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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FST
check button Gene summary
Basic gene informationGene symbolFST
Gene namefollistatin
SynonymsFS
CytomapUCSC genome browser: 5q11.2
Type of geneprotein-coding
RefGenesNM_006350.3,
NM_013409.2,
Descriptionactivin-binding proteinfollistatin isoform FST317
Modification date20141215
dbXrefs MIM : 136470
HGNC : HGNC
Ensembl : ENSG00000134363
HPRD : 00641
Vega : OTTHUMG00000131183
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FST
BioGPS: 10468
PathwayNCI Pathway Interaction Database: FST
KEGG: FST
REACTOME: FST
Pathway Commons: FST
ContextiHOP: FST
ligand binding site mutation search in PubMed: FST
UCL Cancer Institute: FST
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverOvary
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCOV
Reference showing the relevant tissue of FST
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter12702211
GO:0002244hematopoietic progenitor cell differentiation15451575
GO:0032926negative regulation of activin receptor signaling pathway11948405
GO:0051798positive regulation of hair follicle development12514121
GO:0000122negative regulation of transcription from RNA polymerase II promoter12702211
GO:0002244hematopoietic progenitor cell differentiation15451575
GO:0032926negative regulation of activin receptor signaling pathway11948405
GO:0051798positive regulation of hair follicle development12514121


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TissGeneExp for FST

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC3.6421587150.7553861662.8867725491.18E-146.94E-14
HNSC5.2402096042.4924212322.7477883729.77E-156.28E-13
PRAD0.9453640311.971823647-1.0264596159.70E-065.43E-05
THCA-2.119595323-0.738242781-1.3813525421.10E-074.77E-07
KIRP-3.05064294-0.34400544-2.70663757.34E-073.83E-06
KIRC-1.705881481-0.06527037-1.6406111118.03E-082.26E-07
KICH-1.616080815-0.233328815-1.3827520.002590.005189418
COAD-0.8534417380.382631339-1.2360730770.0006370.001914495


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TissGene-miRNA for FST

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UVMhsa-miR-30b-5pMIMAT00004200.018-0.2680


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TissGeneMut for FST
TissGeneSNV for FST

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R115CSKCM2
p.M108ISKCM1
p.A29GOV1
p.S320LSKCM1
p.L18FREAD1
p.Y291HUCEC1
p.W78*SKCM1
p.R194WSTAD1
p.N109DCHOL1
p.V44FBLCA1
p.D280HBLCA1
p.S320LUCEC1
p.D99NSKCM1
p.D69GCOAD1
p.S57ILUAD1
p.E326KSKCM1
p.E53KSKCM1
p.L13VLIHC1
p.V44IHNSC1
p.C42*LUAD1
p.G133RSTAD1
p.E272KSTAD1
p.V117ILGG1
p.L206PUCS1
p.E49*BLCA1
p.T213NPRAD1
p.L34FSTAD1
p.K166NUCEC1
p.S279LUCEC1
p.R149IREAD1
p.E157GBRCA1
p.V283DSTAD1
p.K166NCOAD1
p.Y235HGBM1
p.Q249KESCA1
p.E327*LUAD1
p.C56*LUAD1
p.E67QBLCA1
p.S320LCOAD1
p.P337LLUAD1


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TissGeneCNV for FST

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FST

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAW068788FST-FSTchr5:52778792chr5:52778800
Chimerdb3.0ChiTaRsNABQ356473MORF4L2-FSTchrX:102935504chr5:52781904


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TissGeneNet for FST

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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COAD (tumor)COAD (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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HNSC (tumor)HNSC (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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KICH (tumor)KICH (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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KIRC (tumor)KIRC (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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KIRP (tumor)KIRP (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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LIHC (tumor)LIHC (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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LUAD (tumor)LUAD (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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LUSC (tumor)LUSC (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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PRAD (tumor)PRAD (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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STAD (tumor)STAD (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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THCA (tumor)THCA (normal)
FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (tumor)FST, C8orf33, TK1, FN1, ADAM12, MEST, BMPR2, TXN, BMPR1A, DIP2A, INHA, INHBA, ANG, ADAM8, FSTL1, INHBE, BMP5 (normal)
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TissGeneProg for FST

