TissGeneSummary for SPON1 |
Gene summary |
Basic gene information | Gene symbol | SPON1 |
Gene name | spondin 1, extracellular matrix protein | |
Synonyms | VSGP/F-spondin|f-spondin | |
Cytomap | UCSC genome browser: 11p15.2 | |
Type of gene | protein-coding | |
RefGenes | NM_006108.3, | |
Description | spondin 1, (f-spondin) extracellular matrix proteinspondin-1vascular smooth muscle cell growth-promoting factor | |
Modification date | 20141207 | |
dbXrefs | MIM : 604989 | |
HGNC : HGNC | ||
Ensembl : ENSG00000262655 | ||
HPRD : 16087 | ||
Vega : OTTHUMG00000181576 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPON1 | |
BioGPS: 10418 | ||
Pathway | NCI Pathway Interaction Database: SPON1 | |
KEGG: SPON1 | ||
REACTOME: SPON1 | ||
Pathway Commons: SPON1 | ||
Context | iHOP: SPON1 | |
ligand binding site mutation search in PubMed: SPON1 | ||
UCL Cancer Institute: SPON1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungOvary | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCOV | |
Reference showing the relevant tissue of SPON1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPON1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 0.809342277 | 2.733453815 | -1.924111538 | 2.00E-05 | 8.54E-05 |
LUSC | 1.134105173 | 2.675628702 | -1.541523529 | 1.47E-09 | 4.94E-09 |
LIHC | -3.635649416 | -1.923569416 | -1.71208 | 9.26E-06 | 3.94E-05 |
BLCA | 0.398266163 | 3.071192479 | -2.672926316 | 1.18E-06 | 3.70E-05 |
PRAD | 0.339682661 | 1.6190442 | -1.279361538 | 1.42E-07 | 1.29E-06 |
KICH | -4.412509416 | 1.373990584 | -5.7865 | 4.84E-16 | 1.25E-14 |
KIRC | 0.510229029 | 1.520694307 | -1.010465278 | 0.0113 | 0.018730251 |
STAD | 1.366443959 | 3.082818959 | -1.716375 | 0.000199 | 0.001385607 |
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TissGene-miRNA for SPON1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPON1 |
TissGeneSNV for SPON1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A233V | STAD | 1 |
p.H220N | LUAD | 1 |
p.M521I | BLCA | 1 |
p.E673D | STAD | 1 |
p.Y223S | UCEC | 1 |
p.V402G | LUSC | 1 |
p.S454T | BRCA | 1 |
p.R721* | UCEC | 1 |
p.E622D | STAD | 1 |
p.S232F | STAD | 1 |
p.R712* | STAD | 1 |
p.S408L | UCEC | 1 |
p.V265E | LUSC | 1 |
p.E432* | UCEC | 1 |
p.H230R | STAD | 1 |
p.V282I | STAD | 1 |
p.R142P | LUAD | 1 |
p.R690Q | UCEC | 1 |
p.M521L | LUAD | 1 |
p.S162I | UCEC | 1 |
p.R776H | UCEC | 1 |
p.W326R | BLCA | 1 |
p.R757C | UCEC | 1 |
p.S176Y | UCEC | 1 |
p.R272* | UCEC | 1 |
p.A734D | LUAD | 1 |
p.A202V | UCEC | 1 |
p.M363T | UCEC | 1 |
p.R678Q | UCEC | 1 |
p.R721Q | UCEC | 1 |
p.R634Q | UCEC | 1 |
p.R311H | STAD | 1 |
p.C516* | LUSC | 1 |
p.R138W | STAD | 1 |
p.G773E | LUAD | 1 |
p.D649H | BLCA | 1 |
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TissGeneCNV for SPON1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPON1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCS | TCGA-N8-A4PP-01A | SPON1-THAP2 | In-Frame | chr11:14063201 | chr12:72067982 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A24H-01A | PCF11-SPON1 | In-frame | Chr11:82868673 | Chr11:14264878 |
TCGAfusionPortal | PRADA | LGG | TCGA-DU-8166-01A | SPON1-SIRT3 | In-frame | Chr11:14063201 | Chr11:233534 |
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TissGeneNet for SPON1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPON1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPON1 |
TissGeneDrug for SPON1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPON1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
umls:C0029408 | Degenerative polyarthritis | 1 | LHGDN |
umls:C0029423 | Cartilaginous exostosis | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0278512 | Metastatic osteosarcoma | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |