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| TissGeneSummary for CES1 |
 Gene summary |
| Basic gene information | Gene symbol | CES1 |
| Gene name | carboxylesterase 1 | |
| Synonyms | ACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1 | |
| Cytomap | UCSC genome browser: 16q22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001025194.1, NM_001025195.1,NM_001266.4, | |
| Description | acyl coenzyme A:cholesterol acyltransferaseacyl-coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesterase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 114835 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000198848 | ||
| HPRD : 00268 | ||
| Vega : OTTHUMG00000176718 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CES1 | |
| BioGPS: 1066 | ||
| Pathway | NCI Pathway Interaction Database: CES1 | |
| KEGG: CES1 | ||
| REACTOME: CES1 | ||
| Pathway Commons: CES1 | ||
| Context | iHOP: CES1 | |
| ligand binding site mutation search in PubMed: CES1 | ||
| UCL Cancer Institute: CES1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of CES1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0030855 | epithelial cell differentiation | 21492153 | GO:0030855 | epithelial cell differentiation | 21492153 |
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| TissGeneExp for CES1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.795358701 | 0.105758248 | -1.901116949 | 2.10E-06 | 7.68E-06 |
| STAD | -1.545368341 | 1.224422284 | -2.769790625 | 3.50E-06 | 4.77E-05 |
| LUSC | 2.228151634 | 4.678581046 | -2.450429412 | 9.30E-07 | 2.34E-06 |
| KIRC | -2.200859314 | -0.432189869 | -1.768669444 | 7.86E-08 | 2.21E-07 |
| BRCA | -1.019991916 | 3.074824751 | -4.094816667 | 6.75E-39 | 1.90E-37 |
| LUAD | 1.993106874 | 4.785543081 | -2.792436207 | 6.95E-19 | 1.12E-17 |
| PRAD | 1.009232139 | 2.407997524 | -1.398765385 | 1.20E-07 | 1.11E-06 |
| BLCA | 0.605701067 | 3.268748435 | -2.663047368 | 0.00505 | 0.026614218 |
| KIRP | -2.739971466 | -1.022318341 | -1.717653125 | 0.00621 | 0.014309168 |
| LIHC | 7.217473909 | 8.538073909 | -1.3206 | 0.00303 | 0.007395198 |
| COAD | -0.497954399 | 1.440118678 | -1.938073077 | 6.61E-05 | 0.000254526 |
| KICH | -3.199342091 | -0.424262091 | -2.77508 | 4.56E-05 | 0.000127866 |
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| TissGene-miRNA for CES1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CES1 |
| TissGeneSNV for CES1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E161K | SKCM | 4 |
| p.G19V | PCPG | 3 |
| p.G42E | SKCM | 2 |
| p.L231I | UCEC | 2 |
| p.T291M | KIRC | 2 |
| p.R436Q | STAD | 1 |
| p.S215F | UCEC | 1 |
| p.S305P | LIHC | 1 |
| p.D424G | UCEC | 1 |
| p.P70L | SKCM | 1 |
| p.E393K | SKCM | 1 |
| p.D193E | BLCA | 1 |
| p.Q169* | SKCM | 1 |
| p.L335H | BLCA | 1 |
| p.Q317K | PRAD | 1 |
| p.V323L | UCEC | 1 |
| p.K289R | ESCA | 1 |
| p.K36T | STAD | 1 |
| p.G210R | SKCM | 1 |
| p.R200H | STAD | 1 |
| p.G370R | SKCM | 1 |
| p.P345S | COAD | 1 |
| p.L421F | CESC | 1 |
| p.H343R | UCEC | 1 |
| p.I7V | KIRP | 1 |
| p.A56S | HNSC | 1 |
| p.S306P | LIHC | 1 |
| p.R434W | STAD | 1 |
| p.C87Y | KIRC | 1 |
| p.A160S | BRCA | 1 |
| p.R434Q | STAD | 1 |
| p.L117F | LGG | 1 |
| p.G94W | LUAD | 1 |
| p.D307V | STAD | 1 |
| p.A379S | KIRC | 1 |
| p.S185N | SKCM | 1 |
| p.K290R | ESCA | 1 |
| p.P59L | SKCM | 1 |
| p.A222V | STAD | 1 |
| p.R171C | SKCM | 1 |
| p.A148V | BLCA | 1 |
| p.A150V | UCEC | 1 |
| p.P54S | SKCM | 1 |
| p.E106K | SKCM | 1 |
| p.G321S | KIRP | 1 |
| p.T28I | LUAD | 1 |
| p.Y84C | UCEC | 1 |
| p.F418L | STAD | 1 |
| p.R434Q | SARC | 1 |
| p.K392N | PRAD | 1 |
| p.Q202R | LUSC | 1 |
| p.R105X | ESCA | 1 |
| p.R4C | ESCA | 1 |
| p.G52E | SKCM | 1 |
| p.S214F | SKCM | 1 |
| p.H140Y | SKCM | 1 |
| p.C88Y | KIRC | 1 |
| p.W75X | LIHC | 1 |
| p.A80V | HNSC | 1 |
| p.V322L | UCEC | 1 |
| p.A377S | KIRC | 1 |
| p.E220D | BLCA | 1 |
| p.D419E | LUSC | 1 |
| p.E114K | SKCM | 1 |
| p.A9T | LIHC | 1 |
| p.A222V | COAD | 1 |
