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| TissGeneSummary for CHD5 |
 Gene summary |
| Basic gene information | Gene symbol | CHD5 |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHD5 | |
| BioGPS: 101928723 | ||
| Pathway | NCI Pathway Interaction Database: CHD5 | |
| KEGG: CHD5 | ||
| REACTOME: CHD5 | ||
| Pathway Commons: CHD5 | ||
| Context | iHOP: CHD5 | |
| ligand binding site mutation search in PubMed: CHD5 | ||
| UCL Cancer Institute: CHD5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of CHD5 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CHD5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 0.308617431 | 1.985619354 | -1.677001923 | 2.77E-11 | 7.57E-10 |
| KIRC | -3.127738766 | 0.552257067 | -3.679995833 | 4.21E-44 | 2.36E-42 |
| KIRP | -1.838434252 | 1.123031373 | -2.961465625 | 2.84E-08 | 1.97E-07 |
| LUSC | -2.68968174 | -1.392299387 | -1.297382353 | 5.82E-07 | 1.50E-06 |
| LUAD | -2.800583498 | -1.539950739 | -1.260632759 | 3.51E-07 | 1.26E-06 |
| COAD | -1.268797954 | -0.1371018 | -1.131696154 | 0.0134 | 0.028421491 |
| STAD | -1.419849877 | 0.526618873 | -1.94646875 | 0.000226 | 0.001540224 |
| BLCA | -2.66723014 | 0.312722491 | -2.979952632 | 3.38E-05 | 0.000488125 |
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| TissGene-miRNA for CHD5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-24-3p | MIMAT0000080 | 0.004 | -0.32 | 80 |
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| TissGeneMut for CHD5 |
| TissGeneSNV for CHD5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P878S | SKCM | 2 |
| p.T271M | COAD | 2 |
| p.A1708T | UCEC | 2 |
| p.Q880H | UCEC | 2 |
| p.Q1840K | LUAD | 2 |
| p.D1038N | SKCM | 1 |
| p.T461A | LUAD | 1 |
| p.V368I | SARC | 1 |
| p.L1812Q | LUAD | 1 |
| p.D359N | STAD | 1 |
| p.I631T | STAD | 1 |
| p.E79K | SKCM | 1 |
| p.R1618* | BLCA | 1 |
| p.M548I | SKCM | 1 |
| p.V311M | ESCA | 1 |
| p.D1734N | SKCM | 1 |
| p.T699I | PRAD | 1 |
| p.I1219F | HNSC | 1 |
| p.K381T | LIHC | 1 |
| p.P1387T | LUAD | 1 |
| p.S759F | SKCM | 1 |
| p.R712H | CESC | 1 |
| p.H747N | STAD | 1 |
| p.V680L | LUAD | 1 |
| p.R1325W | LGG | 1 |
| p.S303C | LIHC | 1 |
| p.K918M | SARC | 1 |
| p.R949W | BRCA | 1 |
| p.E1535K | BLCA | 1 |
| p.P250T | LUAD | 1 |
| p.P1886S | SKCM | 1 |
| p.K162R | THYM | 1 |
| p.S1183F | SKCM | 1 |
| p.E794K | BLCA | 1 |
| p.A909V | GBM | 1 |
| p.P1242L | SKCM | 1 |
| p.D694N | COAD | 1 |
| p.L1825F | STAD | 1 |
| p.K1235N | UCEC | 1 |
| p.H995Q | CHOL | 1 |
| p.G352S | SKCM | 1 |
| p.D371N | SKCM | 1 |
| p.R65Q | UCS | 1 |
| p.L659P | SKCM | 1 |
| p.R540H | UCEC | 1 |
| p.M1281I | SKCM | 1 |
| p.V980I | SKCM | 1 |
| p.G606R | SKCM | 1 |
| p.S1545L | STAD | 1 |
| p.A801V | PRAD | 1 |
| p.E765K | SKCM | 1 |
| p.D1119N | PAAD | 1 |
| p.E1484K | SKCM | 1 |
| p.N1140I | DLBC | 1 |
| p.M1167V | OV | 1 |
| p.R65Q | STAD | 1 |
| p.R1404T | LUAD | 1 |
| p.F775L | THYM | 1 |
| p.E1615K | BLCA | 1 |
| p.P1852S | UCEC | 1 |
| p.R1427X | COAD | 1 |
| p.R584H | SARC | 1 |
| p.D1084N | READ | 1 |
