TissGeneSummary for ARAP2 |
Gene summary |
Basic gene information | Gene symbol | ARAP2 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARAP2 | |
BioGPS: 101928667 | ||
Pathway | NCI Pathway Interaction Database: ARAP2 | |
KEGG: ARAP2 | ||
REACTOME: ARAP2 | ||
Pathway Commons: ARAP2 | ||
Context | iHOP: ARAP2 | |
ligand binding site mutation search in PubMed: ARAP2 | ||
UCL Cancer Institute: ARAP2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | StomachThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STADTHCA | |
Reference showing the relevant tissue of ARAP2 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ARAP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.387384514 | -0.379402514 | -1.007982 | 1.23E-06 | 6.46E-06 |
LUAD | 0.237315831 | 1.466550313 | -1.229234483 | 2.87E-19 | 5.11E-18 |
THCA | 1.082746164 | 2.219876672 | -1.137130508 | 6.49E-18 | 1.50E-16 |
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TissGene-miRNA for ARAP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-130b-3p | MIMAT0000691 | 0.038 | -0.27 | 60 |
LUAD | hsa-miR-301a-3p | MIMAT0000688 | 0.038 | -0.27 | 60 |
UCS | hsa-miR-30c-5p | MIMAT0000244 | 0.039 | -0.28 | 56 |
ACC | hsa-miR-381-3p | MIMAT0000736 | 0.0053 | -0.32 | 78 |
ACC | hsa-miR-381-3p | MIMAT0000736 | 0.0053 | -0.32 | 78 |
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TissGeneMut for ARAP2 |
TissGeneSNV for ARAP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E197* | UCEC | 3 |
p.R280* | SKCM | 3 |
p.P653L | SKCM | 2 |
p.S243F | SKCM | 2 |
p.R1628Q | SKCM | 2 |
p.R642Q | SKCM | 2 |
p.I568V | HNSC | 1 |
p.S207T | HNSC | 1 |
p.R1624X | SKCM | 1 |
p.A1227T | SKCM | 1 |
p.I470V | STAD | 1 |
p.D381N | UCEC | 1 |
p.V275I | STAD | 1 |
p.R287Q | SKCM | 1 |
p.R57H | THYM | 1 |
p.E959Q | BLCA | 1 |
p.L1232F | SARC | 1 |
p.E695* | LUAD | 1 |
p.K1224N | OV | 1 |
p.Q1073* | LUAD | 1 |
p.S240L | STAD | 1 |
p.L20F | LUAD | 1 |
p.Y934H | LAML | 1 |
p.A1362V | STAD | 1 |
p.E251* | UCEC | 1 |
p.A818S | LUAD | 1 |
p.D1480G | STAD | 1 |
p.E978K | SKCM | 1 |
p.L362F | UCEC | 1 |
p.E662K | UCEC | 1 |
p.P653S | SKCM | 1 |
p.L1703F | SARC | 1 |
p.L68W | SKCM | 1 |
p.R1221I | UCEC | 1 |
p.F1138I | SARC | 1 |
p.R1221I | HNSC | 1 |
p.F1138C | UCEC | 1 |
p.F898V | COAD | 1 |
p.R1430W | LUSC | 1 |
p.Q1251K | ESCA | 1 |
p.T628S | GBM | 1 |
p.F1046C | COAD | 1 |
p.V465I | CESC | 1 |
p.A724T | UCEC | 1 |
p.R1608K | SKCM | 1 |
p.P159S | DLBC | 1 |
p.P1644S | SKCM | 1 |
p.E912D | UCEC | 1 |
p.Y1509C | STAD | 1 |
