TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CES1
check button Gene summary
Basic gene informationGene symbolCES1
Gene namecarboxylesterase 1
SynonymsACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1
CytomapUCSC genome browser: 16q22.2
Type of geneprotein-coding
RefGenesNM_001025194.1,
NM_001025195.1,NM_001266.4,
Descriptionacyl coenzyme A:cholesterol acyltransferaseacyl-coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesterase
Modification date20141222
dbXrefs MIM : 114835
HGNC : HGNC
Ensembl : ENSG00000198848
HPRD : 00268
Vega : OTTHUMG00000176718
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CES1
BioGPS: 1066
PathwayNCI Pathway Interaction Database: CES1
KEGG: CES1
REACTOME: CES1
Pathway Commons: CES1
ContextiHOP: CES1
ligand binding site mutation search in PubMed: CES1
UCL Cancer Institute: CES1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of CES1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0030855epithelial cell differentiation21492153
GO:0030855epithelial cell differentiation21492153


Top
TissGeneExp for CES1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-1.7953587010.105758248-1.9011169492.10E-067.68E-06
STAD-1.5453683411.224422284-2.7697906253.50E-064.77E-05
LUSC2.2281516344.678581046-2.4504294129.30E-072.34E-06
KIRC-2.200859314-0.432189869-1.7686694447.86E-082.21E-07
BRCA-1.0199919163.074824751-4.0948166676.75E-391.90E-37
LUAD1.9931068744.785543081-2.7924362076.95E-191.12E-17
PRAD1.0092321392.407997524-1.3987653851.20E-071.11E-06
BLCA0.6057010673.268748435-2.6630473680.005050.026614218
KIRP-2.739971466-1.022318341-1.7176531250.006210.014309168
LIHC7.2174739098.538073909-1.32060.003030.007395198
COAD-0.4979543991.440118678-1.9380730776.61E-050.000254526
KICH-3.199342091-0.424262091-2.775084.56E-050.000127866


Top
TissGene-miRNA for CES1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for CES1
TissGeneSNV for CES1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E161KSKCM4
p.G19VPCPG3
p.G42ESKCM2
p.L231IUCEC2
p.T291MKIRC2
p.R436QSTAD1
p.S215FUCEC1
p.S305PLIHC1
p.D424GUCEC1
p.P70LSKCM1
p.E393KSKCM1
p.D193EBLCA1
p.Q169*SKCM1
p.L335HBLCA1
p.Q317KPRAD1
p.V323LUCEC1
p.K289RESCA1
p.K36TSTAD1
p.G210RSKCM1
p.R200HSTAD1
p.G370RSKCM1
p.P345SCOAD1
p.L421FCESC1
p.H343RUCEC1
p.I7VKIRP1
p.A56SHNSC1
p.S306PLIHC1
p.R434WSTAD1
p.C87YKIRC1
p.A160SBRCA1
p.R434QSTAD1
p.L117FLGG1
p.G94WLUAD1
p.D307VSTAD1
p.A379SKIRC1
p.S185NSKCM1
p.K290RESCA1
p.P59LSKCM1
p.A222VSTAD1
p.R171CSKCM1
p.A148VBLCA1
p.A150VUCEC1
p.P54SSKCM1
p.E106KSKCM1
p.G321SKIRP1
p.T28ILUAD1
p.Y84CUCEC1
p.F418LSTAD1
p.R434QSARC1
p.K392NPRAD1
p.Q202RLUSC1
p.R105XESCA1
p.R4CESCA1
p.G52ESKCM1
p.S214FSKCM1
p.H140YSKCM1
p.C88YKIRC1
p.W75XLIHC1
p.A80VHNSC1
p.V322LUCEC1
p.A377SKIRC1
p.E220DBLCA1
p.D419ELUSC1
p.E114KSKCM1
p.A9TLIHC1
p.A222VCOAD1
p.R436WSTAD1
p.T291MPAAD1
p.G404VPRAD1
p.M282ILUAD1
p.R434WSKCM1
p.V425AUCEC1
p.R199STHCA1
p.K36TLUAD1
p.H284YSKCM1
p.G349RHNSC1
p.E183KSKCM1
p.Q45KLUAD1
p.E369KHNSC1
p.G187RSKCM1
p.D115NHNSC1
p.I139FKIRC1
p.C285YCOAD1
p.I359LCESC1
p.Q316KPRAD1
p.Q194RUCEC1
p.W200LKIRC1
p.G325ALUAD1
p.R104*ESCA1
p.G19VUVM1
p.A148VSTAD1
p.S246YUCEC1
p.L309VUCEC1
p.G174CUCEC1
p.A149VBRCA1
p.A5SPRAD1
p.T291MPCPG1
p.L11FSKCM1
p.R199CLUAD1
p.Q195RUCEC1
p.A223VSTAD1
p.R199CSTAD1
p.R64MPRAD1
p.A392DPAAD1
p.R186WGBM1
p.A49TSTAD1
p.S179ILUAD1
p.G219ECOAD1
p.D28VCESC1
p.V27ECESC1
p.F417LSTAD1
p.A48TSTAD1
p.I168VCOAD1
p.T297MGBM1
p.R200LESCA1
p.R104QCOAD1
p.G154VSTAD1


Top
TissGeneCNV for CES1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for CES1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABP241894CES1-H2AFY2chr16:55846928chr10:71851077
Chimerdb3.0FusionScanESCATCGA-LN-A7HZ-01ACES1P2-CES15'UTR-CDSchr16:55776429chr16:55844576
Chimerdb3.0FusionScanESCATCGA-IG-A8O2-01ACES1P2-CES15'UTR-CDSchr16:55776429chr16:55844576


Top
TissGeneNet for CES1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
CES1, BMPR2, GUSB (tumor)CES1, BMPR2, GUSB (normal)
bullet pointbullet point


Top
TissGeneProg for CES1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for CES1
TissGeneDrug for CES1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for CES1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0023449Acute lymphocytic leukemia5BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia5BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma5BeFree
umls:C0003850Arteriosclerosis3BeFree
umls:C0004153Atherosclerosis3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0023418leukemia3BeFree
umls:C0028754Obesity3BeFree,CTD_human
umls:C1263846Attention deficit hyperactivity disorder3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0008384Cholesterol Ester Storage Disease2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0010068Coronary heart disease2BeFree
umls:C0011991Diarrhea2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0024121Lung Neoplasms2CTD_human
umls:C0043208Wolman Disease2BeFree
umls:C0236736Cocaine-Related Disorders2CTD_human
umls:C0004135Ataxia Telangiectasia1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0020443Hypercholesterolemia1CTD_human
umls:C0020538Hypertensive disease1GAD
umls:C0023473Myeloid Leukemia, Chronic1BeFree
umls:C0023530Leukopenia1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0024305Lymphoma, Non-Hodgkin1BeFree
umls:C0025521Inborn Errors of Metabolism1CTD_human
umls:C0027412Opioid-Related Disorders1CTD_human
umls:C0027947Neutropenia1BeFree
umls:C0031117Peripheral Neuropathy1CTD_human
umls:C0041296Tuberculosis1BeFree
umls:C0079745Lymphoma, Large-Cell, Follicular1BeFree
umls:C0162309Adrenoleukodystrophy1BeFree
umls:C0270814Spastic syndrome1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0549410Palmar-plantar erythrodysesthesia syndrome1BeFree
umls:C0852711Sickle Cell Dactylitis1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C0948380Colorectal cancer metastatic1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1609538Latent Tuberculosis1GAD
umls:C2239176Liver carcinoma1BeFree