| p.N1087I | OV | 1 |
| p.S165N | BLCA | 1 |
| p.D1600Y | LIHC | 1 |
| p.P1632L | GBM | 1 |
| p.E504* | UCEC | 1 |
| p.P177S | SARC | 1 |
| p.G1012D | SKCM | 1 |
| p.R296S | UCEC | 1 |
| p.A1836T | PAAD | 1 |
| p.V537A | UCEC | 1 |
| p.P553S | SKCM | 1 |
| p.P1632A | BLCA | 1 |
| p.H1135P | LUAD | 1 |
| p.E646* | STAD | 1 |
| p.H1820Y | BRCA | 1 |
| p.S1183P | STAD | 1 |
| p.M1209I | LUAD | 1 |
| p.R65Q | READ | 1 |
| p.S1132G | UCEC | 1 |
| p.S524F | SKCM | 1 |
| p.S305C | LUAD | 1 |
| p.P499L | SKCM | 1 |
| p.E402K | SKCM | 1 |
| p.G1016E | SKCM | 1 |
| p.K567N | LUSC | 1 |
| p.N444K | KIRC | 1 |
| p.P682_splice | LUSC | 1 |
| p.T1815M | BLCA | 1 |
| p.F201L | HNSC | 1 |
| p.E1199K | SKCM | 1 |
| p.V228I | KIRP | 1 |
| p.N939K | ESCA | 1 |
| p.S1496C | LUAD | 1 |
| p.D1481N | COAD | 1 |
| p.I306M | KIRC | 1 |
| p.K68I | LIHC | 1 |
| p.A1231V | LIHC | 1 |
| p.G453S | LUAD | 1 |
| p.P230L | SKCM | 1 |
| p.D37N | SKCM | 1 |
| p.G517E | SKCM | 1 |
| p.A1594T | BRCA | 1 |
| p.T732A | BLCA | 1 |
| p.P231L | LUAD | 1 |
| p.A640V | STAD | 1 |
| p.D1580V | BLCA | 1 |
| p.S1658I | HNSC | 1 |
| p.K257N | STAD | 1 |
| p.E1664K | READ | 1 |
| p.G559E | LUAD | 1 |
| p.R584H | PRAD | 1 |
| p.C346R | COAD | 1 |
| p.D1649G | LUAD | 1 |
| p.E1198K | SKCM | 1 |
| p.D359N | COAD | 1 |
| p.E1303K | SKCM | 1 |
| p.P1242S | SKCM | 1 |
| p.D1054N | SKCM | 1 |
| p.D669V | UCEC | 1 |
| p.R787C | LUAD | 1 |
| p.W591* | SKCM | 1 |
| p.A909D | COAD | 1 |
| p.R791W | BRCA | 1 |
| p.P1589H | LUAD | 1 |
| p.R791Q | PAAD | 1 |
| p.R1792M | UCEC | 1 |
| p.A1790V | UCEC | 1 |
| p.V220I | LIHC | 1 |
| p.E951K | HNSC | 1 |
| p.G1176D | UCEC | 1 |
| p.D555H | LUAD | 1 |
| p.G1938E | SKCM | 1 |
| p.G1076E | SKCM | 1 |
| p.V213A | STAD | 1 |
| p.P225S | CESC | 1 |
| p.D635N | UCEC | 1 |
| p.S796F | SKCM | 1 |
| p.W591X | LIHC | 1 |
| p.V1453A | UCEC | 1 |
| p.S1153L | GBM | 1 |
| p.G1138S | STAD | 1 |
| p.R1492W | STAD | 1 |
| p.E1664K | SKCM | 1 |
| p.R1133C | STAD | 1 |
| p.C349R | ESCA | 1 |
| p.G1423F | LUAD | 1 |
| p.L1768H | KIRC | 1 |
| p.D1084N | ESCA | 1 |
| p.R810H | STAD | 1 |
| p.A1260V | ESCA | 1 |
| p.D1580E | BRCA | 1 |
| p.G559E | SKCM | 1 |
| p.P498S | SKCM | 1 |
| p.R810C | SKCM | 1 |
| p.R897M | LUAD | 1 |
| p.F278I | SKCM | 1 |
| p.E1652D | LGG | 1 |
| p.R327H | PAAD | 1 |
| p.R331M | KIRC | 1 |
| p.R1621W | PRAD | 1 |
| p.D261N | SKCM | 1 |
| p.G1536E | SKCM | 1 |
| p.N1683H | GBM | 1 |
| p.D676N | SKCM | 1 |
| p.G1196S | SKCM | 1 |
| p.W591X | SKCM | 1 |
| p.A1836T | LUSC | 1 |
| p.P1667T | SARC | 1 |
| p.R712H | STAD | 1 |
| p.Q1092H | UCS | 1 |
| p.K853N | ESCA | 1 |
| p.A206V | SARC | 1 |
| p.R1085K | SKCM | 1 |
| p.N1011D | LUSC | 1 |
| p.D38G | UCS | 1 |
| p.R581H | ESCA | 1 |
| p.G698D | PCPG | 1 |
| p.A942T | UCEC | 1 |
| p.L708F | LUSC | 1 |
| p.D1248N | SKCM | 1 |
| p.D1358Y | LUAD | 1 |
| p.R327C | ESCA | 1 |
| p.R1344H | UCEC | 1 |
| p.E1371K | BLCA | 1 |
| p.L529V | GBM | 1 |
| p.P553L | SKCM | 1 |
| p.Q1863K | LUAD | 1 |
| p.K918N | UCEC | 1 |
| p.R1457Q | UCEC | 1 |
| p.G288A | UCEC | 1 |
