TissGeneSummary for TBR1 |
Gene summary |
Basic gene information | Gene symbol | TBR1 |
Gene name | T-box, brain, 1 | |
Synonyms | TBR-1|TES-56 | |
Cytomap | UCSC genome browser: 2q24 | |
Type of gene | protein-coding | |
RefGenes | NM_006593.2, | |
Description | T-box brain protein 1T-brain-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604616 | |
HGNC : HGNC | ||
HPRD : 07055 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TBR1 | |
BioGPS: 10716 | ||
Pathway | NCI Pathway Interaction Database: TBR1 | |
KEGG: TBR1 | ||
REACTOME: TBR1 | ||
Pathway Commons: TBR1 | ||
Context | iHOP: TBR1 | |
ligand binding site mutation search in PubMed: TBR1 | ||
UCL Cancer Institute: TBR1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of TBR1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TBR1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TBR1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TBR1 |
TissGeneSNV for TBR1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G422W | LUAD | 1 |
p.G296A | LUAD | 1 |
p.R392W | READ | 1 |
p.D73N | LIHC | 1 |
p.P69T | LUAD | 1 |
p.G155E | SKCM | 1 |
p.S414W | LGG | 1 |
p.R48I | UCEC | 1 |
p.Q62* | HNSC | 1 |
p.P235S | SKCM | 1 |
p.Q178* | LUSC | 1 |
p.D36N | SKCM | 1 |
p.G198E | SKCM | 1 |
p.L199P | ESCA | 1 |
p.G275D | LUAD | 1 |
p.R392W | COAD | 1 |
p.Q62E | HNSC | 1 |
p.S620L | CESC | 1 |
p.G58W | LUAD | 1 |
p.P135H | LUAD | 1 |
p.P38R | LGG | 1 |
p.A604S | LUSC | 1 |
p.P290L | STAD | 1 |
p.G630E | SKCM | 1 |
p.Q178R | BLCA | 1 |
p.P409S | LUAD | 1 |
p.T375M | STAD | 1 |
p.Y675X | COAD | 1 |
p.A259V | UCEC | 1 |
p.Q373H | UCEC | 1 |
p.G230E | SKCM | 1 |
p.N158T | COAD | 1 |
p.P113S | COAD | 1 |
p.N439D | GBM | 1 |
p.T645M | COAD | 1 |
p.G58V | LUAD | 1 |
p.L407Q | LUAD | 1 |
p.D64H | LUAD | 1 |
p.G268* | LUAD | 1 |
p.W271L | UCEC | 1 |
p.V325E | STAD | 1 |
p.Y333C | STAD | 1 |
p.P235L | SKCM | 1 |
p.A133V | COAD | 1 |
p.I257M | COAD | 1 |
p.Q196L | LUAD | 1 |
p.P290T | LUAD | 1 |
p.G268X | ESCA | 1 |
p.D245Y | ACC | 1 |
p.I377M | LUSC | 1 |
p.P85L | HNSC | 1 |
p.H37Y | BLCA | 1 |
p.P290S | LUSC | 1 |
p.H35Y | PAAD | 1 |
p.V206M | COAD | 1 |
p.H289N | STAD | 1 |
p.P150S | SKCM | 1 |
p.P273S | SKCM | 1 |
p.P170L | LUAD | 1 |
p.G296R | LUAD | 1 |
p.S115F | SKCM | 1 |
p.D70Y | SKCM | 1 |
p.E649G | ESCA | 1 |
p.R285W | HNSC | 1 |
p.K389I | LIHC | 1 |
p.P69L | BLCA | 1 |
p.S238T | LUAD | 1 |
p.A669T | LUAD | 1 |
p.N280H | BLCA | 1 |
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TissGeneCNV for TBR1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TBR1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TBR1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TBR1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TBR1 |
TissGeneDrug for TBR1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TBR1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C3714756 | Intellectual Disability | 3 | BeFree |
umls:C0004352 | Autistic Disorder | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | GAD |