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| TissGeneSummary for DLC1 |
 Gene summary |
| Basic gene information | Gene symbol | DLC1 |
| Gene name | DLC1 Rho GTPase activating protein | |
| Synonyms | ARHGAP7|HP|STARD12|p122-RhoGAP | |
| Cytomap | UCSC genome browser: 8p22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001164271.1, NM_006094.4,NM_024767.3,NM_182643.2, | |
| Description | Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2rho GTPase-activating protein 7rho-type GTPase-activating pr | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604258 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164741 | ||
| HPRD : 05035 | ||
| Vega : OTTHUMG00000090825 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DLC1 | |
| BioGPS: 10395 | ||
| Pathway | NCI Pathway Interaction Database: DLC1 | |
| KEGG: DLC1 | ||
| REACTOME: DLC1 | ||
| Pathway Commons: DLC1 | ||
| Context | iHOP: DLC1 | |
| ligand binding site mutation search in PubMed: DLC1 | ||
| UCL Cancer Institute: DLC1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSARC | |
| Reference showing the relevant tissue of DLC1 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006915 | apoptotic process | 17292327 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17888903 | GO:0008285 | negative regulation of cell proliferation | 12545165 | GO:0030336 | negative regulation of cell migration | 17932950 | GO:0032321 | positive regulation of Rho GTPase activity | 17932950 | GO:0035307 | positive regulation of protein dephosphorylation | 17292327 | GO:0051497 | negative regulation of stress fiber assembly | 17932950 | GO:1900119 | positive regulation of execution phase of apoptosis | 17888903 | GO:0006915 | apoptotic process | 17292327 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17888903 | GO:0008285 | negative regulation of cell proliferation | 12545165 | GO:0030336 | negative regulation of cell migration | 17932950 | GO:0032321 | positive regulation of Rho GTPase activity | 17932950 | GO:0035307 | positive regulation of protein dephosphorylation | 17292327 | GO:0051497 | negative regulation of stress fiber assembly | 17932950 | GO:1900119 | positive regulation of execution phase of apoptosis | 17888903 |
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| TissGeneExp for DLC1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 1.390766808 | 2.537450808 | -1.146684 | 2.82E-05 | 8.21E-05 |
| LIHC | 1.506248808 | 2.843738808 | -1.33749 | 2.84E-14 | 7.79E-13 |
| LUAD | 2.199181497 | 4.728764256 | -2.529582759 | 1.28E-24 | 5.04E-23 |
| LUSC | 0.722850023 | 4.710440219 | -3.987590196 | 9.34E-31 | 4.48E-29 |
| BRCA | 1.658864316 | 3.242723966 | -1.583859649 | 1.47E-29 | 1.88E-28 |
| KIRP | 1.131685808 | 2.362110808 | -1.230425 | 1.42E-08 | 1.07E-07 |
| BLCA | 0.510821334 | 2.07843186 | -1.567610526 | 0.000134 | 0.001379704 |
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| TissGene-miRNA for DLC1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-200b-3p | MIMAT0000318 | 0.049 | -0.26 | 60 |
| ACC | hsa-miR-200b-3p | MIMAT0000318 | 0.034 | -0.27 | 78 |
| ACC | hsa-miR-24-3p | MIMAT0000080 | 0.036 | -0.27 | 78 |
| ACC | hsa-miR-200b-3p | MIMAT0000318 | 0.034 | -0.27 | 78 |
| ACC | hsa-miR-24-3p | MIMAT0000080 | 0.036 | -0.27 | 78 |
| ACC | hsa-miR-186-5p | MIMAT0000456 | 0.024 | -0.3 | 78 |
| ACC | hsa-miR-186-5p | MIMAT0000456 | 0.024 | -0.3 | 78 |
