 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SLCO1B1 |
 Gene summary |
| Basic gene information | Gene symbol | SLCO1B1 |
| Gene name | solute carrier organic anion transporter family, member 1B1 | |
| Synonyms | HBLRR|LST-1|LST1|OATP-C|OATP1B1|OATP2|OATPC|SLC21A6 | |
| Cytomap | UCSC genome browser: 12p | |
| Type of gene | protein-coding | |
| RefGenes | NM_006446.4, | |
| Description | OATP-2liver-specific organic anion transporter 1sodium-independent organic anion-transporting polypeptide 2solute carrier family 21 (organic anion transporter), member 6solute carrier family 21 member 6solute carrier organic anion transporter family | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 604843 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134538 | ||
| HPRD : 09214 | ||
| Vega : OTTHUMG00000169047 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLCO1B1 | |
| BioGPS: 10599 | ||
| Pathway | NCI Pathway Interaction Database: SLCO1B1 | |
| KEGG: SLCO1B1 | ||
| REACTOME: SLCO1B1 | ||
| Pathway Commons: SLCO1B1 | ||
| Context | iHOP: SLCO1B1 | |
| ligand binding site mutation search in PubMed: SLCO1B1 | ||
| UCL Cancer Institute: SLCO1B1 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SLCO1B1 | Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis. Sticova E, Lodererova A, van de Steeg E, Frankova S, Kollar M, Lanska V, Kotalova R, Dedic T, Schinkel AH, Jirsa M. Int J Clin Exp Pathol. 2015 May 1;8(5):5252-62. eCollection 2015 (pmid:26191226) go to article | |
| Description by TissGene annotations | Cancer gene Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SLCO1B1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.445293261 | -2.568385418 | 1.123092157 | 2.86E-06 | 6.84E-06 |
| LIHC | 8.421244975 | 10.65941297 | -2.238168 | 4.14E-07 | 2.46E-06 |
| ESCA | -0.588541389 | -2.590505025 | 2.001963636 | 0.00657 | 0.047440519 |
| STAD | -1.33455815 | -2.610623775 | 1.276065625 | 0.000279 | 0.001856423 |
| Top |
| TissGene-miRNA for SLCO1B1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SLCO1B1 |
| TissGeneSNV for SLCO1B1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R181C | SKCM | 4 |
| p.E126K | SKCM | 2 |
| p.G315E | SKCM | 2 |
| p.G394E | SKCM | 2 |
| p.E165K | SKCM | 2 |
| p.G98R | SKCM | 2 |
| p.W254* | HNSC | 1 |
| p.A408S | THYM | 1 |
| p.R623M | PRAD | 1 |
| p.V235L | LUSC | 1 |
| p.Q5* | SKCM | 1 |
| p.V405I | LGG | 1 |
| p.P187T | LUAD | 1 |
| p.W258L | HNSC | 1 |
| p.A45T | STAD | 1 |
| p.P565H | LUAD | 1 |
| p.P447S | SKCM | 1 |
| p.W171C | OV | 1 |
| p.E289K | LUAD | 1 |
| p.G584E | HNSC | 1 |
| p.E653* | LUSC | 1 |
| p.S272Y | UCEC | 1 |
| p.G76E | SKCM | 1 |
| p.F679C | STAD | 1 |
| p.Q369* | BRCA | 1 |
| p.L567F | HNSC | 1 |
| p.A257T | SKCM | 1 |
| p.F83C | LUSC | 1 |
| p.F262C | LUAD | 1 |
| p.R253Q | SKCM | 1 |
| p.C24F | OV | 1 |
| p.F117L | LUAD | 1 |
| p.G159E | SKCM | 1 |
| p.S272C | LUAD | 1 |
| p.E667K | SKCM | 1 |
| p.L456I | LUAD | 1 |
| p.L545F | LUAD | 1 |
| p.F679V | STAD | 1 |
| p.E74K | SKCM | 1 |
| p.R57W | STAD | 1 |
| p.L626F | LUSC | 1 |
| p.L65F | HNSC | 1 |
| p.G227* | LUSC | 1 |
| p.A646V | STAD | 1 |
| p.A519S | SARC | 1 |
| p.L670I | BLCA | 1 |
| p.E185K | SKCM | 1 |
| p.A519S | ESCA | 1 |
| p.S569L | CESC | 1 |
| p.R57W | COAD | 1 |
| p.Y121H | SKCM | 1 |
| p.H451L | OV | 1 |
| p.G238E | DLBC | 1 |
