 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CCL27 |
 Gene summary |
| Basic gene information | Gene symbol | CCL27 |
| Gene name | chemokine (C-C motif) ligand 27 | |
| Synonyms | ALP|CTACK|CTAK|ESKINE|ILC|PESKY|SCYA27 | |
| Cytomap | UCSC genome browser: 9p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006664.3, | |
| Description | C-C motif chemokine 27CC chemokine ILCIL-11 R-alpha-locus chemokineIL-11 Ralpha-locus chemokinecutaneous T-cell attracting chemokinecutaneous T-cell-attracting chemokineskinkinesmall inducible cytokine subfamily A (Cys-Cys), member 27small-inducib | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604833 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000213927 | ||
| HPRD : 05321 | ||
| Vega : OTTHUMG00000019834 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCL27 | |
| BioGPS: 10850 | ||
| Pathway | NCI Pathway Interaction Database: CCL27 | |
| KEGG: CCL27 | ||
| REACTOME: CCL27 | ||
| Pathway Commons: CCL27 | ||
| Context | iHOP: CCL27 | |
| ligand binding site mutation search in PubMed: CCL27 | ||
| UCL Cancer Institute: CCL27 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of CCL27 | Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: potential role of skin-specific chemokine CCL27. van den Broek LJ, Kroeze KL, Waaijman T, Breetveld M, Sampat-Sardjoepersad SC, Niessen FB, Middelkoop E, Scheper RJ, Gibbs S. Tissue Eng Part A. 2014 Jan;20(1-2):197-209. doi: 10.1089/ten.TEA.2013.0123. Epub 2013 Oct 2. (pmid:23980822) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for CCL27 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for CCL27 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for CCL27 |
| TissGeneSNV for CCL27 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L100P | SKCM | 1 |
| p.X113R | KICH | 1 |
| p.S30I | LGG | 1 |
| p.P41L | KIRP | 1 |
| p.N104I | BLCA | 1 |
| p.F25L | KIRC | 1 |
| p.R39Q | READ | 1 |
| p.L46I | PAAD | 1 |
| p.V68M | COAD | 1 |
| p.A32V | STAD | 1 |
| p.D44Y | SKCM | 1 |
| Top |
| TissGeneCNV for CCL27 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CCL27 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for CCL27 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| CCL27, CCBP2 (tumor) | CCL27, CCBP2 (normal) |
 |  |
| Top |
| TissGeneProg for CCL27 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CCL27 |
| TissGeneDrug for CCL27 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for CCL27 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020630 | Hypophosphatasia | 7 | BeFree |
| umls:C0037274 | Dermatologic disorders | 5 | BeFree,LHGDN |
| umls:C0033860 | Psoriasis | 4 | BeFree,LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 3 | BeFree,LHGDN |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0002873 | Anemia of chronic disease | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0011603 | Dermatitis | 2 | BeFree |
| umls:C0013595 | Eczema | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0023827 | liposarcoma | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0026948 | Mycosis Fungoides | 2 | BeFree,LHGDN |
| umls:C0028259 | Nodule | 2 | BeFree |
| umls:C0029463 | Osteosarcoma | 2 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C1275685 | Avellino corneal dystrophy | 2 | BeFree |
| umls:C1290884 | Inflammatory disorder | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
| umls:C0008497 | Choriocarcinoma | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
| umls:C0013336 | Dwarfism | 1 | BeFree |
| umls:C0014518 | Toxic Epidermal Necrolysis | 1 | BeFree |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0024314 | Lymphoproliferative Disorders | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0027709 | Nephrocalcinosis | 1 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
| umls:C0038325 | Stevens-Johnson Syndrome | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | BeFree |
| umls:C0162823 | Dermatitis, Irritant | 1 | BeFree |
| umls:C0205823 | Pleomorphic Lipoma | 1 | BeFree |
| umls:C0205851 | Germ cell tumor | 1 | BeFree |
| umls:C0206692 | Carcinoma, Lobular | 1 | BeFree |
| umls:C0238288 | Muscular Dystrophy, Facioscapulohumeral | 1 | BeFree |
| umls:C0268412 | Infantile hypophosphatasia | 1 | BeFree |
| umls:C0279563 | Lobular carcinoma in situ of breast | 1 | BeFree |
| umls:C0334381 | Non-infiltrating lobular carcinoma | 1 | BeFree |
| umls:C0342637 | Hypocalciuric hypercalcemia, familial, type 1 | 1 | BeFree |
| umls:C0585186 | Cutaneous hypersensitivity | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1840392 | HYPERPIGMENTATION, FAMILIAL PROGRESSIVE | 1 | BeFree |
| umls:C2919327 | Pleomorphic lobular carcinoma in situ | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |