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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for MRC1
check button Gene summary
Basic gene informationGene symbolMRC1
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRC1
BioGPS: 101928757
PathwayNCI Pathway Interaction Database: MRC1
KEGG: MRC1
REACTOME: MRC1
Pathway Commons: MRC1
ContextiHOP: MRC1
ligand binding site mutation search in PubMed: MRC1
UCL Cancer Institute: MRC1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Lung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSC
Reference showing the relevant tissue of MRC1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for MRC1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC0.7592083264.878653424-4.1194450984.74E-249.20E-23
LUAD2.3426212744.896231619-2.5536103456.91E-167.67E-15
BRCA-1.0936139651.125207965-2.218821933.51E-212.73E-20
LIHC0.3803858952.345409895-1.9650241.15E-111.77E-10
KIRP-1.94645448-0.10212323-1.844331252.66E-061.22E-05
KICH-1.520810105-0.392918105-1.1278920.006820.012695338
COAD-0.059085491.20401451-1.26310.0001850.000629402


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TissGene-miRNA for MRC1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for MRC1
TissGeneSNV for MRC1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A474TUCEC2
p.S356NKIRP1
p.N348HUCEC1
p.W909CUCEC1
p.G595EBRCA1
p.S1316YLUSC1
p.A169VUCEC1
p.A1337TSTAD1
p.D408EACC1
p.R1357GLUAD1
p.E124*UCEC1
p.Y89CBRCA1
p.D223ESTAD1
p.W366RSTAD1
p.A621EBRCA1
p.I580VLUSC1
p.R924*UCEC1
p.G76ROV1
p.R476WUCEC1
p.I1345TUCEC1
p.K382NSTAD1
p.F71LSTAD1
p.E643KUCEC1
p.V805AUCEC1
p.A399PLUAD1
p.C362GLUAD1
p.T264PUCEC1
p.L414PTHYM1
p.A387SLUAD1
p.K323TUCEC1
p.E394DBLCA1
p.P1325SLUSC1
p.S1316CLUAD1
p.W100RLUSC1
p.S64CBLCA1
p.S412FTHYM1
p.G215DACC1
p.R1329WLUAD1
p.S400RSKCM1


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TissGeneCNV for MRC1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for MRC1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for MRC1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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COAD (tumor)COAD (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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HNSC (tumor)HNSC (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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KICH (tumor)KICH (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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KIRC (tumor)KIRC (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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KIRP (tumor)KIRP (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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LIHC (tumor)LIHC (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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LUAD (tumor)LUAD (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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LUSC (tumor)LUSC (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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PRAD (tumor)PRAD (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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STAD (tumor)STAD (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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THCA (tumor)THCA (normal)
MRC1, CHEK2 (tumor)MRC1, CHEK2 (normal)
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TissGeneProg for MRC1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for MRC1
TissGeneDrug for MRC1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for MRC1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C1333990Hereditary Nonpolyposis Colorectal Cancer314BeFree
umls:C0009402Colorectal Carcinoma147BeFree
umls:C1527249Colorectal Cancer144BeFree,GAD
umls:C0476089Endometrial Carcinoma56BeFree
umls:C0007102Malignant tumor of colon38BeFree
umls:C0007103Malignant neoplasm of endometrium37BeFree
umls:C1883486Uterine Corpus Cancer37BeFree
umls:C0596263Carcinogenesis34BeFree
umls:C0699790Colon Carcinoma27BeFree
umls:C0265325Turcot syndrome (disorder)18BeFree
umls:C0029925Ovarian Carcinoma17BeFree
umls:C0334108Multiple polyps15BeFree
umls:C0006142Malignant neoplasm of breast14BeFree
umls:C0009404Colorectal Neoplasms13BeFree
umls:C0678222Breast Carcinoma13BeFree
umls:C1140680Malignant neoplasm of ovary13BeFree
umls:C0376358Malignant neoplasm of prostate12BeFree
umls:C0024623Malignant neoplasm of stomach11BeFree
umls:C0699791Stomach Carcinoma11BeFree
umls:C1321489Torre-Muir syndrome11BeFree
umls:C0600139Prostate carcinoma10BeFree
umls:C0001430Adenoma8BeFree
umls:C0027672Neoplastic Syndromes, Hereditary8BeFree
umls:C0005684Malignant neoplasm of urinary bladder6BeFree
umls:C0025202melanoma6BeFree
umls:C0026780Mumps6BeFree
umls:C0027831Neurofibromatosis 16BeFree
umls:C0178874Tumor Progression6BeFree
umls:C0699885Carcinoma of bladder6BeFree
umls:C0032580Adenomatous Polyposis Coli5BeFree
umls:C1333600Hereditary Malignant Neoplasm5BeFree
umls:C0001418Adenocarcinoma4BeFree
umls:C0017638Glioma4BeFree
umls:C0235974Pancreatic carcinoma4BeFree
umls:C0346647Malignant neoplasm of pancreas4BeFree
umls:C0376545Hematologic Neoplasms4BeFree