| ACC | hsa-let-7g-5p | MIMAT0000414 | 0.01 | -0.32 | 78 |
| ACC | hsa-let-7g-5p | MIMAT0000414 | 0.01 | -0.32 | 78 |
| LUAD | hsa-miR-429 | MIMAT0001536 | 0.0053 | -0.36 | 60 |
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| TissGeneMut for DLC1 |
| TissGeneSNV for DLC1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S741T | BLCA | 4 |
| p.R338C | UCEC | 2 |
| p.S741T | TGCT | 2 |
| p.S620F | SKCM | 2 |
| p.S741T | LGG | 2 |
| p.S741T | PRAD | 2 |
| p.R54C | UCEC | 2 |
| p.G143E | SKCM | 2 |
| p.V791M | COAD | 2 |
| p.V940I | SKCM | 1 |
| p.T420M | THCA | 1 |
| p.D561N | SKCM | 1 |
| p.H66N | BLCA | 1 |
| p.R1425Q | UCEC | 1 |
| p.D89Y | LUAD | 1 |
| p.R1384C | BLCA | 1 |
| p.Q280X | COAD | 1 |
| p.R1100X | COAD | 1 |
| p.G293D | BRCA | 1 |
| p.T1270S | THCA | 1 |
| p.S741T | LIHC | 1 |
| p.V183G | STAD | 1 |
| p.C1442F | COAD | 1 |
| p.D1327E | SKCM | 1 |
| p.E657K | READ | 1 |
| p.Q1097X | COAD | 1 |
| p.H1422Y | BLCA | 1 |
| p.V1215I | ACC | 1 |
| p.D84N | DLBC | 1 |
| p.M1290I | LUSC | 1 |
| p.S830L | HNSC | 1 |
| p.R388Q | STAD | 1 |
| p.A607V | COAD | 1 |
| p.R410L | LUAD | 1 |
| p.S160Y | BLCA | 1 |
| p.G987V | LUAD | 1 |
| p.H848Y | SKCM | 1 |
| p.R347* | UCEC | 1 |
| p.G400E | LGG | 1 |
| p.R595H | COAD | 1 |
| p.C1328G | SKCM | 1 |
| p.V175I | LUSC | 1 |
| p.S741T | UCS | 1 |
| p.R1086C | LAML | 1 |
| p.R410* | GBM | 1 |
| p.S395L | SKCM | 1 |
| p.R730Q | HNSC | 1 |
| p.P152S | UCEC | 1 |
| p.E552Q | STAD | 1 |
| p.S453* | BRCA | 1 |
| p.R410Q | COAD | 1 |
| p.G293S | SKCM | 1 |
| p.A1274G | STAD | 1 |
| p.R410* | LUAD | 1 |
| p.D858N | OV | 1 |
| p.Q441* | SKCM | 1 |
| p.W10L | LUAD | 1 |
| p.C1473S | COAD | 1 |
| p.K339N | ESCA | 1 |
| p.N304T | STAD | 1 |
| p.D89E | LUAD | 1 |
| p.G655C | STAD | 1 |
| p.R918W | PAAD | 1 |
| p.F1333L | UCEC | 1 |
| p.H998R | UCEC | 1 |
| p.D123N | READ | 1 |
| p.S1318L | BLCA | 1 |
| p.P604S | SKCM | 1 |
| p.S1499Y | HNSC | 1 |
| p.S186Y | LGG | 1 |
| p.T760M | ESCA | 1 |
| p.H519N | ESCA | 1 |
| p.Q1413R | GBM | 1 |
| p.P282S | SKCM | 1 |
| p.P947L | SKCM | 1 |
| p.G638D | STAD | 1 |
| p.R1294C | STAD | 1 |
| p.S1349X | ESCA | 1 |
| p.P815S | STAD | 1 |
| p.A232T | PRAD | 1 |
| p.R1155* | UCEC | 1 |
| p.M1T | STAD | 1 |
| p.R410X | READ | 1 |
| p.H109Y | LUAD | 1 |
| p.S414Y | UCEC | 1 |
| p.A401T | UCEC | 1 |
| p.A460T | PRAD | 1 |
| p.M774K | LUSC | 1 |
| p.A718T | BLCA | 1 |
| p.V36A | BLCA | 1 |
| p.K182N | LUSC | 1 |
| p.R866C | LUAD | 1 |
| p.L1018P | THCA | 1 |
| p.L174Q | HNSC | 1 |
| p.L98I | HNSC | 1 |
| p.Q441X | SKCM | 1 |
| p.K1261N | BLCA | 1 |
| p.T213N | UCEC | 1 |
| p.G931R | ESCA | 1 |
| p.A173E | READ | 1 |
| p.V1227M | COAD | 1 |
| p.S688T | BLCA | 1 |
| p.R1453C | UCEC | 1 |
| p.H389L | SKCM | 1 |
| p.S1074N | LUAD | 1 |
| p.P961H | BRCA | 1 |
| p.R670P | LGG | 1 |
| p.Q155K | LUAD | 1 |
| p.S160F | SKCM | 1 |
| p.T1163M | LGG | 1 |
| p.L1386P | STAD | 1 |
| p.E1361K | STAD | 1 |
| p.S741T | LUAD | 1 |
| p.S544R | PCPG | 1 |
| p.G1117E | SKCM | 1 |
| p.D1145H | BLCA | 1 |
| p.R54C | STAD | 1 |
| p.G464S | STAD | 1 |
| p.S1244F | SKCM | 1 |
| p.K455N | LUAD | 1 |
| p.A30S | STAD | 1 |
| p.A990S | UCEC | 1 |
| p.R235Q | CESC | 1 |
| p.E587K | BLCA | 1 |
| p.P435L | KIRC | 1 |
| p.Q328R | DLBC | 1 |
| p.F637L | ESCA | 1 |
| p.R588H | STAD | 1 |
| p.R1182H | UCEC | 1 |
| p.P564S | SKCM | 1 |
| p.S248I | STAD | 1 |
| p.T1163M | COAD | 1 |