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FST
TissGeneDrug for FST

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for FST

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0032460Polycystic Ovary Syndrome10BeFree,CTD_human,GAD,LHGDN
umls:C0029928Ovarian Diseases7BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C2239176Liver carcinoma4BeFree,CTD_human
umls:C0014175Endometriosis3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C1140680Malignant neoplasm of ovary3BeFree,GAD
umls:C0001430Adenoma2BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree
umls:C0006625Cachexia2BeFree
umls:C0013537Eclampsia2BeFree
umls:C0018206granulosa cell tumor2BeFree
umls:C0023903Liver neoplasms2BeFree,CTD_human
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0032002Pituitary Diseases2BeFree
umls:C0032987Ectopic Pregnancy2BeFree
umls:C0243026Sepsis2BeFree,LHGDN
umls:C0269102Endometrioma2BeFree
umls:C0699885Carcinoma of bladder2BeFree
umls:C0919267ovarian neoplasm2BeFree
umls:C1458155Mammary Neoplasms2BeFree,CTD_human
umls:C0000768Congenital Abnormality1BeFree
umls:C0000786Spontaneous abortion1CTD_human
umls:C0002965Angina, Unstable1BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0004364Autoimmune Diseases1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0006145Breast Diseases1BeFree
umls:C0007124Noninfiltrating Intraductal Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0009319Colitis1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0013264Muscular Dystrophy, Duchenne1BeFree
umls:C0014170Endometrial Neoplasms1LHGDN
umls:C0017601Glaucoma1BeFree
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0018939Hematological Disease1BeFree
umls:C0020542Pulmonary Hypertension1BeFree
umls:C0022408Arthropathy1BeFree
umls:C0025202melanoma1BeFree,LHGDN
umls:C0025289Meningitis1BeFree
umls:C0025295Meningitis, Pneumococcal1BeFree
umls:C0025297Viral meningitis1BeFree
umls:C0025874Metrorrhagia1LHGDN
umls:C0026769Multiple Sclerosis1BeFree
umls:C0026846Muscular Atrophy1BeFree
umls:C0026850Muscular Dystrophy1LHGDN
umls:C0027627Neoplasm Metastasis1BeFree,LHGDN
umls:C0027819Neuroblastoma1BeFree
umls:C0028754Obesity1BeFree
umls:C0032000Pituitary Adenoma1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0036572Seizures1BeFree
umls:C0036631Seminoma1BeFree
umls:C0038356Stomach Neoplasms1CTD_human
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0153594Malignant neoplasm of testis1BeFree
umls:C0156344Endometriosis of ovary1BeFree
umls:C0162557Liver Failure, Acute1CTD_human
umls:C0178874Tumor Progression1BeFree
umls:C0206650Fibroadenoma1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0341106Eosinophilic esophagitis1BeFree
umls:C0409959Osteoarthritis, Knee1BeFree
umls:C0410528Skeletal dysplasia1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0751967Multiple Sclerosis, Relapsing-Remitting1BeFree
umls:C0917713Becker Muscular Dystrophy1BeFree
umls:C0920646Renal ischaemia1BeFree
umls:C1134719Invasive Ductal Breast Carcinoma1BeFree
umls:C1153706Endometrial adenocarcinoma1BeFree
umls:C1368683Epithelioma1BeFree
umls:C1370419Granulosa cell tumor of the ovary1BeFree
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1720983Channelopathies1BeFree
umls:C3811653Experimental Organism Basal Cell Carcinoma1BeFree
umls:C3839507Diminished ovarian reserve1BeFree
umls:C0406585Lethal tight skin contracture syndrome (disorder)0MGD