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| TissGeneSummary for NDC80 |
 Gene summary |
| Basic gene information | Gene symbol | NDC80 |
| Gene name | NDC80 kinetochore complex component | |
| Synonyms | HEC|HEC1|HsHec1|KNTC2|TID3|hsNDC80 | |
| Cytomap | UCSC genome browser: 18p11.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006101.2, | |
| Description | NDC80 homolog, kinetochore complex componentNDC80 kinetochore complex component homologhighly expressed in cancer proteinhighly expressed in cancer, rich in leucine heptad repeatskinetochore associated 2kinetochore protein Hec1kinetochore protein ND | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607272 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000080986 | ||
| HPRD : 06277 | ||
| Vega : OTTHUMG00000131483 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NDC80 | |
| BioGPS: 10403 | ||
| Pathway | NCI Pathway Interaction Database: NDC80 | |
| KEGG: NDC80 | ||
| REACTOME: NDC80 | ||
| Pathway Commons: NDC80 | ||
| Context | iHOP: NDC80 | |
| ligand binding site mutation search in PubMed: NDC80 | ||
| UCL Cancer Institute: NDC80 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderCervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCACESCTGCT | |
| Reference showing the relevant tissue of NDC80 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NDC80 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -2.627916671 | -3.984550569 | 1.356633898 | 2.43E-06 | 8.78E-06 |
| STAD | 0.28726977 | -1.99797398 | 2.28524375 | 1.27E-08 | 5.64E-07 |
| LUAD | -0.491245747 | -3.70317161 | 3.211925862 | 1.07E-25 | 4.90E-24 |
| HNSC | 0.741630235 | -0.748862788 | 1.490493023 | 3.47E-09 | 4.82E-08 |
| BRCA | 0.049372401 | -3.265489002 | 3.314861404 | 3.05E-52 | 3.27E-50 |
| KIRP | -3.01723023 | -4.70836773 | 1.6911375 | 7.10E-06 | 3.06E-05 |
| KIRC | -1.658702452 | -4.138663564 | 2.479961111 | 1.05E-27 | 1.59E-26 |
| LUSC | 0.840930554 | -3.380626309 | 4.221556863 | 6.83E-36 | 1.18E-33 |
| LIHC | -0.92038823 | -4.45684823 | 3.53646 | 7.49E-24 | 1.04E-21 |
| KICH | -3.02215023 | -4.37120223 | 1.349052 | 0.00105 | 0.002273281 |
| ESCA | 0.472124315 | -2.568293867 | 3.040418182 | 2.78E-05 | 0.001388764 |
| BLCA | 0.928522401 | -1.781424967 | 2.709947368 | 5.23E-06 | 0.000116315 |
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| TissGene-miRNA for NDC80 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NDC80 |
| TissGeneSNV for NDC80 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E469Q | BRCA | 1 |
| p.E625Q | CESC | 1 |
| p.P48L | UCEC | 1 |
| p.S139P | LIHC | 1 |
| p.M198I | THYM | 1 |
| p.A491V | THYM | 1 |
| p.R584H | GBM | 1 |
| p.M114I | BLCA | 1 |
| p.P83Q | SKCM | 1 |
| p.D608N | BLCA | 1 |
| p.I518S | UCEC | 1 |
| p.F236C | COAD | 1 |
| p.E533Q | KIRC | 1 |
| p.Q359K | LUSC | 1 |
| p.L619I | UCEC | 1 |
| p.D256N | LUAD | 1 |
| p.L86R | STAD | 1 |
| p.R52G | SKCM | 1 |
| p.L465R | BLCA | 1 |
| p.D512N | LIHC | 1 |
| p.E533K | BLCA | 1 |
| p.E343* | BLCA | 1 |
| p.T591A | UCEC | 1 |
| p.P48L | BLCA | 1 |
| p.I194V | BRCA | 1 |
| p.A605P | COAD | 1 |
| p.E149K | BLCA | 1 |
| p.M588I | LIHC | 1 |
| p.G212E | SKCM | 1 |
| p.E587K | PRAD | 1 |
| p.E234Q | BLCA | 1 |
| p.D608Y | STAD | 1 |
| p.D618A | LUAD | 1 |
| p.E587K | SKCM | 1 |
| p.R576Q | HNSC | 1 |
| p.F102C | STAD | 1 |
| p.R13H | UCEC | 1 |
| p.R153K | BLCA | 1 |
| p.S295L | UCEC | 1 |
| p.M246I | UCEC | 1 |
| p.E522Q | BLCA | 1 |
| p.T571M | KICH | 1 |
| p.A407V | BLCA | 1 |
