TissGeneSummary for ABCA10 |
Gene summary |
Basic gene information | Gene symbol | ABCA10 |
Gene name | ATP-binding cassette, sub-family A (ABC1), member 10 | |
Synonyms | EST698739 | |
Cytomap | UCSC genome browser: 17q24 | |
Type of gene | protein-coding | |
RefGenes | NM_080282.3, | |
Description | ATP-binding cassette A10ATP-binding cassette sub-family A member 10 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612508 | |
HGNC : HGNC | ||
Ensembl : ENSG00000154263 | ||
HPRD : 12400 | ||
Vega : OTTHUMG00000164716 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ABCA10 | |
BioGPS: 10349 | ||
Pathway | NCI Pathway Interaction Database: ABCA10 | |
KEGG: ABCA10 | ||
REACTOME: ABCA10 | ||
Pathway Commons: ABCA10 | ||
Context | iHOP: ABCA10 | |
ligand binding site mutation search in PubMed: ABCA10 | ||
UCL Cancer Institute: ABCA10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
Reference showing the relevant tissue of ABCA10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ABCA10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.086235526 | 3.592208334 | -4.67844386 | 4.38E-55 | 9.87E-53 |
KIRP | -1.977240406 | -0.484587281 | -1.492653125 | 1.94E-06 | 9.18E-06 |
COAD | -1.092344973 | 0.518947335 | -1.611292308 | 1.28E-06 | 7.08E-06 |
THCA | -0.922365247 | 0.981053397 | -1.903418644 | 4.64E-15 | 5.97E-14 |
LUSC | -1.089230418 | 1.042024484 | -2.131254902 | 5.53E-12 | 2.38E-11 |
LUAD | -1.575370039 | 0.708035133 | -2.283405172 | 1.48E-18 | 2.18E-17 |
LIHC | -0.240301281 | 1.194468719 | -1.43477 | 4.40E-06 | 2.04E-05 |
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TissGene-miRNA for ABCA10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ABCA10 |
TissGeneSNV for ABCA10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S747G | ESCA | 2 |
p.L1504P | ESCA | 2 |
p.R923C | SKCM | 2 |
p.K888N | UCEC | 2 |
p.S444F | ESCA | 2 |
p.T911M | STAD | 2 |
p.D847Y | UCEC | 2 |
p.Y217C | LIHC | 1 |
p.D1096V | COAD | 1 |
p.G170S | STAD | 1 |
p.E1404K | BRCA | 1 |
p.S609L | SKCM | 1 |
p.T821M | GBM | 1 |
p.R1433T | BLCA | 1 |
p.P1539T | ESCA | 1 |
p.K161Q | UCEC | 1 |
p.P265L | SKCM | 1 |
p.Y1000F | LUAD | 1 |
p.N429T | LUAD | 1 |
p.E1011G | UCEC | 1 |
p.K1528N | COAD | 1 |
p.V168E | LUSC | 1 |
p.N891K | SKCM | 1 |
p.E791X | COAD | 1 |
p.R627K | UCEC | 1 |
p.P300S | SKCM | 1 |
p.E1373K | CESC | 1 |
p.G160* | PAAD | 1 |
p.K844T | READ | 1 |
p.E1300D | STAD | 1 |
p.V691L | LUAD | 1 |
p.A1411T | COAD | 1 |
p.S377Y | SKCM | 1 |
p.L736I | UCEC | 1 |
p.I287V | COAD | 1 |
p.E101* | UCEC | 1 |
p.E1402D | LUAD | 1 |
p.S610F | SKCM | 1 |
p.F1282L | UCEC | 1 |
p.F1006L | KIRP | 1 |
p.D1527N | BLCA | 1 |
p.A884E | LUAD | 1 |
p.G620* | LUAD | 1 |
p.S192P | STAD | 1 |
p.G129V | LUAD | 1 |
p.1063_1064MV>IL | LUAD | 1 |
p.E1172K | SKCM | 1 |
p.S350C | LUAD | 1 |
p.G1005X | STAD | 1 |
p.L751I | STAD | 1 |
p.G432A | LUSC | 1 |
p.L930F | OV | 1 |
p.L1136V | HNSC | 1 |
p.H1301D | COAD | 1 |
p.G1005* | STAD | 1 |
p.E588G | COAD | 1 |
p.M1077T | STAD | 1 |
p.R510I | UCEC | 1 |
p.F1050L | LUAD | 1 |
p.G1046D | UCEC | 1 |
p.P1543S | PAAD | 1 |
p.Q682H | LUAD | 1 |
p.I720M | STAD | 1 |
p.C945* | LUAD | 1 |
p.F561S | SKCM | 1 |
p.V1386I | GBM | 1 |
p.S1353R | THYM | 1 |
p.K668T | STAD | 1 |
p.R1223I | COAD | 1 |
p.I636M | BLCA | 1 |
p.S201X | CHOL | 1 |
p.R763C | UCEC | 1 |
p.A71V | ESCA | 1 |
p.R332X | STAD | 1 |
p.K60N | COAD | 1 |
p.M1298V | LUAD | 1 |
p.S865F | SKCM | 1 |
p.D1434N | UCEC | 1 |
p.Q1125E | LUAD | 1 |
p.Q457* | BRCA | 1 |
p.A1326V | LUAD | 1 |
p.A226E | LUAD | 1 |
p.A1492V | SKCM | 1 |
p.I1121V | ESCA | 1 |
