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| TissGeneSummary for SLC34A2 |
 Gene summary |
| Basic gene information | Gene symbol | SLC34A2 |
| Gene name | solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 | |
| Synonyms | NAPI-3B|NAPI-IIb|NPTIIb | |
| Cytomap | UCSC genome browser: 4p15.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001177998.1, NM_001177999.1,NM_006424.2, | |
| Description | sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2type II sodium-dependent phosphate transporter 3b | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604217 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157765 | ||
| HPRD : 07251 | ||
| Vega : OTTHUMG00000097757 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC34A2 | |
| BioGPS: 10568 | ||
| Pathway | NCI Pathway Interaction Database: SLC34A2 | |
| KEGG: SLC34A2 | ||
| REACTOME: SLC34A2 | ||
| Pathway Commons: SLC34A2 | ||
| Context | iHOP: SLC34A2 | |
| ligand binding site mutation search in PubMed: SLC34A2 | ||
| UCL Cancer Institute: SLC34A2 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCOV | |
| Reference showing the relevant tissue of SLC34A2 | A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene expression in non-small-cell lung cancer. Wijesinghe P, Bepler G, Bollig-Fischer A. J Thorac Oncol. 2015 Feb;10(2):381-6. doi: 10.1097/JTO.0000000000000337 (pmid:25384172) go to article | |
| Description by TissGene annotations | Risk TissGene in RFS Cancer gene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006817 | phosphate ion transport | 10329428 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 | GO:0035435 | phosphate ion transmembrane transport | 10329428 | GO:0035725 | sodium ion transmembrane transport | 10329428 | GO:0006817 | phosphate ion transport | 10329428 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 | GO:0035435 | phosphate ion transmembrane transport | 10329428 | GO:0035725 | sodium ion transmembrane transport | 10329428 |
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| TissGeneExp for SLC34A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -2.663774516 | 0.640479484 | -3.304254 | 1.26E-07 | 8.64E-07 |
| BRCA | 0.841093835 | 3.384691203 | -2.543597368 | 2.19E-08 | 7.00E-08 |
| THCA | 8.329821281 | 3.813482298 | 4.516338983 | 3.93E-16 | 6.35E-15 |
| KICH | -3.907306516 | 2.899417484 | -6.806724 | 9.60E-17 | 3.21E-15 |
| LUSC | 4.135202504 | 9.897465249 | -5.762262745 | 1.53E-17 | 1.30E-16 |
| LUAD | 8.524384519 | 9.899056932 | -1.374672414 | 3.57E-07 | 1.28E-06 |
| ESCA | 2.603080757 | -1.824982879 | 4.428063636 | 8.52E-05 | 0.002870982 |
| HNSC | -2.031683725 | 1.268879066 | -3.300562791 | 0.000106 | 0.000471344 |
| KIRC | 1.517718762 | 3.531447929 | -2.013729167 | 9.82E-05 | 0.000207024 |
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| TissGene-miRNA for SLC34A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC34A2 |
| TissGeneSNV for SLC34A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V530I | STAD | 2 |
| p.G89E | SKCM | 2 |
| p.R617H | STAD | 1 |
| p.G545D | COAD | 1 |
| p.R179W | SKCM | 1 |
| p.R597C | COAD | 1 |
| p.P679L | SKCM | 1 |
| p.G676D | SKCM | 1 |
| p.T310A | UCEC | 1 |
| p.P583L | COAD | 1 |
| p.D221V | STAD | 1 |
| p.A396T | THYM | 1 |
| p.F531L | LUSC | 1 |
| p.F252V | STAD | 1 |
| p.F94L | STAD | 1 |
| p.A487S | COAD | 1 |
| p.P52L | LIHC | 1 |
| p.E648K | SKCM | 1 |
| p.R581H | UCEC | 1 |
| p.P506L | LUAD | 1 |
| p.D68N | SKCM | 1 |
| p.A10T | COAD | 1 |
| p.A363D | PAAD | 1 |
| p.L485V | KIRP | 1 |
| p.V563I | STAD | 1 |
| p.G96E | SKCM | 1 |
| p.I386F | STAD | 1 |
| p.G88E | SKCM | 1 |
| p.T688M | THCA | 1 |
| p.S484L | SKCM | 1 |
| p.D634H | STAD | 1 |
| p.R513H | BRCA | 1 |
| p.V314I | PRAD | 1 |
| p.E676K | SKCM | 1 |
| p.P3L | SKCM | 1 |
| p.P541L | THYM | 1 |
| p.G204R | SKCM | 1 |
| p.F428L | BRCA | 1 |
| p.V544M | SKCM | 1 |
| p.P410L | SKCM | 1 |
| p.V678D | HNSC | 1 |
| p.E685K | SKCM | 1 |
| p.A121T | CESC | 1 |
| p.S161N | LGG | 1 |
| p.T543S | BLCA | 1 |
| p.S483L | SKCM | 1 |