| p.E200K | CESC | 1 |
| p.Y228C | HNSC | 1 |
| p.R67W | UCEC | 1 |
| p.A184V | COAD | 1 |
| p.H371Y | SKCM | 1 |
| p.E318* | ESCA | 1 |
| p.E642* | ACC | 1 |
| p.L132I | COAD | 1 |
| p.R97* | STAD | 1 |
| p.D190H | CESC | 1 |
| p.E597K | LUAD | 1 |
| p.D124H | BLCA | 1 |
| p.E531Q | CESC | 1 |
| p.E625Q | KIRP | 1 |
| p.E613Q | CESC | 1 |
| p.S62N | LUAD | 1 |
| p.D436H | LUAD | 1 |
| p.R576* | UCEC | 1 |
| p.E318X | ESCA | 1 |
| p.D608H | KIRP | 1 |
| p.K2E | LUAD | 1 |
| p.E388K | BLCA | 1 |
| p.M588I | ACC | 1 |
| p.E409G | THCA | 1 |
| p.R97X | STAD | 1 |
| p.F263V | UCEC | 1 |
| p.L132I | STAD | 1 |
| p.E78Q | CESC | 1 |
| p.E430Q | BLCA | 1 |
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| TissGeneCNV for NDC80 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NDC80 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ776047 | RPL18-NDC80 | chr19:49118684 | chr18:2589255 | |
| Chimerdb3.0 | ChiTaRs | NA | CA311030 | NDC80-NDC80 | chr18:2616634 | chr18:2610751 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-62-A46U-01A | SMCHD1-NDC80 | In-Frame | chr18:2688745 | chr18:2585111 |
| Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-2E-A9G8-01A | SMCHD1-NDC80 | In-Frame | chr18:2656259 | chr18:2601394 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-62-A46U-01A | SMCHD1-NDC80 | In-frame | Chr18:2688745 | Chr18:2585112 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-86-8358-01A | NDC80-TTC39C | Out-of-frame | Chr18:2610860 | Chr18:21703798 |
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| TissGeneNet for NDC80 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NDC80, UBC, PFDN1, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, USHBP1, SPC24, TOM1L1, CENPE, SKA1, NEK2, SPC25, CCDC53 (tumor) | NDC80, SUMO2, AURKA, NUF2, CALCOCO1, SMC1A, RB1, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, USHBP1, SPC24, PSMC2, CENPE, ZW10, SKA1, NEK2, SPC25 (normal) |
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| COAD (tumor) | COAD (normal) |
| NDC80, UBC, AURKA, NUF2, CALCOCO1, RB1, MAD2L1, ZWINT, BUB1, AURKB, CENPB, CENPH, AMOTL2, SPC24, PSMC2, MIS12, CENPE, ZW10, SKA1, NEK2, SPC25 (tumor) | NDC80, HNF4A, UBC, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, USHBP1, SPC24, MIS12, CENPE, ZW10, SKA1, NEK2, SPC25, CCDC53 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NDC80, SUMO2, PFDN1, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, USHBP1, SPC24, PSMC2, CENPE, ZW10, SKA1, NEK2, SPC25 (tumor) | NDC80, UBC, SUMO2, PFDN1, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, SPC24, MIS12, CENPE, SKA1, KLHL12, NEK2, SPC25, CCDC53 (normal) |
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| KICH (tumor) | KICH (normal) |
| NDC80, HNF4A, SUMO2, AURKA, NUF2, SMC1A, RB1, BUB1, AURKB, CENPB, CENPH, AMOTL2, SPC24, TOM1L1, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25, CCDC53 (tumor) | NDC80, UBC, PFDN1, AURKA, NUF2, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, USHBP1, MAD1L1, SPC24, PSMC2, TOM1L1, CENPE, SKA1, NEK2, SPC25, CCDC53 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NDC80, UBC, AURKA, NUF2, CALCOCO1, SMC1A, RB1, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, SPC24, TOM1L1, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25 (tumor) | NDC80, UBC, SUMO2, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, CENPH, MAD1L1, SPC24, PSMC2, MIS12, TOM1L1, CENPE, SKA1, KLHL12, NEK2, SPC25 