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| TissGeneSummary for CACNG3 |
 Gene summary |
| Basic gene information | Gene symbol | CACNG3 |
| Gene name | calcium channel, voltage-dependent, gamma subunit 3 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 16p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006539.3, | |
| Description | TARP gamma-3neuronal voltage-gated calcium channel gamma-3 subunittransmembrane AMPAR regulatory protein gamma-3voltage-dependent calcium channel gamma-3 subunitvoltage-gated calcium channel gamma subunit | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606403 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000006116 | ||
| HPRD : 05910 | ||
| Vega : OTTHUMG00000131651 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CACNG3 | |
| BioGPS: 10368 | ||
| Pathway | NCI Pathway Interaction Database: CACNG3 | |
| KEGG: CACNG3 | ||
| REACTOME: CACNG3 | ||
| Pathway Commons: CACNG3 | ||
| Context | iHOP: CACNG3 | |
| ligand binding site mutation search in PubMed: CACNG3 | ||
| UCL Cancer Institute: CACNG3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of CACNG3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CACNG3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CACNG3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CACNG3 |
| TissGeneSNV for CACNG3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P314L | SKCM | 2 |
| p.R208Q | SKCM | 2 |
| p.G277E | SKCM | 2 |
| p.S211F | SKCM | 2 |
| p.S268F | SKCM | 2 |
| p.R230* | SKCM | 1 |
| p.G182R | STAD | 1 |
| p.D163N | BLCA | 1 |
| p.D81N | UCS | 1 |
| p.S235L | SKCM | 1 |
| p.Y175C | LUAD | 1 |
| p.E49K | KIRC | 1 |
| p.R99Q | SKCM | 1 |
| p.R230X | SKCM | 1 |
| p.R284W | SARC | 1 |
| p.R245Q | SKCM | 1 |
| p.P258S | SKCM | 1 |
| p.S237P | LUSC | 1 |
| p.Q91E | HNSC | 1 |
| p.N48S | UCEC | 1 |
| p.R230Q | STAD | 1 |
| p.A138T | COAD | 1 |
| p.F221S | UCEC | 1 |
| p.A161S | LUAD | 1 |
| p.R208Q | PAAD | 1 |
| p.R232W | SKCM | 1 |
| p.G182R | LGG | 1 |
| p.K78N | LUSC | 1 |
| p.C67* | LUAD | 1 |
| p.R167C | STAD | 1 |
| p.R234Q | LUAD | 1 |
| p.E301K | SKCM | 1 |
| p.V315I | LGG | 1 |
| p.P258L | SKCM | 1 |
| p.Y229N | OV | 1 |
| p.A161T | READ | 1 |
| p.V197M | SARC | 1 |
| p.R99Q | LUAD | 1 |
| p.E241K | SKCM | 1 |
| p.R311H | LUSC | 1 |
| p.Q166K | BRCA | 1 |
| p.R167C | ESCA | 1 |
| p.T113M | BRCA | 1 |
| p.G71R | SKCM | 1 |
| p.D47Y | LUAD | 1 |
| p.L207V | UCEC | 1 |
| p.N149I | LUAD | 1 |
| p.P164H | LUAD | 1 |
| p.E190K | SKCM | 1 |
| p.A138T | GBM | 1 |
| p.G277R | OV | 1 |
| p.L280F | SKCM | 1 |
| p.E241K | ESCA | 1 |
| p.E95K | SKCM | 1 |
| p.R102W | HNSC | 1 |
| p.K217N | READ | 1 |
| p.S44C | LUAD | 1 |
| p.R228K | SKCM | 1 |
| p.H292Y | SKCM | 1 |
| p.A20T | UCEC | 1 |
| p.S248P | STAD | 1 |
| p.A159S | SKCM | 1 |
| p.K210T | STAD | 1 |
| p.R208* | GBM | 1 |
| p.L289Q | LIHC | 1 |
| p.R243K | SKCM | 1 |
| p.R230* | BLCA | 1 |
| p.D88Y | LUAD | 1 |
| p.L136I | COAD | 1 |
| p.T93K | STAD | 1 |
| p.R99* | LUAD | 1 |
| p.M264I | SKCM | 1 |
| p.S239Y | LGG | 1 |
| p.N149D | UCEC | 1 |
| p.E49K | SKCM | 1 |
| p.R311C | LGG | 1 |
| p.H82D | BLCA | 1 |
| p.A145T | UCEC | 1 |
| p.V315I | UCEC | 1 |
| p.H255Y | SKCM | 1 |
| p.T30K | LUAD | 1 |
| p.R245* | UCEC | 1 |
| p.Q91H | UCEC | 1 |
| p.A222S | BLCA | 1 |
| p.S169T | HNSC | 1 |
| p.D270N | LUAD | 1 |
| p.L136F | LUAD | 1 |
| p.E90K | SKCM | 1 |
| p.A138T | PAAD | 1 |
| p.D47G | COAD | 1 |
| p.N133S | LUAD | 1 |
| p.V28M | UCEC | 1 |
| p.S259F | SKCM | 1 |
| p.E95K | READ | 1 |
| p.G16E | SKCM | 1 |
| p.C67S | LUAD | 1 |
| p.L97I | READ | 1 |
| p.S213L | BRCA | 1 |
| p.R311P | LUSC | 1 |
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| TissGeneCNV for CACNG3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CACNG3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CACNG3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CACNG3, AP4M1 (tumor) | CACNG3, AP4M1 (normal) |
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| TissGeneProg for CACNG3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CACNG3 |
| TissGeneDrug for CACNG3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CACNG3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014544 | Epilepsy | 1 | GAD |
| umls:C0014553 | Absence Epilepsy | 1 | BeFree |
| umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C1868682 | Paroxysmal kinesigenic choreoathetosis | 1 | BeFree |
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