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| TissGeneSummary for HOXB13 |
 Gene summary |
| Basic gene information | Gene symbol | HOXB13 |
| Gene name | homeobox B13 | |
| Synonyms | PSGD | |
| Cytomap | UCSC genome browser: 17q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006361.5, | |
| Description | homeobox protein Hox-B13 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 604607 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000159184 | ||
| HPRD : 05210 | ||
| Vega : OTTHUMG00000159900 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HOXB13 | |
| BioGPS: 10481 | ||
| Pathway | NCI Pathway Interaction Database: HOXB13 | |
| KEGG: HOXB13 | ||
| REACTOME: HOXB13 | ||
| Pathway Commons: HOXB13 | ||
| Context | iHOP: HOXB13 | |
| ligand binding site mutation search in PubMed: HOXB13 | ||
| UCL Cancer Institute: HOXB13 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of HOXB13 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HOXB13 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.098191056 | -3.922214741 | 2.824023684 | 7.06E-14 | 3.39E-13 |
| LUSC | -0.186258652 | -4.317562573 | 4.131303922 | 7.02E-11 | 2.70E-10 |
| LUAD | -1.783613621 | -4.214515346 | 2.430901724 | 3.62E-07 | 1.29E-06 |
| ESCA | 1.130991081 | -3.188454374 | 4.319445455 | 0.00157 | 0.019727006 |
| LIHC | -3.372749828 | -4.508035828 | 1.135286 | 0.00159 | 0.004149694 |
| KIRC | -2.455459551 | -3.592449828 | 1.136990278 | 0.00108 | 0.002030436 |
| KIRP | -0.422234203 | -3.187115453 | 2.76488125 | 0.000278 | 0.000868072 |
| PRAD | 9.013905941 | 7.257779018 | 1.756126923 | 0.00022 | 0.000851503 |
| HNSC | -1.555902154 | -3.465899828 | 1.909997674 | 3.79E-05 | 0.000187007 |
| STAD | 2.577234547 | -1.067027953 | 3.6442625 | 1.47E-05 | 0.000158183 |
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| TissGene-miRNA for HOXB13 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.017 | -0.27 | 78 |
| ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.017 | -0.27 | 78 |
| ACC | hsa-miR-20a-5p | MIMAT0000075 | 0.012 | -0.29 | 78 |
| ACC | hsa-miR-20a-5p | MIMAT0000075 | 0.012 | -0.29 | 78 |
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| TissGeneMut for HOXB13 |
| TissGeneSNV for HOXB13 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D52N | SKCM | 1 |
| p.A198V | UCEC | 1 |
| p.Y130S | HNSC | 1 |
| p.E118K | SKCM | 1 |
| p.W178* | BRCA | 1 |
| p.G84A | BLCA | 1 |
| p.P208H | LUAD | 1 |
| p.R247C | UCEC | 1 |
| p.A210S | LUAD | 1 |
| p.D244N | HNSC | 1 |
| p.C183F | KIRC | 1 |
| p.R220C | STAD | 1 |
| p.R247C | STAD | 1 |
| p.I221N | LUAD | 1 |
| p.A76V | STAD | 1 |
| p.W172G | PRAD | 1 |
| p.E234K | SKCM | 1 |
| p.S202F | READ | 1 |
| p.R258C | STAD | 1 |
| p.G84E | SKCM | 1 |
| p.G186E | SKCM | 1 |
| p.P44H | UCEC | 1 |
| p.D145E | LUSC | 1 |
| p.S254N | UCEC | 1 |
| p.V146A | PRAD | 1 |
| p.G86R | STAD | 1 |
| p.P59Q | ESCA | 1 |
| p.L97P | PRAD | 1 |
| p.P59L | KIRP | 1 |
| p.A210T | STAD | 1 |
| p.A12T | READ | 1 |
| p.P65L | SKCM | 1 |
| p.P222S | SKCM | 1 |
| p.A29T | COAD | 1 |
| p.M140V | UCEC | 1 |
| p.S256W | LUAD | 1 |
| p.R214H | GBM | 1 |
| p.E187K | SKCM | 1 |
| p.K218E | PRAD | 1 |
| p.S171Y | LIHC | 1 |
| p.E119Q | BLCA | 1 |
| p.R214C | UCEC | 1 |
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| TissGeneCNV for HOXB13 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HOXB13 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA622384 | HOXB13-ACTG2 | chr17:46805865 | chr2:74120150 | |
| Chimerdb3.0 | FusionScan | UCS | TCGA-N8-A4PQ-01A | MPRIP-HOXB13 | Out-of-Frame | chr17:16981390 | chr17:46804405 |
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| TissGeneNet for HOXB13 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| COAD (tumor) | COAD (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| KICH (tumor) | KICH (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| STAD (tumor) | STAD (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| THCA (tumor) | THCA (normal) |
| HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (tumor) | HOXB13, ELK1, POU2F1, HOXD4, IRF4, MEIS1, ALX4, ZNF490 (normal) |
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| TissGeneProg for HOXB13 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HOXB13 |
| TissGeneDrug for HOXB13 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HOXB13 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 33 | BeFree,UNIPROT |
| umls:C0600139 | Prostate carcinoma | 33 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 10 | BeFree |
| umls:C0678222 | Breast Carcinoma | 10 | BeFree |
| umls:C0596263 | Carcinogenesis | 7 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 7 | CTD_human,GAD,LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 6 | CTD_human,LHGDN |
| umls:C2931456 | Prostate cancer, familial | 6 | BeFree,CTD_human,ORPHANET |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C2986665 | Early-Stage Breast Carcinoma | 3 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0242656 | Disease Progression | 2 | LHGDN |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
| umls:C0014474 | Ependymoma | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree,CTD_human,LHGDN |
| umls:C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0030354 | Papilloma | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0205769 | Myxopapillary ependymoma | 1 | BeFree |
| umls:C0206725 | Subependymal Glioma | 1 | BeFree |
| umls:C0278493 | Breast cancer recurrent | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
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