p.P1648S | SKCM | 1 |
p.F1377S | STAD | 1 |
p.R1171K | KIRC | 1 |
p.S575L | SKCM | 1 |
p.P333S | SARC | 1 |
p.S137I | UCEC | 1 |
p.Q501E | LUAD | 1 |
p.E695K | SKCM | 1 |
p.A815S | LUAD | 1 |
p.K602N | ESCA | 1 |
p.E811X | COAD | 1 |
p.C1146S | LUAD | 1 |
p.E354K | SKCM | 1 |
p.T893A | SKCM | 1 |
p.S424R | BRCA | 1 |
p.E1065* | LUAD | 1 |
p.P149A | LUAD | 1 |
p.R1551C | LUAD | 1 |
p.S218F | UCEC | 1 |
p.Q423* | BLCA | 1 |
p.V820A | STAD | 1 |
p.S511I | LUAD | 1 |
p.S90* | BLCA | 1 |
p.R57H | COAD | 1 |
p.Q1251H | BLCA | 1 |
p.E1538A | COAD | 1 |
p.L1693F | SKCM | 1 |
p.S1231F | SKCM | 1 |
p.S735F | SKCM | 1 |
p.E1548K | SKCM | 1 |
p.G984R | LUAD | 1 |
p.L1433V | LUAD | 1 |
p.G609I | LUAD | 1 |
p.P472L | SKCM | 1 |
p.E1445K | SKCM | 1 |
p.G335V | LUSC | 1 |
p.D1465N | SKCM | 1 |
p.R1346W | COAD | 1 |
p.K558T | SKCM | 1 |
p.S1404L | SKCM | 1 |
p.M1050I | SARC | 1 |
p.R427K | SKCM | 1 |
p.S279F | SKCM | 1 |
p.E1310X | READ | 1 |
p.D1217Y | BRCA | 1 |
p.R1624* | SKCM | 1 |
p.H189Q | COAD | 1 |
p.E784K | KIRC | 1 |
p.Q100* | ESCA | 1 |
p.N42S | ESCA | 1 |
p.G1434E | SKCM | 1 |
p.T849I | UCEC | 1 |
p.G1505E | SKCM | 1 |
p.R562K | SKCM | 1 |
p.I1553V | OV | 1 |
p.Q100X | ESCA | 1 |
p.Q1698L | LUAD | 1 |
p.R550I | PAAD | 1 |
p.K91* | LUAD | 1 |
p.P1156L | SKCM | 1 |
p.G797E | SKCM | 1 |
p.R597K | SKCM | 1 |
p.S582C | COAD | 1 |
p.R399* | SKCM | 1 |
p.E105* | UCEC | 1 |
p.E1008A | LUAD | 1 |
p.S530C | LUAD | 1 |
p.I1256M | SKCM | 1 |
p.A1421T | STAD | 1 |
p.D508Y | BLCA | 1 |
p.G858R | SKCM | 1 |
p.S272G | SKCM | 1 |
p.V275A | STAD | 1 |
p.E1599G | LIHC | 1 |
p.R1689W | KIRP | 1 |
p.G1112S | SKCM | 1 |
p.V392G | LUAD | 1 |
p.A1421T | LUAD | 1 |
p.D43Y | LUAD | 1 |
p.A985S | LUAD | 1 |
p.Q549P | UCEC | 1 |
p.A367T | BLCA | 1 |
p.E559* | UCEC | 1 |
p.E1393K | SKCM | 1 |
p.R1689W | KIRC | 1 |
p.R1626Q | THCA | 1 |
p.P1233S | SKCM | 1 |
p.N42K | ESCA | 1 |
p.E918X | ESCA | 1 |
p.E128K | SKCM | 1 |
p.F245L | KIRC | 1 |
p.W1374X | SKCM | 1 |
p.L1564M | THYM | 1 |
p.E389K | SKCM | 1 |
p.N309Y | LIHC | 1 |
p.N1236K | LUSC | 1 |
p.S147F | SKCM | 1 |
p.D490N | SKCM | 1 |
p.E935K | LUAD | 1 |
p.L106H | SARC | 1 |
p.K1496R | LIHC | 1 |
p.E796D | THYM | 1 |
p.R277I | COAD | 1 |
p.R738T | BLCA | 1 |
p.I1290F | SKCM | 1 |
p.F604V | UCEC | 1 |
p.I1702S | UCEC | 1 |
p.W767S | SKCM | 1 |
p.G1087E | SKCM | 1 |
p.I1567V | STAD | 1 |
p.P967S | STAD | 1 |
p.P1004L | SKCM | 1 |
p.H1390Y | SKCM | 1 |
p.V1128I | STAD | 1 |
p.L127H | COAD | 1 |
p.A410D | ESCA | 1 |
p.N1382S | LUSC | 1 |
