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TissGeneSummary for WFDC2 |
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Basic gene information | Gene symbol | WFDC2 |
Gene name | WAP four-disulfide core domain 2 | |
Synonyms | EDDM4|HE4|WAP5|dJ461P17.6 | |
Cytomap | UCSC genome browser: 20q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_006103.3, NM_080733.1,NM_080734.1,NM_080735.1,NM_080736.1, | |
Description | WAP domain containing protein HE4-V4WAP four-disulfide core domain protein 2epididymal protein 4epididymal secretory protein E4epididymis-specific, whey-acidic protein type, four-disulfide coremajor epididymis-specific protein E4putative protease in | |
Modification date | 20141222 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000101443 | ||
HPRD : 11684 | ||
Vega : OTTHUMG00000032594 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WFDC2 | |
BioGPS: 10406 | ||
Pathway | NCI Pathway Interaction Database: WFDC2 | |
KEGG: WFDC2 | ||
REACTOME: WFDC2 | ||
Pathway Commons: WFDC2 | ||
Context | iHOP: WFDC2 | |
ligand binding site mutation search in PubMed: WFDC2 | ||
UCL Cancer Institute: WFDC2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixOvaryUterus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCOVUCEC,UCS | |
Reference showing the relevant tissue of WFDC2 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for WFDC2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.494739508 | 3.143682563 | -2.648943056 | 1.08E-15 | 5.69E-15 |
LUAD | 4.092995638 | 2.862805983 | 1.230189655 | 1.89E-05 | 5.33E-05 |
PRAD | 0.80017455 | 2.935818781 | -2.135644231 | 1.89E-10 | 3.85E-09 |
HNSC | -1.710713464 | 0.948523745 | -2.659237209 | 0.00301 | 0.008772668 |
LIHC | -4.433655604 | -2.511933604 | -1.921722 | 0.000751 | 0.002106024 |
LUSC | 1.762475455 | 2.927708789 | -1.165233333 | 0.000603 | 0.001154724 |
COAD | -0.20557545 | 2.026820704 | -2.232396154 | 0.000191 | 0.000648808 |
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TissGene-miRNA for WFDC2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WFDC2 |
TissGeneSNV for WFDC2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.I85V | BRCA | 1 |
p.R95Q | SKCM | 1 |
p.P122L | SKCM | 1 |
p.S101L | SKCM | 1 |
p.D44V | LUAD | 1 |
p.R84G | LUAD | 1 |
p.S51L | CESC | 1 |
p.P104S | SKCM | 1 |
p.P71S | SKCM | 1 |
p.L13I | UCEC | 1 |
p.E26D | HNSC | 1 |
p.G64W | SKCM | 1 |
p.C52Y | KIRP | 1 |
p.L14F | SKCM | 1 |
p.P71L | SKCM | 1 |
p.C103Y | KIRP | 1 |
p.P53S | SKCM | 1 |
p.V6G | SKCM | 1 |
p.S11L | BLCA | 1 |
p.A3T | UCEC | 1 |
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TissGeneCNV for WFDC2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WFDC2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU680617 | NUDT16-WFDC2 | chr3:131107294 | chr20:44110102 | |
Chimerdb3.0 | ChiTaRs | NA | BE816517 | WFDC2-WFDC2 | chr20:44099083 | chr20:44099117 | |
Chimerdb3.0 | ChiTaRs | NA | AA406009 | WFDC2-WFDC2 | chr20:44108665 | chr20:44108651 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-Frame | chr20:44099172 | chr20:43804501 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-Frame | chr20:44099171 | chr20:43804501 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-frame | Chr20:44099172 | Chr20:43804502 |
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TissGeneNet for WFDC2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WFDC2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WFDC2 |
TissGeneDrug for WFDC2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WFDC2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029925 | Ovarian Carcinoma | 14 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 12 | BeFree |
umls:C0919267 | ovarian neoplasm | 5 | BeFree,LHGDN |
umls:C0677886 | Epithelial ovarian cancer | 4 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |