TissGeneSummary for ABCC6 |
Gene summary |
Basic gene information | Gene symbol | ABCC6 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ABCC6 | |
BioGPS: 101930322 | ||
Pathway | NCI Pathway Interaction Database: ABCC6 | |
KEGG: ABCC6 | ||
REACTOME: ABCC6 | ||
Pathway Commons: ABCC6 | ||
Context | iHOP: ABCC6 | |
ligand binding site mutation search in PubMed: ABCC6 | ||
UCL Cancer Institute: ABCC6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of ABCC6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ABCC6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.416779559 | 2.746194951 | -4.16297451 | 3.92E-25 | 8.83E-24 |
BRCA | -0.995675792 | 1.143147015 | -2.138822807 | 5.46E-19 | 3.62E-18 |
KICH | -1.084942775 | 2.325565225 | -3.410508 | 5.14E-10 | 3.45E-09 |
LUAD | 1.344839846 | 2.933250191 | -1.588410345 | 3.06E-13 | 2.52E-12 |
KIRP | 2.476374975 | 3.574649975 | -1.098275 | 0.0223 | 0.044759714 |
HNSC | -3.736788542 | -2.406704821 | -1.330083721 | 0.00044 | 0.001666667 |
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TissGene-miRNA for ABCC6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ABCC6 |
TissGeneSNV for ABCC6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R87W | SKCM | 3 |
p.E255K | SKCM | 2 |
p.P895S | SKCM | 2 |
p.E242* | UCEC | 2 |
p.Q593* | SKCM | 2 |
p.R1141Q | SKCM | 2 |
p.L1313M | UCEC | 1 |
p.S66F | UCEC | 1 |
p.E690K | COAD | 1 |
p.G226E | SKCM | 1 |
p.R526W | PAAD | 1 |
p.L946I | DLBC | 1 |
p.V1055I | SKCM | 1 |
p.K392* | SKCM | 1 |
p.A730V | COAD | 1 |
p.A302V | SKCM | 1 |
p.E641D | SKCM | 1 |
p.R290W | STAD | 1 |
p.E1037Q | HNSC | 1 |
p.R1468G | KIRP | 1 |
p.H1336P | LIHC | 1 |
p.S706F | BLCA | 1 |
p.G1327E | DLBC | 1 |
p.V596M | SKCM | 1 |
p.E1427K | STAD | 1 |
p.G429V | STAD | 1 |
p.D627N | SKCM | 1 |
p.R769K | SKCM | 1 |
p.R807Q | SKCM | 1 |
p.R807Q | BLCA | 1 |
p.S238L | SKCM | 1 |
p.G741E | SKCM | 1 |
p.R1235Q | UCEC | 1 |
p.A271P | TGCT | 1 |
p.Y171* | UCEC | 1 |
p.W347* | SKCM | 1 |
p.I1422L | BRCA | 1 |
p.T364M | CESC | 1 |
p.R64Q | THCA | 1 |
p.R297C | STAD | 1 |
p.S397F | SKCM | 1 |
p.Q593X | SKCM | 1 |
p.G276C | LUAD | 1 |
p.V693M | COAD | 1 |
p.E242K | SKCM | 1 |
p.D1368N | SKCM | 1 |
p.L358F | STAD | 1 |
p.T806A | UCEC | 1 |
p.E253Q | LUAD | 1 |
p.W506X | SKCM | 1 |
p.G863R | SKCM | 1 |
p.R1164X | PRAD | 1 |
p.A700D | SKCM | 1 |
p.E609* | UCEC | 1 |
p.L1272I | SARC | 1 |
p.L81Q | THYM | 1 |
p.R899G | LUAD | 1 |
p.G663S | SKCM | 1 |
p.G755R | GBM | 1 |
p.V1202M | UCEC | 1 |
p.K892X | SKCM | 1 |
p.D1397G | STAD | 1 |
p.R1164* | PRAD | 1 |
p.G666E | SKCM | 1 |
p.G741R | SKCM | 1 |
p.L677F | SKCM | 1 |
p.G992E | SKCM | 1 |
p.P644S | SKCM | 1 |
p.R1314Q | READ | 1 |
p.S670F | SKCM | 1 |
p.W721L | LUAD | 1 |
p.G1475E | SKCM | 1 |
p.G861E | SKCM | 1 |
p.R473K | SKCM | 1 |
p.R1114H | STAD | 1 |
p.W638* | UCEC | 1 |
p.D1058E | THYM | 1 |
p.R487L | LUSC | 1 |
p.A1428D | SKCM | 1 |
p.P329S | SKCM | 1 |
p.D235Y | ACC | 1 |
p.E422K | SKCM | 1 |
p.S1065F | SKCM | 1 |
p.R1114C | UCEC | 1 |
p.V442I | STAD | 1 |
p.V435I | STAD | 1 |
p.K484M | SKCM | 1 |
p.Y43* | UCEC | 1 |
p.R987H | STAD | 1 |
p.W506* | SKCM | 1 |
p.V1202L | STAD | 1 |
p.R1268Q | COAD | 1 |
p.S1343R | KIRC | 1 |
p.P1329A | PAAD | 1 |
p.L425V | OV | 1 |
p.D898N | SKCM | 1 |
p.N95K | BRCA | 1 |
p.L374F | SKCM | 1 |
p.G529S | KIRC | 1 |
p.A972V | READ | 1 |
p.G863E | SKCM | 1 |
p.S1157I | ACC | 1 |
p.G1042S | PRAD | 1 |
p.E1369A | LIHC | 1 |
p.E1320K | BLCA | 1 |
p.T630S | SKCM | 1 |
p.R1141Q | HNSC | 1 |
p.P913R | LUAD | 1 |
p.A76V | THYM | 1 |
p.V1463L | LIHC | 1 |
p.P644A | LUAD | 1 |
p.W1026* | SKCM | 1 |
p.G621E | SKCM | 1 |
p.G755E | SKCM | 1 |
p.E1427K | CESC | 1 |
p.M1006T | BLCA | 1 |
p.V1202R | STAD | 1 |
p.P909S | SKCM | 1 |
p.Q1421H | OV | 1 |
p.A728V | PAAD | 1 |
p.V1191G | LIHC | 1 |
p.L168V | LIHC | 1 |
