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| TissGeneSummary for IGF2BP3 |
 Gene summary |
| Basic gene information | Gene symbol | IGF2BP3 |
| Gene name | insulin-like growth factor 2 mRNA binding protein 3 | |
| Synonyms | CT98|IMP-3|IMP3|KOC|KOC1|VICKZ3 | |
| Cytomap | UCSC genome browser: 7p11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006547.2, | |
| Description | IGF-II mRNA-binding protein 3IGF2 mRNA-binding protein 3KH domain containing protein overexpressed in cancerVICKZ family member 3cancer/testis antigen 98insulin-like growth factor 2 mRNA-binding protein 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608259 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136231 | ||
| HPRD : 16306 | ||
| Vega : OTTHUMG00000128445 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IGF2BP3 | |
| BioGPS: 10643 | ||
| Pathway | NCI Pathway Interaction Database: IGF2BP3 | |
| KEGG: IGF2BP3 | ||
| REACTOME: IGF2BP3 | ||
| Pathway Commons: IGF2BP3 | ||
| Context | iHOP: IGF2BP3 | |
| ligand binding site mutation search in PubMed: IGF2BP3 | ||
| UCL Cancer Institute: IGF2BP3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowSkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLSKCMTGCT | |
| Reference showing the relevant tissue of IGF2BP3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IGF2BP3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 1.585870602 | -1.772073148 | 3.35794375 | 1.16E-09 | 9.32E-08 |
| LUSC | 2.832186411 | -1.425223393 | 4.257409804 | 6.51E-21 | 8.78E-20 |
| KICH | -0.851372648 | -2.911380648 | 2.060008 | 2.44E-05 | 7.17E-05 |
| KIRC | -0.900403703 | -2.62348287 | 1.723079167 | 2.34E-08 | 6.84E-08 |
| HNSC | 2.349746329 | -0.656481578 | 3.006227907 | 4.21E-09 | 5.64E-08 |
| LIHC | -0.410244648 | -2.469880648 | 2.059636 | 4.39E-08 | 3.36E-07 |
| LUAD | 1.200351421 | -1.384867544 | 2.585218966 | 4.64E-11 | 2.92E-10 |
| ESCA | 2.085666625 | -2.804851557 | 4.890518182 | 2.81E-05 | 0.001388764 |
| BLCA | 0.620986721 | -2.676834332 | 3.297821053 | 2.56E-05 | 0.000389962 |
| KIRP | -1.164866898 | -3.204291898 | 2.039425 | 9.37E-05 | 0.000322696 |
| COAD | -0.625160648 | -3.026064494 | 2.400903846 | 8.56E-05 | 0.000318962 |
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| TissGene-miRNA for IGF2BP3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-320a | MIMAT0000510 | 0.043 | -0.26 | 60 |
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| TissGeneMut for IGF2BP3 |
| TissGeneSNV for IGF2BP3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.I503T | PCPG | 3 |
| p.I503T | UVM | 2 |
| p.G215V | LUAD | 1 |
| p.T148I | SKCM | 1 |
| p.G212X | STAD | 1 |
| p.R181M | OV | 1 |
| p.G425C | LUAD | 1 |
| p.R86Q | SKCM | 1 |
| p.R348K | BLCA | 1 |
| p.E461D | KIRP | 1 |
| p.R578W | BRCA | 1 |
| p.Q103* | SKCM | 1 |
| p.T319K | LUAD | 1 |
| p.I474M | UCEC | 1 |
| p.R469I | CESC | 1 |
| p.L196M | LIHC | 1 |
| p.Q143R | THYM | 1 |
| p.K36X | LIHC | 1 |
| p.G388R | SKCM | 1 |
| p.L247F | UCEC | 1 |
| p.E69D | KIRC | 1 |
| p.K36* | LIHC | 1 |
| p.R551I | STAD | 1 |
| p.Q103X | SKCM | 1 |
| p.D137N | SKCM | 1 |
| p.T407A | STAD | 1 |
| p.I470L | UCEC | 1 |
| p.P314L | SKCM | 1 |
| p.K508N | SKCM | 1 |
| p.T326N | UCEC | 1 |
| p.E62K | UCEC | 1 |
| p.P395H | LUAD | 1 |
| p.K346T | UCEC | 1 |
| p.K423N | LUAD | 1 |
| p.V107G | SKCM | 1 |
| p.G7R | HNSC | 1 |
| p.E275K | BLCA | 1 |
| p.E145Q | SKCM | 1 |
| p.P366S | SKCM | 1 |
| p.P574H | SKCM | 1 |
| p.G422D | UCEC | 1 |
| p.G175R | BLCA | 1 |
| p.A209V | UCEC | 1 |
| p.E118K | LUAD | 1 |
| p.K300N | COAD | 1 |
| p.G105R | SKCM | 1 |
| p.K280N | READ | 1 |
| p.A237V | THCA | 1 |
| p.S117L | BLCA | 1 |
| p.I503T | SKCM | 1 |
| p.S496C | CESC | 1 |
| p.M358L | LUAD | 1 |
| p.K473T | UCEC | 1 |
| p.L282F | LUAD | 1 |
| p.D137A | SKCM | 1 |
| p.T407S | LUAD | 1 |
| p.P164T | ESCA | 1 |
| p.S30W | LUAD | 1 |
| p.I302N | STAD | 1 |
| p.D17Y | SARC | 1 |
| p.S127A | ESCA | 1 |
| p.I470M | BLCA | 1 |
| p.L569M | LUAD | 1 |
