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| TissGeneSummary for RFPL2 |
 Gene summary |
| Basic gene information | Gene symbol | RFPL2 |
| Gene name | ret finger protein-like 2 | |
| Synonyms | RNF79 | |
| Cytomap | UCSC genome browser: 22q12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001098527.2, NM_001159545.1,NM_001159546.1,NM_006605.3, | |
| Description | RING finger protein 79 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605969 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128253 | ||
| HPRD : 09338 | ||
| Vega : OTTHUMG00000030374 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RFPL2 | |
| BioGPS: 10739 | ||
| Pathway | NCI Pathway Interaction Database: RFPL2 | |
| KEGG: RFPL2 | ||
| REACTOME: RFPL2 | ||
| Pathway Commons: RFPL2 | ||
| Context | iHOP: RFPL2 | |
| ligand binding site mutation search in PubMed: RFPL2 | ||
| UCL Cancer Institute: RFPL2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of RFPL2 | ||
| Description by TissGene annotations | Protective TissGene in OS TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RFPL2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for RFPL2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RFPL2 |
| TissGeneSNV for RFPL2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S236F | SKCM | 2 |
| p.R373C | LUSC | 1 |
| p.R145G | ESCA | 1 |
| p.A161V | LIHC | 1 |
| p.R235G | ESCA | 1 |
| p.V208I | KICH | 1 |
| p.G16V | SKCM | 1 |
| p.E80Q | HNSC | 1 |
| p.R119Q | SKCM | 1 |
| p.R301C | HNSC | 1 |
| p.L130P | BLCA | 1 |
| p.V30I | LUAD | 1 |
| p.S23F | SKCM | 1 |
| p.G195S | SKCM | 1 |
| p.L70Q | BLCA | 1 |
| p.K75Q | HNSC | 1 |
| p.T181I | SKCM | 1 |
| p.R155Q | STAD | 1 |
| p.L12I | ACC | 1 |
| p.G185V | LUAD | 1 |
| p.R211C | HNSC | 1 |
| p.A131V | COAD | 1 |
| p.R373H | GBM | 1 |
| p.R65W | READ | 1 |
| p.R122S | SKCM | 1 |
| p.C28F | SKCM | 1 |
| p.C168G | SKCM | 1 |
| p.R301H | LIHC | 1 |
| p.L58H | BLCA | 1 |
| p.N193Y | UCEC | 1 |
| p.P252S | COAD | 1 |
| p.L6R | UCEC | 1 |
| p.R63C | LGG | 1 |
| p.C78* | BRCA | 1 |
| p.M54I | SKCM | 1 |
| p.R209L | HNSC | 1 |
| p.S228F | SKCM | 1 |
| p.T278N | LUAD | 1 |
| p.G275V | LUAD | 1 |
| p.K173N | LUSC | 1 |
| p.R301H | GBM | 1 |
| p.H237Y | SARC | 1 |
| p.P21A | COAD | 1 |
| p.C25S | KIRP | 1 |
| p.R155W | STAD | 1 |
| p.S5L | LIHC | 1 |
| p.G284* | LUSC | 1 |
| p.R119Q | ESCA | 1 |
| p.A192S | UCEC | 1 |
| p.M1I | CESC | 1 |
| p.A8E | LUAD | 1 |
| p.R212C | CESC | 1 |
| p.D254H | KIRC | 1 |
| p.S72F | SKCM | 1 |
| p.R119L | HNSC | 1 |
| p.E376G | STAD | 1 |
| p.D221N | SKCM | 1 |
| p.P256L | SKCM | 1 |
| p.S347T | LUSC | 1 |
| p.V120I | LUAD | 1 |
| p.D75N | UCEC | 1 |
| p.R151C | UCEC | 1 |
| p.E233Q | BLCA | 1 |
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| TissGeneCNV for RFPL2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RFPL2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for RFPL2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| RFPL2, HNF4A (tumor) | RFPL2, HNF4A (normal) |
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| TissGeneProg for RFPL2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RFPL2 |
| TissGeneDrug for RFPL2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RFPL2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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