| p.D525E | HNSC | 1 |
| p.S764R | STAD | 1 |
| p.E590D | STAD | 1 |
| p.R1384C | READ | 1 |
| p.S289P | LGG | 1 |
| p.S300* | CESC | 1 |
| p.R1384C | PAAD | 1 |
| p.D932N | LUSC | 1 |
| p.G696R | HNSC | 1 |
| p.S741T | SKCM | 1 |
| p.D1148N | LUAD | 1 |
| p.R994M | LUAD | 1 |
| p.C284Y | STAD | 1 |
| p.I202M | SKCM | 1 |
| p.I497M | HNSC | 1 |
| p.V1146L | LIHC | 1 |
| p.P643S | PAAD | 1 |
| p.G143R | SKCM | 1 |
| p.V110A | LIHC | 1 |
| p.K465N | KIRC | 1 |
| p.E447K | SKCM | 1 |
| p.G165R | LUAD | 1 |
| p.L191P | SKCM | 1 |
| p.A232T | LGG | 1 |
| p.S1167L | COAD | 1 |
| p.F458L | ESCA | 1 |
| p.R54C | LAML | 1 |
| p.S650N | UCEC | 1 |
| p.P241H | LUAD | 1 |
| p.A614T | BLCA | 1 |
| p.D1398G | BLCA | 1 |
| p.L40M | LUAD | 1 |
| p.I1190F | STAD | 1 |
| p.T1298A | STAD | 1 |
| p.D185G | COAD | 1 |
| p.W17* | ESCA | 1 |
| p.A229V | KIRC | 1 |
| p.E256K | BLCA | 1 |
| p.P758L | LIHC | 1 |
| p.V1084M | UCEC | 1 |
| p.A718T | COAD | 1 |
| p.H490Y | SKCM | 1 |
| p.S593F | SKCM | 1 |
| p.P74S | SKCM | 1 |
| p.D893E | STAD | 1 |
| p.E905A | STAD | 1 |
| p.Q441E | LUAD | 1 |
| p.V882M | SKCM | 1 |
| p.R1384C | UCEC | 1 |
| p.Q367K | LUSC | 1 |
| p.Q1202H | KIRC | 1 |
| p.S682N | UCEC | 1 |
| p.E706K | HNSC | 1 |
| p.L822F | STAD | 1 |
| p.D1195E | LUAD | 1 |
| p.A102D | BRCA | 1 |
| p.V1118I | GBM | 1 |
| p.W17X | ESCA | 1 |
| p.E1379Q | ESCA | 1 |
| p.C1328F | BRCA | 1 |
| p.T755M | STAD | 1 |
| p.D239N | HNSC | 1 |
| p.S679C | HNSC | 1 |
| p.R27H | MESO | 1 |
| p.T738S | BLCA | 1 |
| p.N855K | HNSC | 1 |
| p.K182N | ESCA | 1 |
| p.K1510T | UCEC | 1 |
| p.P947S | THCA | 1 |
| p.D185V | ESCA | 1 |
| p.N725D | STAD | 1 |
| p.M78V | SKCM | 1 |
| p.R351W | LIHC | 1 |
| p.C1328F | ESCA | 1 |
| p.R1121Q | COAD | 1 |
| p.E715G | STAD | 1 |
| p.P1364L | SKCM | 1 |
| p.L459F | CESC | 1 |
| p.A1278G | STAD | 1 |
| p.S1296Y | CESC | 1 |
| p.E180K | SKCM | 1 |
| p.V511M | ESCA | 1 |
| p.E222K | LUAD | 1 |
| p.L61P | STAD | 1 |
| p.G19V | LUAD | 1 |
| p.E1288K | LUSC | 1 |
| p.D1108E | COAD | 1 |
| p.R798H | COAD | 1 |
| p.Q1184R | CESC | 1 |
| p.D185G | BRCA | 1 |
| p.E1403K | COAD | 1 |
| p.M355I | READ | 1 |
| p.Q158E | UCEC | 1 |
| p.V1058L | KIRC | 1 |
| p.V624I | HNSC | 1 |
| p.K1523E | SKCM | 1 |
| p.P241H | THYM | 1 |
| p.D63N | CESC | 1 |
| p.K1498* | LUAD | 1 |
| p.I516M | STAD | 1 |
| p.T272I | HNSC | 1 |
| p.S1355F | SKCM | 1 |
| p.F1515L | LUAD | 1 |
| p.A1057V | COAD | 1 |
| p.G987A | BRCA | 1 |
| p.H519D | LUSC | 1 |
| p.S828F | SKCM | 1 |
| p.R984S | HNSC | 1 |
| p.R617Q | UCEC | 1 |
| p.E460K | SKCM | 1 |
| p.T420R | KIRP | 1 |
| p.L506V | COAD | 1 |
| p.R1198Q | COAD | 1 |
| p.A686S | COAD | 1 |
| p.R27H | STAD | 1 |
| p.S741T | KIRP | 1 |
| p.M703I | LUAD | 1 |
| p.N1295D | STAD | 1 |
| p.P1364S | SKCM | 1 |
| p.A290S | LUAD | 1 |
| p.R595C | HNSC | 1 |
| p.K675R | PAAD | 1 |
| p.N972D | STAD | 1 |
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| TissGeneCNV for DLC1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DLC1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CB999461 | AHNAK-DLC1 | chr11:62283808 | chr8:12941409 | |
| Chimerdb3.0 | ChiTaRs | NA | T78001 | DLC1-DLC1 | chr8:13356639 | chr8:13251070 | |
| Chimerdb3.0 | ChiTaRs | NA | CR738829 | RPL22-DLC1 | chr1:6245697 | chr8:12940882 | |