| p.M453L | COAD | 1 |
| p.L318* | HNSC | 1 |
| p.A237V | READ | 1 |
| p.S227C | BLCA | 1 |
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| TissGeneCNV for IGF2BP3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IGF2BP3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | W81478 | POLR2B-IGF2BP3 | chr4:57897082 | chr7:23419096 | |
| Chimerdb3.0 | ChiTaRs | NA | W81438 | IGF2BP3-POLR2B | chr7:23419383 | chr4:57897001 | |
| Chimerdb3.0 | ChiTaRs | NA | BF326256 | IGF2BP3-SSR2 | chr7:23436512 | chr1:155979325 | |
| Chimerdb3.0 | FusionScan | HNSC | TCGA-CV-7446-01A | IGF2BP3-PKNOX2 | CDS-5'UTR | chr7:23508100 | chr11:125104940 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A124-01A | IGF2BP3-ACSM1 | In-frame | Chr7:23390924 | Chr16:20682993 |
| TCGAfusionPortal | PRADA | THCA | TCGA-BJ-A28V-01A | THADA-IGF2BP3 | Out-of-frame | Chr2:43625110 | Chr7:23458443 |
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| TissGeneNet for IGF2BP3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| COAD (tumor) | COAD (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| KICH (tumor) | KICH (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| STAD (tumor) | STAD (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| THCA (tumor) | THCA (normal) |
| IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (tumor) | IGF2BP3, SIRT7, CAND1, ELAVL1, UBC, CNBP, KIAA0101, CUL3, COPS5, MYC, HNRNPA1, MEPCE, KHDRBS2, POLR1E, PUF60 (normal) |
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| TissGeneProg for IGF2BP3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IGF2BP3 |
| TissGeneDrug for IGF2BP3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IGF2BP3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027627 | Neoplasm Metastasis | 8 | BeFree,LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 4 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 4 | BeFree |
| umls:C0029463 | Osteosarcoma | 3 | BeFree,LHGDN |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree,LHGDN |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0024299 | Lymphoma | 2 | BeFree,LHGDN |
| umls:C0025202 | melanoma | 2 | BeFree,LHGDN |
| umls:C0206695 | Carcinoma, Neuroendocrine | 2 | LHGDN |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree,LHGDN |
| umls:C3539878 | Triple Negative Breast Neoplasms | 2 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007095 | Carcinoid Tumor | 1 | LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 1 | LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree,GAD |
| umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0024314 | Lymphoproliferative Disorders | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | GAD |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0032227 | Pleural effusion disorder | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0206687 | Carcinoma, Endometrioid | 1 | LHGDN |
| umls:C0262584 | Carcinoma, Small Cell | 1 | LHGDN |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C0347176 | Carcinoma in situ of fallopian tube | 1 | BeFree |
| umls:C0455806 | Infant length | 1 | GWASCAT |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0741899 | Poorly differentiated carcinoma | 1 | BeFree |
| umls:C0747845 | early pregnancy | 1 | BeFree |
| umls:C0750952 | Biliary Tract Cancer | 1 | BeFree |
| umls:C0751688 | Malignant Squamous Cell Neoplasm | 1 | BeFree |
| umls:C0854988 | Adenocarcinoma of lung, stage IV | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1266050 | Poorly Differentiated Thyroid Carcinoma | 1 | BeFree |
| umls:C1274310 | Primary cutaneous B-cell lymphoma | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1559154 | Rash and Dermatitis Adverse Event Associated with Chemoradiation | 1 | BeFree |
| umls:C2945759 | aggressive cancer | 1 | BeFree |
| umls:C3163918 | Tumor thrombus | 1 | BeFree |
| umls:C3839280 | High grade serous carcinoma | 1 | BeFree |
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