![]() |
TissGeneSummary for OLIG2 |
![]() |
Basic gene information | Gene symbol | OLIG2 |
Gene name | oligodendrocyte lineage transcription factor 2 | |
Synonyms | BHLHB1|OLIGO2|PRKCBP2|RACK17|bHLHe19 | |
Cytomap | UCSC genome browser: 21q22.11 | |
Type of gene | protein-coding | |
RefGenes | NM_005806.3, | |
Description | basic domain, helix-loop-helix protein, class B, 1class B basic helix-loop-helix protein 1class E basic helix-loop-helix protein 19human protein kinase C-binding protein RACK17oligodendrocyte transcription factor 2oligodendrocyte-specific bHLH transc | |
Modification date | 20141207 | |
dbXrefs | MIM : 606386 | |
HGNC : HGNC | ||
Ensembl : ENSG00000205927 | ||
HPRD : 07334 | ||
Vega : OTTHUMG00000065032 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OLIG2 | |
BioGPS: 10215 | ||
Pathway | NCI Pathway Interaction Database: OLIG2 | |
KEGG: OLIG2 | ||
REACTOME: OLIG2 | ||
Pathway Commons: OLIG2 | ||
Context | iHOP: OLIG2 | |
ligand binding site mutation search in PubMed: OLIG2 | ||
UCL Cancer Institute: OLIG2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of OLIG2 | ||
Description by TissGene annotations | Cancer gene TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
![]() |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for OLIG2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.895471142 | -2.056115142 | 1.160644 | 0.000202 | 0.000499112 |
Top |
TissGene-miRNA for OLIG2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for OLIG2 |
TissGeneSNV for OLIG2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
![]() |
![]() |
![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
![]() |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A127T | READ | 1 |
p.A33T | BLCA | 1 |
p.S88A | STAD | 1 |
p.S314I | LIHC | 1 |
p.G57S | CESC | 1 |
p.A53T | STAD | 1 |
p.S88A | BLCA | 1 |
p.G74D | STAD | 1 |
p.S85C | CESC | 1 |
p.D97N | ACC | 1 |
p.S3L | STAD | 1 |
p.R56C | COAD | 1 |
p.S88A | HNSC | 1 |
p.M121K | GBM | 1 |
Top |
TissGeneCNV for OLIG2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
![]() |
Top |
TissGeneFusions for OLIG2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for OLIG2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for OLIG2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() |
Top |
TissGeneClin for OLIG2 |
TissGeneDrug for OLIG2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for OLIG2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017636 | Glioblastoma | 14 | BeFree,LHGDN |
umls:C0017638 | Glioma | 14 | BeFree,LHGDN |
umls:C0028945 | oligodendroglioma | 11 | BeFree,LHGDN |
umls:C0751396 | Well Differentiated Oligodendroglioma | 10 | BeFree |
umls:C0036341 | Schizophrenia | 6 | BeFree,GAD,LHGDN |
umls:C0004114 | Astrocytoma | 5 | BeFree,LHGDN |
umls:C0334590 | Anaplastic Oligodendroglioma | 5 | BeFree |
umls:C0006118 | Brain Neoplasms | 4 | BeFree |
umls:C0013080 | Down Syndrome | 3 | BeFree,CTD_human |
umls:C0014474 | Ependymoma | 3 | BeFree |
umls:C0334583 | Pilocytic Astrocytoma | 3 | BeFree |
umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 3 | BeFree |
umls:C0023418 | leukemia | 2 | BeFree,LHGDN |
umls:C0028768 | Obsessive-Compulsive Disorder | 2 | BeFree |
umls:C0029421 | Osteochondritis Dissecans | 2 | BeFree |
umls:C0280785 | Diffuse Astrocytoma | 2 | BeFree |
umls:C0334579 | Anaplastic astrocytoma | 2 | BeFree |
umls:C0555198 | Malignant Glioma | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
umls:C0003125 | Anorexia Nervosa | 1 | BeFree |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0017075 | Ganglioneuroma | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | LHGDN |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0037930 | Spinal Cord Neoplasms | 1 | BeFree |
umls:C0040517 | Gilles de la Tourette syndrome | 1 | BeFree |
umls:C0085136 | Central Nervous System Neoplasms | 1 | BeFree |
umls:C0151786 | Muscle Weakness | 1 | CTD_human |
umls:C0206093 | Neuroectodermal Tumors | 1 | BeFree |
umls:C0206663 | Neuroectodermal Tumor, Primitive | 1 | BeFree |
umls:C0206715 | Neoplasms, Neuroepithelial | 1 | BeFree |
umls:C0206719 | Central Neurocytoma | 1 | BeFree |
umls:C0279980 | Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 1 | BeFree |
umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
umls:C0431121 | Clear Cell Meningioma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0598766 | Leukemogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0684337 | Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 1 | BeFree |
umls:C0740858 | Substance abuse problem | 1 | BeFree |
umls:C1292758 | Precursor T-cell lymphoblastic lymphoma | 1 | BeFree |
umls:C1370500 | Tanycytic ependymoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
umls:C1622510 | Neurocytoma | 1 | BeFree |
umls:C2986550 | Pituicytoma | 1 | BeFree |
umls:C3714644 | Thymus Neoplasms | 1 | BeFree |