umls:C0677886Epithelial ovarian cancer4BeFree
umls:C0919267ovarian neoplasm4BeFree
umls:C0004114Astrocytoma3BeFree
umls:C0004352Autistic Disorder3BeFree
umls:C0007113Rectal Carcinoma3BeFree
umls:C0007131Non-Small Cell Lung Carcinoma3BeFree
umls:C0017636Glioblastoma3BeFree
umls:C0035920Rubella3BeFree
umls:C0036503Sebaceous Gland Neoplasms3BeFree
umls:C0085136Central Nervous System Neoplasms3BeFree
umls:C0260037Multiple tumors3BeFree
umls:C0302592Cervix carcinoma3BeFree
umls:C0699893Skin carcinoma3BeFree
umls:C1261473Sarcoma3BeFree
umls:C1861975Cafe au lait spots, multiple3BeFree
umls:C2239176Liver carcinoma3BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0005695Bladder Neoplasm2BeFree
umls:C0006118Brain Neoplasms2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0007138Carcinoma, Transitional Cell2BeFree
umls:C0014175Endometriosis2BeFree
umls:C0023343Leprosy2BeFree
umls:C0023418leukemia2BeFree
umls:C0024299Lymphoma2BeFree
umls:C0025007Measles2BeFree
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0033626Protein Deficiency2BeFree
umls:C0036202Sarcoidosis2BeFree,GAD
umls:C0037286Skin Neoplasms2BeFree
umls:C0041296Tuberculosis2BeFree,LHGDN
umls:C0041327Tuberculosis, Pulmonary2BeFree
umls:C0206677Adenomatous Polyps2BeFree
umls:C0206687Carcinoma, Endometrioid2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C0281361Adenocarcinoma of pancreas2BeFree
umls:C0684249Carcinoma of lung2BeFree
umls:C0699889Malignant Female Reproductive System Neoplasm2BeFree
umls:C1168401Squamous cell carcinoma of the head and neck2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0003864Arthritis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree,GAD
umls:C0007095Carcinoid Tumor1BeFree
umls:C0007114Malignant neoplasm of skin1BeFree
umls:C0007130Mucinous Adenocarcinoma1BeFree
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0013595Eczema1BeFree
umls:C0014038Encephalitis1BeFree
umls:C0014170Endometrial Neoplasms1BeFree
umls:C0014173Endometrial Hyperplasia1BeFree
umls:C0015625Fanconi Anemia1BeFree
umls:C0018939Hematological Disease1BeFree
umls:C0019163Hepatitis B1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0021364Male infertility1BeFree
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0021670insulinoma1BeFree
umls:C0022572keratoacanthoma1BeFree
umls:C0023492Leukemia, T-Cell1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0024314Lymphoproliferative Disorders1BeFree
umls:C0025290Aseptic Meningitis1BeFree
umls:C0025322Premature Menopause1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0030805Bullous pemphigoid1BeFree
umls:C0030809Pemphigus Vulgaris1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0032584polyps1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0085409Polyendocrinopathies, Autoimmune1BeFree
umls:C0152171Idiopathic pulmonary hypertension1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0153567Uterine Cancer1BeFree
umls:C0153594Malignant neoplasm of testis1BeFree
umls:C0162820Dermatitis, Allergic Contact1CTD_human
umls:C0175754Agenesis of corpus callosum1BeFree
umls:C0206651Sarcoma, Clear Cell1BeFree
umls:C0206754Neuroendocrine Tumors1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0242584Autoimmune thrombocytopenia1BeFree
umls:C0265385Autosomal dominant hereditary disorder1BeFree
umls:C0275814Streptococcal lymphadenitis of swine1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0278803Adenocarcinoma of small intestine1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0279680Transitional cell carcinoma of bladder1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0280232stage, cervical cancer1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0334281Insulinoma, malignant1BeFree
umls:C0334299Carcinoid tumor no ICD-O subtype1BeFree
umls:C0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1BeFree
umls:C0398650Immune thrombocytopenic purpura1BeFree
umls:C0426576Gastrointestinal symptom1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0598766Leukemogenesis1BeFree
umls:C0677944Sentinel node (disorder)1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0730607Severe chronic obstructive pulmonary disease1BeFree
umls:C0751356Idiopathic Inflammatory Myopathies1BeFree
umls:C0851886Pneumocystis Infections1LHGDN
umls:C0854778Pancreatic carcinoma resectable1BeFree
umls:C0855197Testicular malignant germ cell tumor1BeFree
umls:C0948380Colorectal cancer metastatic1BeFree
umls:C1336076Sporadic Breast Carcinoma1BeFree
umls:C1336708Testicular Germ Cell Tumor1BeFree
umls:C1336745Thymic Lymphoma1BeFree
umls:C1510586Autism Spectrum Disorders1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1519702Turcot Syndrome Type 11BeFree
umls:C1562585Leprosy, Multibacillary1BeFree
umls:C1562908Leprosy, Paucibacillary1BeFree
umls:C1658953tumor vasculature1BeFree
umls:C1708349Hereditary Diffuse Gastric Cancer1BeFree
umls:C1836830Developmental regression1BeFree
umls:C2973725Pulmonary arterial hypertension1BeFree
umls:C3469521FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)1BeFree
umls:C3472623Serrated adenocarcinoma1BeFree
umls:C3714844Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia1BeFree
umls:C3811653Experimental Organism Basal Cell Carcinoma1BeFree