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| TissGeneSummary for CELA3A |
 Gene summary |
| Basic gene information | Gene symbol | CELA3A |
| Gene name | chymotrypsin-like elastase family, member 3A | |
| Synonyms | ELA3|ELA3A | |
| Cytomap | UCSC genome browser: 1p36.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005747.4, | |
| Description | chymotrypsin-like elastase family member 3Aelastase 1elastase 3A, pancreaticelastase IIIAelastase-3Aprotease E | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000142789 | ||
| HPRD : 06497 | ||
| Vega : OTTHUMG00000002755 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CELA3A | |
| BioGPS: 10136 | ||
| Pathway | NCI Pathway Interaction Database: CELA3A | |
| KEGG: CELA3A | ||
| REACTOME: CELA3A | ||
| Pathway Commons: CELA3A | ||
| Context | iHOP: CELA3A | |
| ligand binding site mutation search in PubMed: CELA3A | ||
| UCL Cancer Institute: CELA3A | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of CELA3A | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CELA3A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| ESCA | -1.916410761 | 1.664025603 | -3.580436364 | 0.00448 | 0.037039108 |
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| TissGene-miRNA for CELA3A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CELA3A |
| TissGeneSNV for CELA3A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R210H | PAAD | 2 |
| p.R28C | STAD | 1 |
| p.G72D | UCEC | 1 |
| p.P96L | SKCM | 1 |
| p.W230L | LUAD | 1 |
| p.L180V | ESCA | 1 |
| p.L11F | SKCM | 1 |
| p.S8F | SKCM | 1 |
| p.S23F | STAD | 1 |
| p.I102M | HNSC | 1 |
| p.A15D | UCEC | 1 |
| p.I209V | SKCM | 1 |
| p.G72C | LUAD | 1 |
| p.R210C | COAD | 1 |
| p.R179Q | THYM | 1 |
| p.E87K | BRCA | 1 |
| p.S116L | HNSC | 1 |
| p.R28L | LUAD | 1 |
| p.G195V | LUAD | 1 |
| p.Q43* | CESC | 1 |
| p.V239F | HNSC | 1 |
| p.S257Y | LUAD | 1 |
| p.A125T | READ | 1 |
| p.V139I | READ | 1 |
| p.N89D | KIRP | 1 |
| p.Y166C | BLCA | 1 |
| p.E105G | LIHC | 1 |
| p.D227Y | THYM | 1 |
| p.D261G | KIRC | 1 |
| p.G148S | LUAD | 1 |
| p.D78N | SKCM | 1 |
| p.H24R | SKCM | 1 |
| p.R4W | UCEC | 1 |
| p.I247T | LIHC | 1 |
| p.T236I | MESO | 1 |
| p.L151I | UCEC | 1 |
| p.A125S | SARC | 1 |
| p.E106D | LIHC | 1 |
| p.S25P | SKCM | 1 |
| p.D227G | UCEC | 1 |
| p.A64V | HNSC | 1 |
| p.D227G | HNSC | 1 |
| p.S116L | SKCM | 1 |
| p.A35V | PAAD | 1 |
| p.S16L | CESC | 1 |
| p.R255G | BLCA | 1 |
| p.T251P | UCEC | 1 |
| p.A142T | LGG | 1 |
| p.V14I | DLBC | 1 |
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| TissGeneCNV for CELA3A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CELA3A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | COAD | TCGA-G4-6588-01A | CDC42-CELA3A | 5'UTR-CDS | chr1:22379235 | chr1:22331939 |
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| TissGeneNet for CELA3A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CELA3A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CELA3A |
| TissGeneDrug for CELA3A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CELA3A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010674 | Cystic Fibrosis | 2 | BeFree |
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