| p.P15A | SKCM | 1 |
| p.R181C | BLCA | 1 |
| p.S622L | READ | 1 |
| p.E667K | BLCA | 1 |
| p.P275Q | LUAD | 1 |
| p.R532K | HNSC | 1 |
| p.R532M | UCEC | 1 |
| p.I144T | LGG | 1 |
| p.S206Y | UCEC | 1 |
| p.I376F | LUAD | 1 |
| p.A153P | LUAD | 1 |
| p.E60D | BLCA | 1 |
| p.T597A | STAD | 1 |
| p.S166P | STAD | 1 |
| p.G161_splice | LUSC | 1 |
| p.R610C | BRCA | 1 |
| p.V680A | LIHC | 1 |
| p.S62F | SKCM | 1 |
| p.S124Y | UCEC | 1 |
| p.L572P | STAD | 1 |
| p.S37R | BLCA | 1 |
| p.I55M | ESCA | 1 |
| p.D241N | LGG | 1 |
| p.G627V | BLCA | 1 |
| p.E467K | SKCM | 1 |
| p.G389* | LUAD | 1 |
| p.P249S | ESCA | 1 |
| p.I147M | LUAD | 1 |
| p.G389V | LUAD | 1 |
| p.G389L | LUAD | 1 |
| p.H115Q | LGG | 1 |
| p.V454L | LUAD | 1 |
| p.E126X | READ | 1 |
| p.G394E | HNSC | 1 |
| p.S205P | SARC | 1 |
| p.L78S | READ | 1 |
| p.G105R | SKCM | 1 |
| p.G475A | HNSC | 1 |
| p.W259* | LUSC | 1 |
| p.F391L | STAD | 1 |
| p.S137L | SKCM | 1 |
| p.V235M | KIRC | 1 |
| p.R580Q | SKCM | 1 |
| p.L347V | LIHC | 1 |
| p.L344W | LGG | 1 |
| p.K533T | STAD | 1 |
| p.I642T | LUAD | 1 |
| p.Y535X | READ | 1 |
| p.K398T | STAD | 1 |
| p.K28N | PAAD | 1 |
| p.N676H | UCEC | 1 |
| p.L392S | LUAD | 1 |
| p.F38L | LUAD | 1 |
| p.P484S | SKCM | 1 |
| p.R253P | LUSC | 1 |
| p.V158A | BRCA | 1 |
| p.Q314K | LUSC | 1 |
| p.T301K | PRAD | 1 |
| p.R633I | UCEC | 1 |
| p.E289X | ESCA | 1 |
| p.T244S | SARC | 1 |
| p.P455T | LUAD | 1 |
| p.S194C | BLCA | 1 |
| p.K160I | OV | 1 |
| p.W171C | LUSC | 1 |
| p.F199V | UCEC | 1 |
| p.S576L | UCEC | 1 |
| p.L586V | HNSC | 1 |
| p.E12Q | BLCA | 1 |
| p.Y395F | ESCA | 1 |
| p.M48I | SKCM | 1 |
| p.S603C | LUAD | 1 |
| p.R122W | LUSC | 1 |
| p.S418P | PAAD | 1 |
| p.L456R | DLBC | 1 |
| p.M340R | UCEC | 1 |
| p.G354D | KIRC | 1 |
| p.W254* | SKCM | 1 |
| p.D303N | SKCM | 1 |
| p.A408D | LUSC | 1 |
| p.A200T | READ | 1 |
| p.Y169C | LUAD | 1 |
| p.R122G | THYM | 1 |
| p.M390I | LUSC | 1 |
| p.I106N | STAD | 1 |
| p.R610C | PRAD | 1 |
| p.K648N | UCEC | 1 |
| p.W254X | SKCM | 1 |
| p.D443A | UCEC | 1 |
| p.G26V | ESCA | 1 |
| p.E471K | READ | 1 |
| p.N476S | BLCA | 1 |
| p.D686A | LUAD | 1 |
| p.S51Y | LIHC | 1 |
| p.A646D | LUAD | 1 |
| p.G488A | DLBC | 1 |
| p.T323A | UCEC | 1 |
| p.P15L | SKCM | 1 |
| p.E202K | SKCM | 1 |
| p.H555Y | COAD | 1 |
| p.I247L | SKCM | 1 |
| Top |
| TissGeneCNV for SLCO1B1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SLCO1B1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI207430 | EIF3A-SLCO1B1 | chr10:120801937 | chr12:21294366 | |
| Chimerdb3.0 | FusionScan | LGG | TCGA-TM-A84I-01A | MARCH9-SLCO1B1 | In-Frame | chr12:58150867 | chr12:21325583 |
| Chimerdb3.0 | FusionScan | ACC | TCGA-OR-A5LE-01A | SLCO1B1-IAPP | CDS-5'UTR | chr12:21377773 | chr12:21526270 |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-TM-A84I-01A | MARCH9-SLCO1B1 | In-Frame | chr12:58150866 | chr12:21325583 |
| Chimerdb3.0 | TopHat-Fusion | BLCA | TCGA-UY-A78L-01A | SLCO1B1-MAPRE1 | Out-of-Frame | chr12:21316609 | chr20:31421667 |
| Top |
| TissGeneNet for SLCO1B1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SLCO1B1, RXRA, NR1I2, HNF1A (tumor) | SLCO1B1, RXRA, NR1I2, HNF1A (normal) |
 |  |
| Top |
| TissGeneProg for SLCO1B1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SLCO1B1 |
| TissGeneDrug for SLCO1B1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01211 | Clarithromycin | Small molecule | Approved |