| p.R436W | STAD | 1 |
| p.T291M | PAAD | 1 |
| p.G404V | PRAD | 1 |
| p.M282I | LUAD | 1 |
| p.R434W | SKCM | 1 |
| p.V425A | UCEC | 1 |
| p.R199S | THCA | 1 |
| p.K36T | LUAD | 1 |
| p.H284Y | SKCM | 1 |
| p.G349R | HNSC | 1 |
| p.E183K | SKCM | 1 |
| p.Q45K | LUAD | 1 |
| p.E369K | HNSC | 1 |
| p.G187R | SKCM | 1 |
| p.D115N | HNSC | 1 |
| p.I139F | KIRC | 1 |
| p.C285Y | COAD | 1 |
| p.I359L | CESC | 1 |
| p.Q316K | PRAD | 1 |
| p.Q194R | UCEC | 1 |
| p.W200L | KIRC | 1 |
| p.G325A | LUAD | 1 |
| p.R104* | ESCA | 1 |
| p.G19V | UVM | 1 |
| p.A148V | STAD | 1 |
| p.S246Y | UCEC | 1 |
| p.L309V | UCEC | 1 |
| p.G174C | UCEC | 1 |
| p.A149V | BRCA | 1 |
| p.A5S | PRAD | 1 |
| p.T291M | PCPG | 1 |
| p.L11F | SKCM | 1 |
| p.R199C | LUAD | 1 |
| p.Q195R | UCEC | 1 |
| p.A223V | STAD | 1 |
| p.R199C | STAD | 1 |
| p.R64M | PRAD | 1 |
| p.A392D | PAAD | 1 |
| p.R186W | GBM | 1 |
| p.A49T | STAD | 1 |
| p.S179I | LUAD | 1 |
| p.G219E | COAD | 1 |
| p.D28V | CESC | 1 |
| p.V27E | CESC | 1 |
| p.F417L | STAD | 1 |
| p.A48T | STAD | 1 |
| p.I168V | COAD | 1 |
| p.T297M | GBM | 1 |
| p.R200L | ESCA | 1 |
| p.R104Q | COAD | 1 |
| p.G154V | STAD | 1 |
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| TissGeneCNV for CES1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CES1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BP241894 | CES1-H2AFY2 | chr16:55846928 | chr10:71851077 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A7HZ-01A | CES1P2-CES1 | 5'UTR-CDS | chr16:55776429 | chr16:55844576 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A8O2-01A | CES1P2-CES1 | 5'UTR-CDS | chr16:55776429 | chr16:55844576 |
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| TissGeneNet for CES1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| COAD (tumor) | COAD (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| KICH (tumor) | KICH (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| STAD (tumor) | STAD (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| THCA (tumor) | THCA (normal) |
| CES1, BMPR2, GUSB (tumor) | CES1, BMPR2, GUSB (normal) |
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| TissGeneProg for CES1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CES1 |
| TissGeneDrug for CES1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CES1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023449 | Acute lymphocytic leukemia | 5 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 5 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 5 | BeFree |
| umls:C0003850 | Arteriosclerosis | 3 | BeFree |
| umls:C0004153 | Atherosclerosis | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0028754 | Obesity | 3 | BeFree,CTD_human |
| umls:C1263846 | Attention deficit hyperactivity disorder | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C0008384 | Cholesterol Ester Storage Disease | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0011991 | Diarrhea | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | CTD_human |
| umls:C0043208 | Wolman Disease | 2 | BeFree |
| umls:C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
| umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | CTD_human |
| umls:C0020538 | Hypertensive disease | 1 | GAD |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
| umls:C0027412 | Opioid-Related Disorders | 1 | CTD_human |
| umls:C0027947 | Neutropenia | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0079745 | Lymphoma, Large-Cell, Follicular | 1 | BeFree |
| umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
| umls:C0270814 | Spastic syndrome | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0549410 | Palmar-plantar erythrodysesthesia syndrome | 1 | BeFree |
| umls:C0852711 | Sickle Cell Dactylitis | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1609538 | Latent Tuberculosis | 1 | GAD |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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