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| TissGeneSummary for UGT2B11 |
 Gene summary |
| Basic gene information | Gene symbol | UGT2B11 |
| Gene name | UDP glucuronosyltransferase 2 family, polypeptide B11 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 4q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001073.1, | |
| Description | UDP glycosyltransferase 2 family proteinUDP glycosyltransferase 2 family, polypeptide B11UDP-glucuronosyltransferase 2B11UDPGT 2B11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603064 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000213759 | ||
| HPRD : 04345 | ||
| Vega : OTTHUMG00000129395 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGT2B11 | |
| BioGPS: 10720 | ||
| Pathway | NCI Pathway Interaction Database: UGT2B11 | |
| KEGG: UGT2B11 | ||
| REACTOME: UGT2B11 | ||
| Pathway Commons: UGT2B11 | ||
| Context | iHOP: UGT2B11 | |
| ligand binding site mutation search in PubMed: UGT2B11 | ||
| UCL Cancer Institute: UGT2B11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCALIHC | |
| Reference showing the relevant tissue of UGT2B11 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for UGT2B11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -2.113765583 | 0.904439502 | -3.018205085 | 1.48E-28 | 6.55E-26 |
| BRCA | 1.154303002 | 3.23639423 | -2.082091228 | 0.000222 | 0.000470732 |
| KICH | -2.459849244 | -1.186381244 | -1.273468 | 0.000105 | 0.000272901 |
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| TissGene-miRNA for UGT2B11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for UGT2B11 |
| TissGeneSNV for UGT2B11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P155S | SKCM | 5 |
| p.W517* | SKCM | 4 |
| p.W517X | SKCM | 4 |
| p.F280L | CESC | 2 |
| p.F126Y | HNSC | 1 |
| p.K134N | UCEC | 1 |
| p.P78T | LUAD | 1 |
| p.G472V | STAD | 1 |
| p.R167Q | LUAD | 1 |
| p.W463C | LUAD | 1 |
| p.Q449* | BLCA | 1 |
| p.M137I | CESC | 1 |
| p.R101* | UCEC | 1 |
| p.M443I | LUSC | 1 |
| p.A162V | LUAD | 1 |
| p.A329T | UCEC | 1 |
| p.L164V | COAD | 1 |
| p.D398G | LGG | 1 |
| p.D401Y | LUAD | 1 |
| p.N418K | LUSC | 1 |
| p.V26L | ESCA | 1 |
| p.M208I | SARC | 1 |
| p.R477L | LUAD | 1 |
| p.F149L | GBM | 1 |
| p.E75K | SKCM | 1 |
| p.P78S | SKCM | 1 |
| p.S143* | LUAD | 1 |
| p.L63I | UCS | 1 |
| p.P190S | SKCM | 1 |
| p.V76F | LUAD | 1 |
| p.K252E | KIRC | 1 |
| p.R459* | SKCM | 1 |
| p.V55L | LUAD | 1 |
| p.Q359K | LUAD | 1 |
| p.V467F | PRAD | 1 |
| p.A57P | HNSC | 1 |
| p.E301D | SKCM | 1 |
| p.S308Y | UCEC | 1 |
| p.A502E | LUAD | 1 |
| p.M205I | UCEC | 1 |
| p.S70F | SKCM | 1 |
| p.R96T | OV | 1 |
| p.P191L | SKCM | 1 |
| p.G251E | SKCM | 1 |
| p.T82I | SKCM | 1 |
| p.V197A | LIHC | 1 |
| p.L218I | HNSC | 1 |
| p.A377V | UCEC | 1 |
| p.D221N | SKCM | 1 |
| p.M258L | LUSC | 1 |
| p.N273K | LUAD | 1 |
| p.Y170C | UCEC | 1 |
| p.V391L | LGG | 1 |
| p.R259* | UCEC | 1 |
| p.N302Y | PRAD | 1 |
| p.D228N | SKCM | 1 |
| p.P436L | UCEC | 1 |
| p.P358T | KIRC | 1 |
| p.H450Y | LUAD | 1 |
| p.N360H | LUAD | 1 |
| p.F516L | UCEC | 1 |
| p.E319* | LUAD | 1 |
| p.G24E | SKCM | 1 |
| p.Y193* | LUAD | 1 |
| p.P366S | UCEC | 1 |
| p.P66S | SKCM | 1 |
| p.G379D | UCEC | 1 |
| p.W262* | SKCM | 1 |
| p.R447I | SKCM | 1 |
| p.S490Y | SKCM | 1 |
| p.G526R | SKCM | 1 |
| p.M443I | UCEC | 1 |
| p.K524T | KIRC | 1 |
| p.R101X | READ | 1 |
| p.S311L | HNSC | 1 |
| p.L457M | LUAD | 1 |
| p.V53M | SKCM | 1 |
| p.S70Y | LUAD | 1 |
| p.F511S | BLCA | 1 |
| p.V94F | HNSC | 1 |
| p.W5* | SKCM | 1 |
| p.P436S | SKCM | 1 |
| p.D458N | SKCM | 1 |
| p.V26A | UCEC | 1 |
| p.M39I | SKCM | 1 |
| p.W223L | UCEC | 1 |
| p.R167W | LGG | 1 |
| p.Q297E | LUAD | 1 |
| p.G303S | SKCM | 1 |
| p.L116R | HNSC | 1 |
| p.P66R | LUAD | 1 |
| p.P269S | SKCM | 1 |
| p.W256X | DLBC | 1 |
| p.V148I | COAD | 1 |
| p.S22C | OV | 1 |
| p.M390T | READ | 1 |
| p.E440D | UCEC | 1 |
| p.D65N | CESC | 1 |
| p.E158D | SARC | 1 |
| p.N125H | UCEC | 1 |
| p.I180V | PCPG | 1 |
| p.E294K | CESC | 1 |
| p.V136L | CESC | 1 |
| p.L9I | UCEC | 1 |
| p.E465K | SKCM | 1 |
| p.H481R | DLBC | 1 |
| p.S261Y | LUAD | 1 |
| p.E112Q | LUSC | 1 |
| p.D424Y | LUAD | 1 |
| p.K510N | UCEC | 1 |
| p.K138N | UCEC | 1 |
| p.D345N | SKCM | 1 |
| p.A162V | GBM | 1 |
| p.P78H | LUAD | 1 |
| p.R477Q | BRCA | 1 |
| p.S104N | SKCM | 1 |
| p.M214I | SKCM | 1 |
| p.T245I | SKCM | 1 |
| p.L363V | BLCA | 1 |
| p.E319Q | BLCA | 1 |
| p.V217L | LUSC | 1 |
| p.Q359H | HNSC | 1 |
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| TissGeneCNV for UGT2B11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for UGT2B11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for UGT2B11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| COAD (tumor) | COAD (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| KICH (tumor) | KICH (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| STAD (tumor) | STAD (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| THCA (tumor) | THCA (normal) |
| UGT2B11, HNF4A, ONECUT1, HNF1A (tumor) | UGT2B11, HNF4A, ONECUT1, HNF1A (normal) |
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| TissGeneProg for UGT2B11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for UGT2B11 |
| TissGeneDrug for UGT2B11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UGT2B11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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