p.N1634T | STAD | 1 |
p.W1374* | SKCM | 1 |
p.R498C | UCEC | 1 |
p.K36X | COAD | 1 |
p.K1496N | COAD | 1 |
p.R305C | SKCM | 1 |
p.K690R | SARC | 1 |
p.R280Q | SKCM | 1 |
p.K1223E | SKCM | 1 |
p.L607V | KIRP | 1 |
p.D1218E | LGG | 1 |
p.G1434V | LGG | 1 |
p.Y1391C | STAD | 1 |
p.E1301K | LGG | 1 |
p.K125Q | UCEC | 1 |
p.P333S | SKCM | 1 |
p.W1209* | BLCA | 1 |
p.G858V | LUSC | 1 |
p.H778R | UCEC | 1 |
p.D174N | SKCM | 1 |
p.D1016Y | BLCA | 1 |
p.Y962H | UCEC | 1 |
p.L1123F | COAD | 1 |
p.T1320I | SKCM | 1 |
p.L24R | STAD | 1 |
p.K352N | ACC | 1 |
p.D213Y | LUAD | 1 |
p.R280Q | UCEC | 1 |
p.R1589M | READ | 1 |
p.V783E | KIRC | 1 |
p.Q1701H | UCEC | 1 |
p.L1328F | SKCM | 1 |
p.E326D | READ | 1 |
p.P1156S | SKCM | 1 |
p.S1552L | SKCM | 1 |
p.P708L | SKCM | 1 |
p.S533* | SKCM | 1 |
p.E29D | GBM | 1 |
p.G1439R | SKCM | 1 |
p.I1149M | HNSC | 1 |
p.Q901* | LUAD | 1 |
p.R1057S | STAD | 1 |
p.E1295G | STAD | 1 |
p.Q792* | LUAD | 1 |
p.S445C | SKCM | 1 |
p.P823L | STAD | 1 |
p.D1184H | ACC | 1 |
p.W1515X | STAD | 1 |
p.Q249R | LIHC | 1 |
p.R1626* | UCEC | 1 |
p.I1256V | HNSC | 1 |
p.S107F | SKCM | 1 |
p.S890F | CESC | 1 |
p.I470T | UCEC | 1 |
p.P154S | SKCM | 1 |
p.Q1568K | STAD | 1 |
p.I11V | BLCA | 1 |
p.V1139A | COAD | 1 |
p.I1136M | LUAD | 1 |
p.P472S | SKCM | 1 |
p.T1315I | UCEC | 1 |
p.P1544R | HNSC | 1 |
p.G592E | SKCM | 1 |
p.R151C | HNSC | 1 |
p.R399X | SKCM | 1 |
p.R1346Q | PAAD | 1 |
p.H880Y | SKCM | 1 |
p.P244S | SKCM | 1 |
p.D1288Y | UCEC | 1 |
p.Q772* | SKCM | 1 |
p.S890C | BLCA | 1 |
p.D1372N | SKCM | 1 |
p.A841V | MESO | 1 |
p.E197X | COAD | 1 |
p.G609R | LUAD | 1 |
p.G1115D | LGG | 1 |
p.I1380V | BRCA | 1 |
p.L1193F | SKCM | 1 |
p.A469V | UCEC | 1 |
p.R349* | SKCM | 1 |
p.K428T | READ | 1 |
p.F1006L | LUAD | 1 |
p.V821A | KIRC | 1 |
p.S1477G | SKCM | 1 |
p.V606M | BLCA | 1 |
p.W1515* | STAD | 1 |
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TissGeneCNV for ARAP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ARAP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG987597 | ARAP2-PACS1 | chr4:36066586 | chr11:65983613 | |
Chimerdb3.0 | ChiTaRs | NA | BF376184 | SCCPDH-ARAP2 | chr1:246927630 | chr4:36130852 |
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TissGeneNet for ARAP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ARAP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ARAP2 |
TissGeneDrug for ARAP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ARAP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GWASCAT |