| p.E345K | LUAD | 1 |
| p.V167I | SARC | 1 |
| p.G447D | STAD | 1 |
| p.G257E | SKCM | 1 |
| p.Y503H | HNSC | 1 |
| p.F407L | SKCM | 1 |
| p.A488T | PAAD | 1 |
| p.S371F | SKCM | 1 |
| p.V422F | LUAD | 1 |
| p.L327F | SKCM | 1 |
| p.A454T | HNSC | 1 |
| p.G97E | SKCM | 1 |
| p.V112M | CESC | 1 |
| p.V543M | SKCM | 1 |
| p.I370L | LUAD | 1 |
| p.P506S | SKCM | 1 |
| p.T450S | SKCM | 1 |
| p.E686K | SKCM | 1 |
| p.W336* | SKCM | 1 |
| p.C630X | STAD | 1 |
| p.R553W | LUSC | 1 |
| p.G99V | LUSC | 1 |
| p.S32I | BLCA | 1 |
| p.G204E | SKCM | 1 |
| p.L7M | SKCM | 1 |
| p.G191A | LUAD | 1 |
| p.L326F | SKCM | 1 |
| p.S174L | SKCM | 1 |
| p.C630* | STAD | 1 |
| p.A473T | HNSC | 1 |
| p.F536I | LUSC | 1 |
| p.L108I | UCEC | 1 |
| p.R578C | SKCM | 1 |
| p.W335X | SKCM | 1 |
| p.T687M | THCA | 1 |
| p.P679T | SKCM | 1 |
| p.G559W | LUAD | 1 |
| p.L484V | KIRP | 1 |
| p.V562I | READ | 1 |
| p.G205R | SKCM | 1 |
| p.G150R | HNSC | 1 |
| p.G23D | LIHC | 1 |
| p.V228E | LIHC | 1 |
| p.D68G | BRCA | 1 |
| p.A628V | BRCA | 1 |
| p.E65K | BLCA | 1 |
| p.Y525* | STAD | 1 |
| p.P506R | SKCM | 1 |
| p.V607I | PAAD | 1 |
| p.G388S | SKCM | 1 |
| p.L274F | PAAD | 1 |
| p.D331N | SKCM | 1 |
| p.F537L | CESC | 1 |
| p.P3S | SKCM | 1 |
| p.G551C | CESC | 1 |
| p.P410H | UCS | 1 |
| p.Y525X | STAD | 1 |
| p.G205E | SKCM | 1 |
| p.T402N | LUAD | 1 |
| p.D67N | SKCM | 1 |
| p.G675D | SKCM | 1 |
| p.P410S | SKCM | 1 |
| p.R553Q | CESC | 1 |
| p.V606I | UCEC | 1 |
| p.G146R | SKCM | 1 |
| p.R577C | SKCM | 1 |
| p.E677K | SKCM | 1 |
| p.E648K | COAD | 1 |
| p.D330N | SKCM | 1 |
| p.C622R | THCA | 1 |
| p.Y54F | KIRP | 1 |
| p.R573* | UCEC | 1 |
| p.G257A | OV | 1 |
| p.A348S | UCEC | 1 |
| p.I540M | SKCM | 1 |
| p.S681L | SARC | 1 |
| p.P409S | SKCM | 1 |
| p.S372F | SKCM | 1 |
| p.I198F | UCEC | 1 |
| p.R598C | LGG | 1 |
| p.E645K | COAD | 1 |
| p.R513L | LUAD | 1 |
| p.E645D | READ | 1 |
| p.G216V | HNSC | 1 |
| p.I539M | SKCM | 1 |
| p.L595M | UCEC | 1 |
| p.L156F | KIRP | 1 |
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| TissGeneCNV for SLC34A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC34A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG996029 | SLC34A2-SLC34A2 | chr4:25679122 | chr4:25679893 | |
| Chimerdb3.0 | ChiTaRs | NA | BC142704 | SLC34A2-ZBTB43 | chr4:25679926 | chr9:129600373 | |
| Chimerdb3.0 | ChiTaRs | non small cell lung cancer | EU236946 | SLC34A2-ROS1 | chr4:25665952 | chr6:117609655 | |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-62-A46Y-01A | SLC34A2-ROS1 | Out-of-Frame | chr4:25678323 | chr6:117650608 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-05-4426-01A | SLC34A2-ROS1 | Out-of-Frame | chr4:25678323 | chr6:117650608 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-05-4426-01A | SLC34A2-ROS1 | Out-of-Frame | chr4:25678323 | chr6:117645577 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-7727-01A | SLC34A2-EEA1 | NA | Chr4:25680370 | Chr12:93229203 |
| TCGAfusionPortal | PRADA | THCA | TCGA-FE-A231-01A | SLC34A2-CLDN7 | 3UTR-5UTR | Chr4:25680370 | Chr17:7166264 |
| TCGAfusionPortal | PRADA | THCA | TCGA-IM-A3U3-01A | SLC34A2-CLDN7 | 3UTR-5UTR | Chr4:25680370 | Chr17:7166264 |
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| TissGeneNet for SLC34A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC34A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC34A2 |
| TissGeneDrug for SLC34A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC34A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0155912 | Pulmonary Alveolar Microlithiasis | 6 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C3263719 | Primary acquired melanosis | 6 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree,CTD_human |
| umls:C0333027 | Microlithiasis | 2 | BeFree |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0085681 | Hyperphosphatemia (disorder) | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1864873 | Testicular Microlithiasis | 1 | BeFree,CTD_human |
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