| p.W591* | LIHC | 1 |
| p.D371H | HNSC | 1 |
| p.R1069Q | STAD | 1 |
| p.E1297K | STAD | 1 |
| p.G1090R | MESO | 1 |
| p.T760I | SKCM | 1 |
| p.D668N | SKCM | 1 |
| p.E354K | UCEC | 1 |
| p.V348L | LUAD | 1 |
| p.R851C | COAD | 1 |
| p.K1031M | LUAD | 1 |
| p.R581L | LUAD | 1 |
| p.F36I | PRAD | 1 |
| p.D620E | ACC | 1 |
| p.T536M | STAD | 1 |
| p.A1598T | STAD | 1 |
| p.K853R | ESCA | 1 |
| p.P1632T | THYM | 1 |
| p.W394* | UCEC | 1 |
| p.R1151Q | STAD | 1 |
| p.D1668V | STAD | 1 |
| p.C1834Y | LUSC | 1 |
| p.G1937R | PAAD | 1 |
| p.A1162S | GBM | 1 |
| p.E706K | UCS | 1 |
| p.E1783K | UCEC | 1 |
| p.R584H | BLCA | 1 |
| p.V187I | BLCA | 1 |
| p.R1136H | BLCA | 1 |
| p.E646X | STAD | 1 |
| p.V778I | BLCA | 1 |
| p.R1902C | PRAD | 1 |
| p.S1120L | HNSC | 1 |
| p.C992* | LUAD | 1 |
| p.H439R | THYM | 1 |
| p.R584C | LUAD | 1 |
| p.D1119N | UCEC | 1 |
| p.G335A | UCS | 1 |
| p.P1407L | SKCM | 1 |
| p.D1546N | SKCM | 1 |
| p.E906* | HNSC | 1 |
| p.E1061Q | BLCA | 1 |
| p.Q1331H | UCEC | 1 |
| p.A206S | LUAD | 1 |
| p.E295K | CESC | 1 |
| p.A801V | PAAD | 1 |
| p.R1164H | STAD | 1 |
| p.R1346H | STAD | 1 |
| p.E1676K | SKCM | 1 |
| p.L852H | LIHC | 1 |
| p.R1906C | PRAD | 1 |
| p.E896* | LUSC | 1 |
| p.A772V | BRCA | 1 |
| p.C457S | DLBC | 1 |
| p.C442G | DLBC | 1 |
| p.L659V | LUAD | 1 |
| p.E840K | UCEC | 1 |
| p.G563S | SKCM | 1 |
| p.A304T | UCEC | 1 |
| p.D1953A | UCEC | 1 |
| p.W1743* | GBM | 1 |
| p.Y1811C | LUSC | 1 |
| p.L1653V | HNSC | 1 |
| p.G1522V | BLCA | 1 |
| p.L158P | GBM | 1 |
| p.A139S | PAAD | 1 |
| p.R1136C | STAD | 1 |
| p.T721S | OV | 1 |
| Top |
| TissGeneCNV for CHD5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CHD5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CHD5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| COAD (tumor) | COAD (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| KICH (tumor) | KICH (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| STAD (tumor) | STAD (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| THCA (tumor) | THCA (normal) |
| CHD5, CHD4, MYC, CBX3 (tumor) | CHD5, CHD4, MYC, CBX3 (normal) |
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| TissGeneProg for CHD5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CHD5 |
| TissGeneDrug for CHD5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CHD5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027819 | Neuroblastoma | 12 | BeFree,CTD_human |
| umls:C0700095 | Central neuroblastoma | 10 | BeFree |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0007107 | Malignant neoplasm of larynx | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0085648 | Synovial Cyst | 1 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0280324 | Laryngeal Squamous Cell Carcinoma | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0595989 | Carcinoma of larynx | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
| umls:C1258666 | Myxoid cyst | 1 | BeFree |
| umls:C1512419 | Hereditary Melanoma | 1 | BeFree |
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