| Chimerdb3.0 | ChiTaRs | NA | BF358436 | PPP3CC-DLC1 | chr8:22392911 | chr8:12959711 | |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-D1-A3JQ-01A | ZBTB17-DLC1 | 5'UTR-5'UTR | chr1:16299533 | chr8:12973166 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AN-01A | CHD9-DLC1 | Out-of-frame | Chr16:53308214 | Chr8:13162811 |
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| TissGeneNet for DLC1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| COAD (tumor) | COAD (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| KICH (tumor) | KICH (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| STAD (tumor) | STAD (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| THCA (tumor) | THCA (normal) |
| DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (tumor) | DLC1, SP1, AKT1, SP3, RASA1, S100A10, TNS3, WWC1 (normal) |
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| TissGeneProg for DLC1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DLC1 |
| TissGeneDrug for DLC1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DLC1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 21 | BeFree,GAD,LHGDN |
| umls:C0596263 | Carcinogenesis | 16 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 14 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 14 | BeFree |
| umls:C0678222 | Breast Carcinoma | 12 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 11 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 11 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 7 | BeFree |
| umls:C0023903 | Liver neoplasms | 7 | BeFree,GAD,LHGDN |
| umls:C0699790 | Colon Carcinoma | 7 | BeFree,CLINVAR |
| umls:C1512409 | Hepatocarcinogenesis | 6 | BeFree |
| umls:C0178874 | Tumor Progression | 5 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
| umls:C0600139 | Prostate carcinoma | 5 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 5 | BeFree,LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 4 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 4 | BeFree |
| umls:C0024121 | Lung Neoplasms | 3 | BeFree,LHGDN |
| umls:C0024299 | Lymphoma | 3 | BeFree,LHGDN |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 3 | BeFree,LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
| umls:C0026764 | Multiple Myeloma | 3 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 2 | CTD_human,LHGDN |
| umls:C0153676 | Secondary malignant neoplasm of lung | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0280100 | Solid tumour | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0919267 | ovarian neoplasm | 2 | BeFree,CTD_human |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0023462 | Acute Megakaryocytic Leukemias | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0025286 | Meningioma | 1 | BeFree,LHGDN |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0152021 | Congenital heart disease | 1 | BeFree |
| umls:C0153452 | Malignant neoplasm of gallbladder | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0155826 | Chronic nasopharyngitis | 1 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0278678 | Metastatic Renal Cell Cancer | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0553723 | Squamous cell carcinoma of skin | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1336538 | Supratentorial Primitive Neuroectodermal Tumor | 1 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
| umls:C1762616 | Meningioma, benign, no ICD-O subtype | 1 | BeFree |
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