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| TissGeneSummary for WFDC2 |
 Gene summary |
| Basic gene information | Gene symbol | WFDC2 |
| Gene name | WAP four-disulfide core domain 2 | |
| Synonyms | EDDM4|HE4|WAP5|dJ461P17.6 | |
| Cytomap | UCSC genome browser: 20q13.12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006103.3, NM_080733.1,NM_080734.1,NM_080735.1,NM_080736.1, | |
| Description | WAP domain containing protein HE4-V4WAP four-disulfide core domain protein 2epididymal protein 4epididymal secretory protein E4epididymis-specific, whey-acidic protein type, four-disulfide coremajor epididymis-specific protein E4putative protease in | |
| Modification date | 20141222 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000101443 | ||
| HPRD : 11684 | ||
| Vega : OTTHUMG00000032594 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WFDC2 | |
| BioGPS: 10406 | ||
| Pathway | NCI Pathway Interaction Database: WFDC2 | |
| KEGG: WFDC2 | ||
| REACTOME: WFDC2 | ||
| Pathway Commons: WFDC2 | ||
| Context | iHOP: WFDC2 | |
| ligand binding site mutation search in PubMed: WFDC2 | ||
| UCL Cancer Institute: WFDC2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixOvaryUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCOVUCEC,UCS | |
| Reference showing the relevant tissue of WFDC2 | ||
| Description by TissGene annotations | Risk TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for WFDC2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.494739508 | 3.143682563 | -2.648943056 | 1.08E-15 | 5.69E-15 |
| LUAD | 4.092995638 | 2.862805983 | 1.230189655 | 1.89E-05 | 5.33E-05 |
| PRAD | 0.80017455 | 2.935818781 | -2.135644231 | 1.89E-10 | 3.85E-09 |
| HNSC | -1.710713464 | 0.948523745 | -2.659237209 | 0.00301 | 0.008772668 |
| LIHC | -4.433655604 | -2.511933604 | -1.921722 | 0.000751 | 0.002106024 |
| LUSC | 1.762475455 | 2.927708789 | -1.165233333 | 0.000603 | 0.001154724 |
| COAD | -0.20557545 | 2.026820704 | -2.232396154 | 0.000191 | 0.000648808 |
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| TissGene-miRNA for WFDC2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for WFDC2 |
| TissGeneSNV for WFDC2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I85V | BRCA | 1 |
| p.R95Q | SKCM | 1 |
| p.P122L | SKCM | 1 |
| p.S101L | SKCM | 1 |
| p.D44V | LUAD | 1 |
| p.R84G | LUAD | 1 |
| p.S51L | CESC | 1 |
| p.P104S | SKCM | 1 |
| p.P71S | SKCM | 1 |
| p.L13I | UCEC | 1 |
| p.E26D | HNSC | 1 |
| p.G64W | SKCM | 1 |
| p.C52Y | KIRP | 1 |
| p.L14F | SKCM | 1 |
| p.P71L | SKCM | 1 |
| p.C103Y | KIRP | 1 |
| p.P53S | SKCM | 1 |
| p.V6G | SKCM | 1 |
| p.S11L | BLCA | 1 |
| p.A3T | UCEC | 1 |
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| TissGeneCNV for WFDC2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for WFDC2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BU680617 | NUDT16-WFDC2 | chr3:131107294 | chr20:44110102 | |
| Chimerdb3.0 | ChiTaRs | NA | BE816517 | WFDC2-WFDC2 | chr20:44099083 | chr20:44099117 | |
| Chimerdb3.0 | ChiTaRs | NA | AA406009 | WFDC2-WFDC2 | chr20:44108665 | chr20:44108651 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-Frame | chr20:44099172 | chr20:43804501 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-Frame | chr20:44099171 | chr20:43804501 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AQ-A54N-01A | WFDC2-PI3 | In-frame | Chr20:44099172 | Chr20:43804502 |
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| TissGeneNet for WFDC2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| COAD (tumor) | COAD (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| HNSC (tumor) | HNSC (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| KICH (tumor) | KICH (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| KIRC (tumor) | KIRC (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| KIRP (tumor) | KIRP (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| LIHC (tumor) | LIHC (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| LUAD (tumor) | LUAD (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| LUSC (tumor) | LUSC (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| PRAD (tumor) | PRAD (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| STAD (tumor) | STAD (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| THCA (tumor) | THCA (normal) |
| WFDC2, PTN (tumor) | WFDC2, PTN (normal) |
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| TissGeneProg for WFDC2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for WFDC2 |
| TissGeneDrug for WFDC2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for WFDC2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029925 | Ovarian Carcinoma | 14 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 12 | BeFree |
| umls:C0919267 | ovarian neoplasm | 5 | BeFree,LHGDN |
| umls:C0677886 | Epithelial ovarian cancer | 4 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
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