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| TissGeneSummary for MSLN |
 Gene summary |
| Basic gene information | Gene symbol | MSLN |
| Gene name | mesothelin | |
| Synonyms | MPF|SMRP | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001177355.1, NM_005823.5,NM_013404.4, | |
| Description | CAK1 antigenmegakaryocyte potentiating factorpre-pro-megakaryocyte-potentiating factorsoluble MPF mesothelin related protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601051 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102854 | ||
| HPRD : 03030 | ||
| Vega : OTTHUMG00000047992 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MSLN | |
| BioGPS: 10232 | ||
| Pathway | NCI Pathway Interaction Database: MSLN | |
| KEGG: MSLN | ||
| REACTOME: MSLN | ||
| Pathway Commons: MSLN | ||
| Context | iHOP: MSLN | |
| ligand binding site mutation search in PubMed: MSLN | ||
| UCL Cancer Institute: MSLN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixLungOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCLUAD,LUSCOV | |
| Reference showing the relevant tissue of MSLN | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for MSLN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -3.178680974 | -5.428511483 | 2.249830508 | 1.79E-08 | 8.65E-08 |
| PRAD | -2.777062233 | -0.057858386 | -2.719203846 | 5.95E-07 | 4.46E-06 |
| KICH | -5.335920771 | 0.318123229 | -5.654044 | 4.27E-12 | 4.38E-11 |
| STAD | 3.529648104 | -0.900583146 | 4.43023125 | 1.26E-07 | 3.30E-06 |
| LUSC | 0.455568876 | 4.732172798 | -4.276603922 | 4.17E-14 | 2.26E-13 |
| COAD | 2.004562767 | 0.451989691 | 1.552573077 | 0.00511 | 0.012236077 |
| LUAD | 3.597077091 | 5.005887436 | -1.408810345 | 0.00642 | 0.011960183 |
| KIRC | -1.817430715 | -0.130836271 | -1.686594444 | 0.000195 | 0.000399447 |
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| TissGene-miRNA for MSLN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MSLN |
| TissGeneSNV for MSLN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M601V | PCPG | 3 |
| p.M601V | UVM | 2 |
| p.S498F | SKCM | 2 |
| p.G213E | SKCM | 1 |
| p.P409H | COAD | 1 |
| p.K428N | LUAD | 1 |
| p.Q370X | SKCM | 1 |
| p.E158V | LUAD | 1 |
| p.P128L | LUAD | 1 |
| p.R413Q | COAD | 1 |
| p.A6G | LIHC | 1 |
| p.G50E | SKCM | 1 |
| p.A72V | BRCA | 1 |
| p.W240L | LIHC | 1 |
| p.G605A | BLCA | 1 |
| p.S276F | LUSC | 1 |
| p.G50R | BRCA | 1 |
| p.R282Q | ACC | 1 |
| p.L10S | SKCM | 1 |
| p.V254M | LUAD | 1 |
| p.V612I | PRAD | 1 |
| p.R107Q | BLCA | 1 |
| p.S276F | DLBC | 1 |
| p.E499K | GBM | 1 |
| p.P412A | BLCA | 1 |
| p.P56A | BLCA | 1 |
| p.Q257H | DLBC | 1 |
| p.L323P | STAD | 1 |
| p.D116G | PRAD | 1 |
| p.R385H | STAD | 1 |
| p.N496D | DLBC | 1 |
| p.G489E | COAD | 1 |
| p.S280Y | COAD | 1 |
| p.L625I | LIHC | 1 |
| p.E393D | UCEC | 1 |
| p.R385H | DLBC | 1 |
| p.K420N | LUAD | 1 |
| p.L67F | LUSC | 1 |
| p.R309C | STAD | 1 |
| p.P253L | SKCM | 1 |
| p.V475I | SKCM | 1 |
| p.L104V | LUAD | 1 |
| p.A435T | SARC | 1 |
| p.A38V | LIHC | 1 |
| p.S109C | CESC | 1 |
| p.S443Y | COAD | 1 |
| p.R286Q | SKCM | 1 |
| p.R471K | SKCM | 1 |
| p.E400Q | HNSC | 1 |
| p.A529S | UCEC | 1 |
| p.R7Q | READ | 1 |
| p.M601V | BRCA | 1 |
| p.R274C | LGG | 1 |
| p.S20I | LGG | 1 |
| p.G256A | STAD | 1 |
| p.V524M | STAD | 1 |
| p.T15I | SKCM | 1 |
| p.S238L | STAD | 1 |
| p.M532I | LUAD | 1 |
| p.D191N | COAD | 1 |
| p.D114V | LUAD | 1 |
| p.G231E | HNSC | 1 |
| p.R295W | COAD | 1 |
| p.P212L | HNSC | 1 |
| p.G599E | SKCM | 1 |
| p.Q370* | SKCM | 1 |
| p.A156S | LUSC | 1 |
| p.M593V | COAD | 1 |
| p.R294L | LIHC | 1 |
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| TissGeneCNV for MSLN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MSLN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for MSLN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| COAD (tumor) | COAD (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| KICH (tumor) | KICH (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| STAD (tumor) | STAD (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| THCA (tumor) | THCA (normal) |
| MSLN, MUC16 (tumor) | MSLN, MUC16 (normal) |
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| TissGeneProg for MSLN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MSLN |
| TissGeneDrug for MSLN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MSLN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025500 | Mesothelioma | 31 | BeFree,CTD_human,LHGDN,RGD |
| umls:C0029925 | Ovarian Carcinoma | 19 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 16 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 15 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 15 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 8 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 6 | BeFree,LHGDN |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 6 | BeFree |
| umls:C0001418 | Adenocarcinoma | 5 | BeFree,CTD_human,LHGDN |
| umls:C0030297 | Pancreatic Neoplasm | 5 | BeFree,CTD_human,LHGDN |
| umls:C0281361 | Adenocarcinoma of pancreas | 5 | BeFree |
| umls:C0919267 | ovarian neoplasm | 5 | BeFree,CTD_human,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree |
| umls:C0345967 | Malignant mesothelioma | 4 | BeFree |
| umls:C0887833 | Carcinoma, Pancreatic Ductal | 4 | CTD_human,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0178874 | Tumor Progression | 3 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 3 | BeFree,CTD_human |
| umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree,LHGDN |
| umls:C0206701 | Cystadenocarcinoma, Serous | 2 | BeFree |
| umls:C0346976 | Secondary malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C1519680 | Tumor Immunity | 2 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 2 | BeFree |
| umls:C3714739 | Mesothelial Neoplasms | 2 | CTD_human |
| umls:C0003537 | Aphasia | 1 | LHGDN |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
| umls:C0012546 | Diphtheria | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree,LHGDN |
| umls:C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| umls:C0025286 | Meningioma | 1 | LHGDN |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0153453 | Malignant tumor of extrahepatic bile duct | 1 | BeFree |
| umls:C0205698 | Undifferentiated carcinoma | 1 | BeFree |
| umls:C0206687 | Carcinoma, Endometrioid | 1 | CTD_human |
| umls:C0238019 | Carcinoma of extrahepatic bile duct | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0334309 | Adenocarcinoma in tubulovillous adenoma | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0861727 | Pancreatic adenocarcinoma metastatic | 1 | BeFree |
| umls:C1335177 | Ovarian Serous Adenocarcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
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