioGPS: 10110 | ||
Pathway | NCI Pathway Interaction Database: SGK2 | |
KEGG: SGK2 | ||
REACTOME: SGK2 | ||
Pathway Commons: SGK2 | ||
Context | iHOP: SGK2 | |
ligand binding site mutation search in PubMed: SGK2 | ||
UCL Cancer Institute: SGK2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of SGK2 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SGK2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.455629779 | -2.93252633 | 1.476896552 | 1.64E-07 | 6.20E-07 |
KIRC | 2.058583679 | 4.343790624 | -2.285206944 | 2.51E-31 | 5.41E-30 |
KIRP | 3.46006979 | 4.645710415 | -1.185640625 | 6.65E-07 | 3.52E-06 |
BRCA | -2.400320341 | 1.252683167 | -3.653003509 | 9.33E-38 | 2.26E-36 |
COAD | 2.035878444 | 4.382897675 | -2.347019231 | 2.15E-06 | 1.13E-05 |
HNSC | -3.769081663 | -2.378000268 | -1.391081395 | 0.00182 | 0.00569541 |
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TissGene-miRNA for SGK2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SGK2 |
TissGeneSNV for SGK2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M61I | SKCM | 2 |
p.A146P | KIRC | 1 |
p.F138L | KIRP | 1 |
p.D359G | HNSC | 1 |
p.R336Q | BLCA | 1 |
p.A282V | LUSC | 1 |
p.E142K | BLCA | 1 |
p.L48F | SKCM | 1 |
p.S63P | BRCA | 1 |
p.F352L | HNSC | 1 |
p.S356F | SKCM | 1 |
p.K124N | LUSC | 1 |
p.P49S | KIRC | 1 |
p.P88L | HNSC | 1 |
p.S145G | KIRP | 1 |
p.P49L | ESCA | 1 |
p.E53K | SKCM | 1 |
p.F138L | SKCM | 1 |
p.C17S | LUAD | 1 |
p.G23R | LIHC | 1 |
p.R144C | STAD | 1 |
p.R213* | SKCM | 1 |
p.M1I | SKCM | 1 |
p.L266F | UCS | 1 |
p.Q273E | LGG | 1 |
p.R189H | LUAD | 1 |
p.S102F | SKCM | 1 |
p.G83R | LIHC | 1 |
p.L206F | UCS | 1 |
p.P376H | UCEC | 1 |
p.R92W | COAD | 1 |
p.D342Y | UCEC | 1 |
p.D299G | HNSC | 1 |
p.R276Q | BLCA | 1 |
p.S409L | STAD | 1 |
p.E223D | READ | 1 |
p.G178R | KIRC | 1 |
p.I295M | KIRP | 1 |
p.S63C | BRCA | 1 |
p.R336W | STAD | 1 |
p.P270H | UCEC | 1 |
p.P28L | HNSC | 1 |
p.A206P | KIRC | 1 |
p.D361N | LUAD | 1 |
p.E163K | SKCM | 1 |
p.R84C | STAD | 1 |
p.M33I | BRCA | 1 |
p.L50P | COAD | 1 |
p.F198L | KIRP | 1 |
p.G83W | LUSC | 1 |
p.S25L | BLCA | 1 |
p.W217R | LUAD | 1 |
p.A418V | CHOL | 1 |
p.G44E | SKCM | 1 |
p.R129H | LUAD | 1 |
p.A59T | SKCM | 1 |
p.E76Q | BLCA | 1 |
p.G315R | BRCA | 1 |
p.E136Q | BLCA | 1 |
p.G315V | LUAD | 1 |
p.K149T | CESC | 1 |
p.C169* | HNSC | 1 |
p.E285Q | HNSC | 1 |
p.R127Q | SKCM | 1 |
p.I355M | KIRP | 1 |
p.W278L | STAD | 1 |
p.G119E | SKCM | 1 |
p.P11S | LGG | 1 |
p.P307S | SKCM | 1 |
p.R137K | HNSC | 1 |
p.P194S | DLBC | 1 |
p.R189H | KIRP | 1 |
p.R54H | COAD | 1 |
p.L166F | SKCM | 1 |
p.F412L | HNSC | 1 |
p.S293I | SARC | 1 |
p.P316H | LGG | 1 |
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TissGeneCNV for SGK2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SGK2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-AA7B-01A | TSHZ2-SGK2 | Out-of-Frame | chr20:51589872 | chr20:42198024 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-AA7B-01A | TSHZ2-SGK2 | Out-of-Frame | chr20:51589872 | chr20:42199256 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1IN-01A | FAM53B-SGK2 | In-frame | Chr10:126370176 | Chr20:42198025 |
TCGAfusionPortal | PRADA | LUAD | TCGA-75-5146-01A | NCOA3-SGK2 | 5UTR-5UTR | Chr20:46212005 | Chr20:42195113 |
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TissGeneNet for SGK2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SGK2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SGK2 |
TissGeneDrug for SGK2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SGK2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |