TissGeneSummary for B3GNT3 |
Gene summary |
Basic gene information | Gene symbol | B3GNT3 |
Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | |
Synonyms | B3GAL-T8|B3GN-T3|B3GNT-3|HP10328|TMEM3|beta3Gn-T3 | |
Cytomap | UCSC genome browser: 19p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_014256.3, | |
Description | UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8beta-1,3-GalTase 8beta-1,3-Gn-T3beta-1,3-N-acetylglucosaminyltransferase bGnT-3beta-3-Gx-T8beta3GalT8core 1 extending beta-1, | |
Modification date | 20141207 | |
dbXrefs | MIM : 605863 | |
HGNC : HGNC | ||
Ensembl : ENSG00000179913 | ||
HPRD : 10431 | ||
Vega : OTTHUMG00000183490 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_B3GNT3 | |
BioGPS: 10331 | ||
Pathway | NCI Pathway Interaction Database: B3GNT3 | |
KEGG: B3GNT3 | ||
REACTOME: B3GNT3 | ||
Pathway Commons: B3GNT3 | ||
Context | iHOP: B3GNT3 | |
ligand binding site mutation search in PubMed: B3GNT3 | ||
UCL Cancer Institute: B3GNT3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSTAD | |
Reference showing the relevant tissue of B3GNT3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0030311 | poly-N-acetyllactosamine biosynthetic process | 11042166 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process | 11042166 |
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TissGeneExp for B3GNT3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 3.394365912 | -0.781194433 | 4.175560345 | 1.33E-28 | 9.94E-27 |
BRCA | -0.522312521 | 0.936370812 | -1.458683333 | 1.60E-06 | 4.27E-06 |
THCA | 2.390457788 | -2.763243907 | 5.153701695 | 1.57E-18 | 4.24E-17 |
KICH | -4.286485398 | 2.330894602 | -6.61738 | 3.07E-20 | 2.42E-18 |
LUSC | 1.185872876 | -0.715825163 | 1.901698039 | 5.03E-07 | 1.31E-06 |
STAD | 5.433377227 | 3.835820977 | 1.59755625 | 0.00979 | 0.033977948 |
PRAD | -0.613378783 | 0.832390448 | -1.445769231 | 6.32E-05 | 0.000278802 |
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TissGene-miRNA for B3GNT3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for B3GNT3 |
TissGeneSNV for B3GNT3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D356N | HNSC | 1 |
p.E307K | COAD | 1 |
p.A247V | SKCM | 1 |
p.I245T | STAD | 1 |
p.A286P | PRAD | 1 |
p.A203T | UCEC | 1 |
p.V235M | UCEC | 1 |
p.L306F | UCEC | 1 |
p.E256Q | BRCA | 1 |
p.R123H | LUSC | 1 |
p.S330F | SKCM | 1 |
p.G148D | PAAD | 1 |
p.R122C | HNSC | 1 |
p.P294T | LGG | 1 |
p.G171R | STAD | 1 |
p.C200G | BLCA | 1 |
p.P93L | SKCM | 1 |
p.R122C | UCEC | 1 |
p.P244S | SKCM | 1 |
p.G366D | SKCM | 1 |
p.Q96* | HNSC | 1 |
p.G301S | SKCM | 1 |
p.W249* | HNSC | 1 |
p.E305* | LUAD | 1 |
p.A19T | THYM | 1 |
p.F205L | STAD | 1 |
p.G366S | SKCM | 1 |
p.R263Q | STAD | 1 |
p.E166* | BLCA | 1 |
p.R122H | STAD | 1 |
p.E305Q | LUAD | 1 |
p.R90C | LUSC | 1 |
p.D210N | SKCM | 1 |
p.F222V | READ | 1 |
p.E262K | LUAD | 1 |
p.W195L | UCEC | 1 |
p.D297N | SKCM | 1 |
p.A281T | LUSC | 1 |
p.G171R | GBM | 1 |
p.P244S | LUAD | 1 |
p.R263W | COAD | 1 |
p.P60L | PRAD | 1 |
p.R8P | LUSC | 1 |
p.P117S | HNSC | 1 |
p.V298A | GBM | 1 |
p.S276F | LUAD | 1 |
p.G308R | SKCM | 1 |
p.F293L | LUAD | 1 |
p.D333Y | THCA | 1 |
p.A104V | PRAD | 1 |
p.A42T | SKCM | 1 |
p.E45V | LGG | 1 |
p.R338Q | SKCM | 1 |
p.S181C | CESC | 1 |
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TissGeneCNV for B3GNT3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for B3GNT3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCEC | TCGA-D1-A3JP-01A | B3GNT3-INSL3 | 5'UTR-CDS | chr19:17906015 | chr19:17927868 |
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TissGeneNet for B3GNT3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for B3GNT3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for B3GNT3 |
TissGeneDrug for B3GNT3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for B3GNT3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021400 | Influenza | 3 | BeFree |
umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
umls:C0021368 | Inflammation | 1 | GAD |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |