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| TissGeneSummary for CACNG2 |
 Gene summary |
| Basic gene information | Gene symbol | CACNG2 |
| Gene name | calcium channel, voltage-dependent, gamma subunit 2 | |
| Synonyms | MRD10 | |
| Cytomap | UCSC genome browser: 22q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006078.3, | |
| Description | TARP gamma-2neuronal voltage-gated calcium channel gamma-2 subunitstargazintransmembrane AMPAR regulatory protein gamma-2voltage-dependent calcium channel gamma-2 subunit | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602911 | |
| HGNC : HGNC | ||
| HPRD : 04220 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CACNG2 | |
| BioGPS: 10369 | ||
| Pathway | NCI Pathway Interaction Database: CACNG2 | |
| KEGG: CACNG2 | ||
| REACTOME: CACNG2 | ||
| Pathway Commons: CACNG2 | ||
| Context | iHOP: CACNG2 | |
| ligand binding site mutation search in PubMed: CACNG2 | ||
| UCL Cancer Institute: CACNG2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGLUAD,LUSC | |
| Reference showing the relevant tissue of CACNG2 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CACNG2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CACNG2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CACNG2 |
| TissGeneSNV for CACNG2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R292K | SKCM | 1 |
| p.R204Q | COAD | 1 |
| p.E49K | LUAD | 1 |
| p.W33S | KIRP | 1 |
| p.A159T | OV | 1 |
| p.R6P | HNSC | 1 |
| p.A161S | ESCA | 1 |
| p.E55K | PAAD | 1 |
| p.S241L | SKCM | 1 |
| p.G71R | LUAD | 1 |
| p.V57I | LAML | 1 |
| p.A190V | SKCM | 1 |
| p.L76M | LGG | 1 |
| p.Y174C | STAD | 1 |
| p.G139A | UCEC | 1 |
| p.M58I | BLCA | 1 |
| p.R318C | STAD | 1 |
| p.M1I | SKCM | 1 |
| p.G162E | SKCM | 1 |
| p.R213H | COAD | 1 |
| p.L76M | UCEC | 1 |
| p.G62* | ESCA | 1 |
| p.V193A | LIHC | 1 |
| p.Q207L | LIHC | 1 |
| p.R242H | STAD | 1 |
| p.G162R | SKCM | 1 |
| p.L311H | LUSC | 1 |
| p.A281D | THYM | 1 |
| p.T14N | KIRP | 1 |
| p.S274N | SKCM | 1 |
| p.A103V | HNSC | 1 |
| p.V15I | BLCA | 1 |
| p.S36T | LIHC | 1 |
| p.N133Y | BLCA | 1 |
| p.G16S | LUAD | 1 |
| p.A91V | SKCM | 1 |
| p.R235C | UCEC | 1 |
| p.S249F | SKCM | 1 |
| p.E90K | SKCM | 1 |
| p.V255M | HNSC | 1 |
| p.S137N | SKCM | 1 |
| p.G62V | LUAD | 1 |
| p.R131X | READ | 1 |
| p.E55K | SKCM | 1 |
| p.E85K | BRCA | 1 |
| p.K78N | LIHC | 1 |
| p.G256S | SKCM | 1 |
| p.K78M | LIHC | 1 |
| p.W64X | SKCM | 1 |
| p.R99W | COAD | 1 |
| p.C67F | SKCM | 1 |
| p.R209W | PAAD | 1 |
| p.W64* | SKCM | 1 |
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| TissGeneCNV for CACNG2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CACNG2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-A2-A0YM-01A | MYH9-CACNG2 | Out-of-Frame | chr22:36722612 | chr22:36962540 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0BW-01A | MYH9-CACNG2 | 5'UTR-CDS | chr22:36783851 | chr22:36962540 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-A4SS-01A | MYH9-CACNG2 | 5'UTR-CDS | chr22:36783851 | chr22:36983595 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A0BW-11A | MYH9-CACNG2 | 5'UTR-CDS | chr22:36783851 | chr22:36962539 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A0BW-01A | MYH9-CACNG2 | 5'UTR-CDS | chr22:36783851 | chr22:36962539 |
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| TissGeneNet for CACNG2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| COAD (tumor) | COAD (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| KICH (tumor) | KICH (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| STAD (tumor) | STAD (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| THCA (tumor) | THCA (normal) |
| CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (tumor) | CACNG2, DLG2, PRKACA, DLG4, GRIN1, GRIA4, INADL, DLG1, DLG3, GRIA1, GRIA2 (normal) |
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| TissGeneProg for CACNG2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CACNG2 |
| TissGeneDrug for CACNG2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00898 | Ethanol | Small molecule | Approved |
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| TissGeneDisease for CACNG2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 4 | BeFree,GAD |
| umls:C0242596 | Neoplasm, Residual | 4 | BeFree |
| umls:C1840451 | MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 4 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | GAD |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0041671 | Attention Deficit Disorder | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0150055 | Chronic pain | 1 | BeFree |
| umls:C1963674 | Spinocerebellar Ataxia 10 | 1 | BeFree |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
| umls:C3280284 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 10 | 1 | CLINVAR,UNIPROT |
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