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NDC80, HNF4A, PFDN1, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, SPC24, TOM1L1, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25 (tumor) | NDC80, HNF4A, UBC, SUMO2, PFDN1, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, AMOTL2, USHBP1, SPC24, CENPE, SKA1, NEK2, SPC25 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NDC80, HNF4A, PFDN1, AURKA, NUF2, RB1, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, USHBP1, SPC24, PSMC2, CENPE, SKA1, KLHL12, NEK2, SPC25, CCDC53 (tumor) | NDC80, SUMO2, PFDN1, AURKA, NUF2, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPB, CENPH, AMOTL2, USHBP1, SPC24, CENPE, ZW10, SKA1, NEK2, SPC25 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NDC80, SUMO2, PFDN1, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, USHBP1, SPC24, PSMC2, MIS12, CENPE, SKA1, NEK2, SPC25, CCDC53 (tumor) | NDC80, SUMO2, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, USHBP1, SPC24, PSMC2, TOM1L1, CENPE, ZW10, SKA1, NEK2, SPC25 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NDC80, HNF4A, UBC, AURKA, NUF2, CALCOCO1, RB1, MAD2L1, ZWINT, BUB1, AURKB, CENPH, MAD1L1, SPC24, PSMC2, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25 (tumor) | NDC80, SUMO2, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, CENPH, USHBP1, SPC24, PSMC2, MIS12, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NDC80, HNF4A, SUMO2, PFDN1, AURKA, NUF2, CALCOCO1, CENPB, CENPH, AMOTL2, USHBP1, SPC24, MIS12, TOM1L1, CENPE, ZW10, SKA1, KLHL12, NEK2, SPC25, CCDC53 (tumor) | NDC80, HNF4A, SUMO2, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, CENPB, CENPH, USHBP1, SPC24, PSMC2, TOM1L1, CENPE, SKA1, KLHL12, NEK2, SPC25 (normal) |
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| STAD (tumor) | STAD (normal) |
| NDC80, HNF4A, PFDN1, AURKA, NUF2, CALCOCO1, MAD2L1, ZWINT, BUB1, AURKB, CENPB, CENPH, USHBP1, MAD1L1, SPC24, PSMC2, TOM1L1, CENPE, SKA1, NEK2, SPC25 (tumor) | NDC80, HNF4A, UBC, AURKA, NUF2, CALCOCO1, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, USHBP1, SPC24, PSMC2, CENPE, ZW10, SKA1, NEK2, SPC25 (normal) |
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| THCA (tumor) | THCA (normal) |
| NDC80, UBC, SUMO2, AURKA, NUF2, CALCOCO1, RB1, MAD2L1, ZWINT, BUB1, AURKB, CENPH, AMOTL2, MAD1L1, SPC24, TOM1L1, CENPE, SKA1, KLHL12, NEK2, SPC25 (tumor) | NDC80, SUMO2, PFDN1, AURKA, NUF2, SMC1A, MAD2L1, ZWINT, BUB1, AURKB, NSL1, CENPH, AMOTL2, MAD1L1, SPC24, PSMC2, TOM1L1, CENPE, SKA1, NEK2, SPC25 (normal) |
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| TissGeneProg for NDC80 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NDC80 |
| TissGeneDrug for NDC80 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NDC80 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0476089 | Endometrial Carcinoma | 38 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 20 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 20 | BeFree |
| umls:C1153706 | Endometrial adenocarcinoma | 19 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0206687 | Carcinoma, Endometrioid | 3 | BeFree |
| umls:C1569637 | Adenocarcinoma, Endometrioid | 3 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0007130 | Mucinous Adenocarcinoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0279672 | Cervical Adenocarcinoma | 1 | BeFree |
| umls:C0346156 | Benign neoplasm of breast | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
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