p.G341R | HNSC | 1 |
p.Q1520K | LUSC | 1 |
p.E101X | READ | 1 |
p.S705X | PAAD | 1 |
p.I453F | LIHC | 1 |
p.F910L | DLBC | 1 |
p.T1496N | KIRC | 1 |
p.E1325K | SKCM | 1 |
p.I368V | LUSC | 1 |
p.E448K | LUAD | 1 |
p.R769C | COAD | 1 |
p.E1519D | LUSC | 1 |
p.R534I | UCEC | 1 |
p.G160X | PAAD | 1 |
p.F669L | CESC | 1 |
p.E371D | LUAD | 1 |
p.D342N | READ | 1 |
p.A97T | COAD | 1 |
p.F385S | LUAD | 1 |
p.E488* | UCEC | 1 |
p.K349N | STAD | 1 |
p.P894S | SKCM | 1 |
p.M586V | UCEC | 1 |
p.S1469C | LUSC | 1 |
p.M132I | SARC | 1 |
p.Y79H | HNSC | 1 |
p.E1166V | BLCA | 1 |
p.G181* | GBM | 1 |
p.S232R | BRCA | 1 |
p.L592F | KIRC | 1 |
p.T1368I | SKCM | 1 |
p.L941F | CESC | 1 |
p.D925Y | READ | 1 |
p.G1422V | COAD | 1 |
p.L1265S | UCEC | 1 |
p.P370S | SKCM | 1 |
p.R332* | STAD | 1 |
p.L1514X | SKCM | 1 |
p.G1005* | LUAD | 1 |
p.R510I | COAD | 1 |
p.E365D | ESCA | 1 |
p.K1347N | READ | 1 |
p.D708E | LUSC | 1 |
p.T1114I | LUAD | 1 |
p.E488X | READ | 1 |
p.F493Y | KIRC | 1 |
p.P864S | SKCM | 1 |
p.K1231T | UCEC | 1 |
p.I467V | BRCA | 1 |
p.V381L | LUAD | 1 |
p.R880I | STAD | 1 |
p.K1113T | OV | 1 |
p.D1434N | COAD | 1 |
p.Q682L | LUAD | 1 |
p.G530C | HNSC | 1 |
p.D853N | LUAD | 1 |
p.Q480* | SKCM | 1 |
p.S834* | BLCA | 1 |
p.N1142K | READ | 1 |
p.A494D | BLCA | 1 |
p.E1193* | LUAD | 1 |
p.Q480X | SKCM | 1 |
p.W967R | KIRP | 1 |
p.K31R | SKCM | 1 |
p.E465K | COAD | 1 |
p.F764Y | LIHC | 1 |
p.D1102Y | LUSC | 1 |
p.E1500D | STAD | 1 |
p.L1514* | SKCM | 1 |
p.K668T | UCEC | 1 |
p.K792N | UCEC | 1 |
p.E34K | LUAD | 1 |
p.P1162T | LUSC | 1 |
p.E1192K | HNSC | 1 |
p.F144L | UCEC | 1 |
p.N119K | SKCM | 1 |
p.A1472V | KIRP | 1 |
p.V445L | THYM | 1 |
p.S444F | LIHC | 1 |
p.Y149X | READ | 1 |
p.K1147T | READ | 1 |
p.F585L | LGG | 1 |
p.R769S | UCEC | 1 |
p.M586V | LIHC | 1 |
p.P1372L | SKCM | 1 |
p.W252X | STAD | 1 |
p.S1226F | SKCM | 1 |
p.G951D | HNSC | 1 |
p.N369T | SKCM | 1 |
p.P1444L | LUAD | 1 |
p.I1037S | COAD | 1 |
p.R332* | LIHC | 1 |
p.W752* | BRCA | 1 |
p.R1409L | STAD | 1 |
p.V1064L | LUAD | 1 |
p.E1342K | SKCM | 1 |
p.S343F | HNSC | 1 |
p.E1168K | STAD | 1 |
p.S638F | SKCM | 1 |
p.V597L | BRCA | 1 |
p.D301H | COAD | 1 |
p.R768M | OV | 1 |
p.G412S | ESCA | 1 |
p.M231I | CESC | 1 |
p.G256E | SKCM | 1 |
p.P29L | SKCM | 1 |
p.L1116V | HNSC | 1 |
p.G76* | LUAD | 1 |
p.E1373K | SKCM | 1 |
p.E130* | UCEC | 1 |
p.G430V | LUAD | 1 |
p.E1443K | UCEC | 1 |
p.R1409C | LUAD | 1 |
p.E1515* | UCEC | 1 |
p.E1011K | UCEC | 1 |
p.H340N | LUAD | 1 |
p.D1171H | BLCA | 1 |
p.D878N | KIRC | 1 |
p.T1339I | UCEC | 1 |
p.R615Q | GBM | 1 |
p.E696* | HNSC | 1 |
p.L538Q | SKCM | 1 |
p.M1063I | LUAD | 1 |
p.T651K | UCEC | 1 |
p.R332X | LIHC | 1 |
p.R763C | SKCM | 1 |
p.G242A | STAD | 1 |
p.D863Y | LUAD | 1 |
p.C606Y | LUAD | 1 |
p.K960R | LAML | 1 |
p.P29S | SKCM | 1 |
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TissGeneCNV for ABCA10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ABCA10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BLCA | TCGA-BT-A2LA-01A | HELZ-ABCA10 | 5UTR-5UTR | Chr17:65239900 | Chr17:67223426 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A6IW-01A | BRWD1-ABCA10 | Out-of-frame | Chr21:40619627 | Chr17:67184020 |
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TissGeneNet for ABCA10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ABCA10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ABCA10 |
TissGeneDrug for ABCA10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ABCA10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009404 | Colorectal Neoplasms | 1 | CTD_human |