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| TissGeneSummary for LRRC17 |
 Gene summary |
| Basic gene information | Gene symbol | LRRC17 |
| Gene name | leucine rich repeat containing 17 | |
| Synonyms | P37NB | |
| Cytomap | UCSC genome browser: 7q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001031692.2, NM_005824.2, | |
| Description | 37 kDa leucine-rich repeat (LRR) proteinleucine-rich repeat-containing protein 17 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000128606 | ||
| HPRD : 10059 | ||
| Vega : OTTHUMG00000157210 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LRRC17 | |
| BioGPS: 10234 | ||
| Pathway | NCI Pathway Interaction Database: LRRC17 | |
| KEGG: LRRC17 | ||
| REACTOME: LRRC17 | ||
| Pathway Commons: LRRC17 | ||
| Context | iHOP: LRRC17 | |
| ligand binding site mutation search in PubMed: LRRC17 | ||
| UCL Cancer Institute: LRRC17 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
| Reference showing the relevant tissue of LRRC17 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LRRC17 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.090804298 | -0.965987369 | 1.056791667 | 3.83E-11 | 1.42E-10 |
| PRAD | -1.488428929 | -0.246938544 | -1.241490385 | 7.36E-10 | 1.24E-08 |
| ESCA | -1.997010222 | 0.802571596 | -2.799581818 | 0.00459 | 0.037668487 |
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| TissGene-miRNA for LRRC17 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LRRC17 |
| TissGeneSNV for LRRC17 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E214D | LIHC | 2 |
| p.E287K | SKCM | 2 |
| p.K199N | COAD | 1 |
| p.T173M | HNSC | 1 |
| p.H425R | BLCA | 1 |
| p.L135F | LUAD | 1 |
| p.E123V | LUAD | 1 |
| p.L155F | PRAD | 1 |
| p.V237A | SARC | 1 |
| p.D253N | SKCM | 1 |
| p.H292Q | SKCM | 1 |
| p.E216K | ESCA | 1 |
| p.V335L | SKCM | 1 |
| p.A190S | STAD | 1 |
| p.P231S | SKCM | 1 |
| p.L344R | SKCM | 1 |
| p.M177L | LGG | 1 |
| p.N330S | COAD | 1 |
| p.N244S | UCEC | 1 |
| p.V435I | PAAD | 1 |
| p.N326S | LIHC | 1 |
| p.K295N | UCEC | 1 |
| p.G51D | BLCA | 1 |
| p.E216K | LIHC | 1 |
| p.P381A | LUSC | 1 |
| p.I437T | BLCA | 1 |
| p.D82N | SKCM | 1 |
| p.S194T | STAD | 1 |
| p.C378G | SARC | 1 |
| p.E214D | KIRC | 1 |
| p.I141M | THCA | 1 |
| p.K402Q | READ | 1 |
| p.P248S | STAD | 1 |
| p.F125L | BLCA | 1 |
| p.H359R | BLCA | 1 |
| p.T316I | UCEC | 1 |
| p.K191E | BLCA | 1 |
| p.H61N | STAD | 1 |
| p.R426G | LUSC | 1 |
| p.A311T | STAD | 1 |
| p.L134F | SKCM | 1 |
| p.A310V | SKCM | 1 |
| p.A407T | KIRP | 1 |
| p.R2H | LGG | 1 |
| p.D418Y | UCEC | 1 |
| p.A21T | COAD | 1 |
| p.P222L | STAD | 1 |
| p.F306C | LUAD | 1 |
| p.Y277S | UCEC | 1 |
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| TissGeneCNV for LRRC17 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LRRC17 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LRRC17 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for LRRC17 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LRRC17 |
| TissGeneDrug for LRRC17 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LRRC17 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0026499 | Monosomy | 1 | BeFree |
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