p.R1015Q | DLBC | 1 |
p.R241K | HNSC | 1 |
p.K892* | SKCM | 1 |
p.L1417F | SKCM | 1 |
p.E1266K | BLCA | 1 |
p.E1266K | PAAD | 1 |
p.K1407E | LIHC | 1 |
p.F1035L | UCEC | 1 |
p.P450L | SKCM | 1 |
p.V1154I | STAD | 1 |
p.G917X | KIRP | 1 |
p.A624V | OV | 1 |
p.E1437K | BLCA | 1 |
p.S836F | SKCM | 1 |
p.G61C | BRCA | 1 |
p.L1097I | DLBC | 1 |
p.V1298I | SKCM | 1 |
p.A1014V | SKCM | 1 |
p.N259S | STAD | 1 |
p.E1129* | LUAD | 1 |
p.L1171F | BRCA | 1 |
p.G917* | LUAD | 1 |
p.K375N | SKCM | 1 |
p.G276S | STAD | 1 |
p.R64W | LGG | 1 |
p.G1322R | SKCM | 1 |
p.V534L | COAD | 1 |
p.P664L | SKCM | 1 |
p.G1405C | STAD | 1 |
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TissGeneCNV for ABCC6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ABCC6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | W79014 | ABCC6-SEMA4G | chr16:16249736 | chr10:102743741 | |
TCGAfusionPortal | PRADA | LAML | TCGA-AB-2846-03A | ABCC6-C16orf70 | In-frame | Chr16:16253339 | Chr16:67165189 |
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TissGeneNet for ABCC6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ABCC6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ABCC6 |
TissGeneDrug for ABCC6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ABCC6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033847 | Pseudoxanthoma Elasticum | 129 | BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT |
umls:C0473583 | Nevus elasticus | 53 | BeFree |
umls:C0010068 | Coronary heart disease | 8 | BeFree,GAD |
umls:C0010054 | Coronary Arteriosclerosis | 7 | BeFree,GAD |
umls:C0023467 | Leukemia, Myelocytic, Acute | 7 | BeFree |
umls:C1956346 | Coronary Artery Disease | 7 | BeFree,LHGDN |
umls:C3276161 | ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 2 | 6 | CLINVAR,UNIPROT |
umls:C0006663 | Calcinosis | 5 | BeFree,GAD |
umls:C0025517 | Metabolic Diseases | 4 | BeFree |
umls:C1859727 | Arterial calcification of infancy | 4 | BeFree,ORPHANET |
umls:C0002982 | Angioid Streaks | 3 | BeFree,GAD |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
umls:C0009782 | Connective Tissue Diseases | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
umls:C0410787 | Hereditary Connective Tissue Disorder | 2 | BeFree |
umls:C0524909 | Hepatitis B, Chronic | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0015393 | Eye Abnormalities | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | GAD |
umls:C0021655 | Insulin Resistance | 1 | GAD |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
umls:C0025312 | Meningomyelocele | 1 | BeFree |
umls:C0029456 | Osteoporosis | 1 | BeFree |
umls:C0031069 | Familial Mediterranean Fever | 1 | LHGDN |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0035309 | Retinal Diseases | 1 | GAD |
umls:C0037274 | Dermatologic disorders | 1 | BeFree,LHGDN |
umls:C0042373 | Vascular Diseases | 1 | BeFree |
umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
umls:C0239849 | Harlequin Fetus | 1 | BeFree |
umls:C0242339 | Dyslipidemias | 1 | BeFree |
umls:C0242656 | Disease Progression | 1 | CTD_human |
umls:C0272315 | Coagulation factor deficiency syndrome | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
umls:C0559758 | Multisystem disorder | 1 | BeFree |
umls:C0746556 | metabolic disturbance | 1 | BeFree |
umls:C0877104 | Retinal toxicity | 1 | BeFree |
umls:C0948008 | Ischemic stroke | 1 | BeFree |
umls:C1397307 | Cardiac fibrosis | 1 | BeFree |
umls:C1859372 | Calcification of Joints and Arteries | 1 | BeFree |
umls:C1861502 | COLCHICINE RESISTANCE | 1 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
umls:C3665346 | Unspecified visual loss | 1 | BeFree |
umls:C0264955 | Idiopathic arterial calcification of infancy | 0 | ORPHANET |
umls:C1867450 | Pseudoxanthoma Elasticum, Incomplete | 0 | CLINVAR |