| Top |
| TissGeneDisease for SLCO1B1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0026848 | Myopathy | 25 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0020433 | Hyperbilirubinemia | 13 | BeFree,GAD,LHGDN |
| umls:C0857007 | Hyperbilirubinemia, Neonatal | 7 | BeFree,GAD |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree,GAD |
| umls:C0020443 | Hypercholesterolemia | 4 | BeFree,GAD |
| umls:C0020473 | Hyperlipidemia | 4 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree,GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 3 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD |
| umls:C0220991 | Rotor Syndrome | 3 | BeFree,CLINVAR,ORPHANET |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree,GAD |
| umls:C0268306 | Unconjugated hyperbilirubinemia | 3 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0008312 | Primary biliary cirrhosis | 2 | BeFree |
| umls:C0008350 | Cholelithiasis | 2 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree,GAD |
| umls:C0017551 | Gilbert Disease (disorder) | 2 | GAD |
| umls:C0020538 | Hypertensive disease | 2 | BeFree,GAD |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 2 | BeFree |
| umls:C0027947 | Neutropenia | 2 | BeFree,GAD |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0030920 | Peptic Ulcer | 2 | BeFree |
| umls:C0041296 | Tuberculosis | 2 | BeFree,GAD |
| umls:C0242339 | Dyslipidemias | 2 | BeFree |
| umls:C0860204 | Cholestatic liver disease | 2 | BeFree |
| umls:C0947622 | Cholecystolithiasis | 2 | BeFree,GAD |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | BeFree,GAD |
| umls:C2939465 | Deficiency of glucose-6-phosphate dehydrogenase | 2 | BeFree,GAD |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0003838 | Arterial Occlusive Diseases | 1 | GAD |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | GAD |
| umls:C0007930 | Chagas Cardiomyopathy | 1 | GWASCAT |
| umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | GAD |
| umls:C0013182 | Drug Allergy | 1 | BeFree |
| umls:C0017178 | Gastrointestinal Diseases | 1 | GAD |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0020435 | Hyperbilirubinemia, Hereditary | 1 | GAD |
| umls:C0022353 | Neonatal Jaundice | 1 | GAD |
| umls:C0022665 | Kidney Neoplasm | 1 | GAD |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | GAD |
| umls:C0040479 | Torsades de Pointes | 1 | BeFree |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0231528 | Myalgia | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0268307 | Conjugated hyperbilirubinemia | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0333291 | Bleeding ulcer | 1 | BeFree |
| umls:C0333980 | Focal Nodular Hyperplasia | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0392525 | Nephrolithiasis | 1 | BeFree |
| umls:C0598608 | Hyperhomocysteinemia | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C0878544 | Cardiomyopathies | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
| umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |
| umls:C1562928 | Progesterone receptor positive tumor | 1 | BeFree |
| umls:C1846502 | Mammographic Density | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree,GAD |
| umls:C3495426 | Homocysteinemia | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |