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| TissGeneSummary for PDZK1IP1 |
 Gene summary |
| Basic gene information | Gene symbol | PDZK1IP1 |
| Gene name | PDZK1 interacting protein 1 | |
| Synonyms | DD96|MAP17|SPAP | |
| Cytomap | UCSC genome browser: 1p33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005764.3, | |
| Description | 17 kDa membrane-associated proteinPDZK1-interacting protein 1epithelial protein up-regulated in carcinoma, membrane associated protein 17membrane-associated protein 17 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607178 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000162366 | ||
| HPRD : 06211 | ||
| Vega : OTTHUMG00000007852 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PDZK1IP1 | |
| BioGPS: 10158 | ||
| Pathway | NCI Pathway Interaction Database: PDZK1IP1 | |
| KEGG: PDZK1IP1 | ||
| REACTOME: PDZK1IP1 | ||
| Pathway Commons: PDZK1IP1 | ||
| Context | iHOP: PDZK1IP1 | |
| ligand binding site mutation search in PubMed: PDZK1IP1 | ||
| UCL Cancer Institute: PDZK1IP1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of PDZK1IP1 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PDZK1IP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -4.034452805 | 3.376371195 | -7.410824 | 5.74E-15 | 1.17E-13 |
| THCA | 0.171676347 | -3.307123653 | 3.4788 | 1.75E-10 | 1.13E-09 |
| STAD | 2.384489695 | 0.57418657 | 1.810303125 | 0.016 | 0.049360768 |
| LIHC | -0.074916805 | -1.669954805 | 1.595038 | 0.00714 | 0.015700931 |
| HNSC | 1.913348125 | 3.071243474 | -1.157895349 | 0.00397 | 0.011068773 |
| LUSC | 0.06041543 | 1.397635038 | -1.337219608 | 0.00011 | 0.000226228 |
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| TissGene-miRNA for PDZK1IP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-27a-3p | MIMAT0000084 | 0.007 | -0.36 | 56 |
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| TissGeneMut for PDZK1IP1 |
| TissGeneSNV for PDZK1IP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G69E | SKCM | 2 |
| p.E60K | SKCM | 1 |
| p.C55X | ESCA | 1 |
| p.S85L | STAD | 1 |
| p.M64I | SKCM | 1 |
| p.V77A | BRCA | 1 |
| p.V44I | COAD | 1 |
| p.A14T | SKCM | 1 |
| p.G74E | SKCM | 1 |
| p.S85L | SKCM | 1 |
| p.C55F | LUAD | 1 |
| p.S85L | BLCA | 1 |
| p.A87T | UCEC | 1 |
| p.E96X | LIHC | 1 |
| Top |
| TissGeneCNV for PDZK1IP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PDZK1IP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | U21049 | CDK13-PDZK1IP1 | chr7:39995933 | chr1:47649265 |
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| TissGeneNet for PDZK1IP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
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| THCA (tumor) | THCA (normal) |
| PDZK1IP1, COPS6, PDZK1, UTP14A (tumor) | PDZK1IP1, COPS6, PDZK1, UTP14A (normal) |
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| TissGeneProg for PDZK1IP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PDZK1IP1 |
| TissGeneDrug for PDZK1IP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PDZK1IP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011334 | Dental caries | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0333519 | Caries (morphologic abnormality) | 2 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0007873 | Uterine Cervical Neoplasm | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025500 | Mesothelioma | 1 | LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0850572 | Adenomatous polyp of colon | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
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