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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CCL26
check button Gene summary
Basic gene informationGene symbolCCL26
Gene namechemokine (C-C motif) ligand 26
SynonymsIMAC|MIP-4a|MIP-4alpha|SCYA26|TSC-1
CytomapUCSC genome browser: 7q11.23
Type of geneprotein-coding
RefGenesNM_006072.4,
DescriptionC-C motif chemokine 26CC chemokine IMACMIP-4-alphachemokine N1eotaxin-3macrophage inflammatory protein 4-alphasmall inducible cytokine A26small inducible cytokine subfamily A (Cys-Cys), member 26small-inducible cytokine A26thymic stroma chemokine
Modification date20141207
dbXrefs MIM : 604697
HGNC : HGNC
Ensembl : ENSG00000006606
HPRD : 05262
Vega : OTTHUMG00000130403
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CCL26
BioGPS: 10344
PathwayNCI Pathway Interaction Database: CCL26
KEGG: CCL26
REACTOME: CCL26
Pathway Commons: CCL26
ContextiHOP: CCL26
ligand binding site mutation search in PubMed: CCL26
UCL Cancer Institute: CCL26
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)OvaryEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)OVUVM
Reference showing the relevant tissue of CCL26
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001938positive regulation of endothelial cell proliferation19525930
GO:0030335positive regulation of cell migration19525930
GO:0030838positive regulation of actin filament polymerization19525930
GO:0032855positive regulation of Rac GTPase activity19525930
GO:0001938positive regulation of endothelial cell proliferation19525930
GO:0030335positive regulation of cell migration19525930
GO:0030838positive regulation of actin filament polymerization19525930
GO:0032855positive regulation of Rac GTPase activity19525930


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TissGeneExp for CCL26

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC1.503343187-0.9271332832.4304764716.60E-122.81E-11
LUAD0.170137609-1.094033081.264170695.09E-061.54E-05
THCA-0.691376155-1.8374981881.1461220342.87E-081.34E-07
KICH-2.14314246-0.43944646-1.7036962.51E-081.25E-07
HNSC1.6305999590.6294464711.0011534880.01010.024972527
COAD0.568910156-0.9552475371.5241576920.0004560.001421189
LIHC-1.13737846-2.189846461.0524680.0002060.000656422


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TissGene-miRNA for CCL26

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CCL26
TissGeneSNV for CCL26

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E51KSKCM1
p.R48XPAAD1
p.K83*SKCM1
p.L94VCOAD1
p.L42FBLCA1
p.A61VLGG1
p.L12MCOAD1
p.R77KLGG1
p.R48*PAAD1
p.T53SLUSC1


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TissGeneCNV for CCL26

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CCL26

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CCL26

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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COAD (tumor)COAD (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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HNSC (tumor)HNSC (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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KICH (tumor)KICH (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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KIRC (tumor)KIRC (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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KIRP (tumor)KIRP (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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LIHC (tumor)LIHC (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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LUAD (tumor)LUAD (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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LUSC (tumor)LUSC (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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PRAD (tumor)PRAD (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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STAD (tumor)STAD (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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THCA (tumor)THCA (normal)
CCL26, CCR1, CCR3, DYNC2LI1 (tumor)CCL26, CCR1, CCR3, DYNC2LI1 (normal)
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TissGeneProg for CCL26

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CCL26
TissGeneDrug for CCL26

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CCL26

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0004096Asthma15BeFree,GAD
umls:C0341106Eosinophilic esophagitis9BeFree,CTD_human
umls:C0014457Eosinophilia6BeFree
umls:C1306759Eosinophilic disorder6BeFree
umls:C1636667Disorder characterized by eosinophilia6BeFree
umls:C0009324Ulcerative Colitis3BeFree,GAD,LHGDN
umls:C0003873Rheumatoid Arthritis2BeFree,GAD
umls:C0011603Dermatitis2BeFree
umls:C0011615Dermatitis, Atopic2BeFree
umls:C0013595Eczema2BeFree
umls:C0014868Esophagitis2LHGDN
umls:C0017168Gastroesophageal reflux disease2BeFree,LHGDN
umls:C0021390Inflammatory Bowel Diseases2BeFree,LHGDN
umls:C0027430Nasal Polyps2BeFree
umls:C0041341Tuberous Sclerosis2BeFree
umls:C0149516Chronic sinusitis2BeFree
umls:C0699949airway disease2BeFree
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0008728Churg-Strauss Syndrome1BeFree
umls:C0011168Deglutition Disorders1BeFree
umls:C0019693HIV Infections1GAD
umls:C0021368Inflammation1LHGDN
umls:C0024899Mastocytosis1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0035235Respiratory Syncytial Virus Infections1GAD
umls:C0036429Sclerosis1LHGDN
umls:C0042111Urticaria Pigmentosa1BeFree
umls:C0042384Vasculitis1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0155877Allergic asthma1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0877430Asthma chronic1BeFree
umls:C2985318Pregnancy Related Skin Change1BeFree
umls:C3714514Infection1LHGDN